Trigonella foenum graecum seed extract protects kidney function and morphology in diabetic rats via its antioxidant activity

Xue, Wanli; Lei, Jing; Li, Xuanshe; Zhang, Ruijuan

doi:10.1016/j.nutres.2011.05.010

Cited by 76 publications

(43 citation statements)

References 39 publications

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“…In this study, db/db mice appeared to exhibit symptoms such as polydipsia, polyuria, hyperglycemia and obesity, especially in mice they exhibited increased albuminuria and mesangial matrix expansion, suggesting that db/db mice could be used as a model of progressive DN as previously reported. 32,33 Albuminuria, an indicator that implies to the impaired glomerular filtration barrier, is a dominant biochemical feature of developing DN. Progressive expansion of the mesangial matrix is a key histological appearance of DN.…”

Section: Discussionmentioning

confidence: 99%

Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy

Wang

Chen

et al. 2016

Laboratory Investigation

104

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Endoplasmic reticulum (ER) stress, resulting from the accumulation of misfolded and/or unfolded proteins in ER membranes, is involved in the pathogenesis of diabetic nephropathy (DN). The aim of this study was to investigate the role of ER stress inhibitors ursodeoxycholic acid (UDCA) and 4-phenylbutyrate (4-PBA) in the treatment of DN in db/db mice. Findings have revealed that diabetic db/db mice were more hyperglycemic than their non-diabetic controls, and exhibited a marked increase in body weight, water intake, urine volume, fasting plasma glucose, systolic blood pressure, glucose and insulin tolerance. UDCA (40 mg/kg/day) or 4-PBA (100 mg/kg/day) treatment for 12 weeks resulted in an improvement in these biochemical and physical parameters. Moreover, UDCA or 4-PBA intervention markedly decreased urinary albuminuria and attenuated mesangial expansion in diabetic db/db mice, compared with db/db mice treated with vehicle. These beneficial effects of UDCA or 4-PBA on DN were associated with the inhibition of ER stress, as evidenced by the decreased expression of BiP, phospho-IRE1α, phospho-eIF2α, CHOP, ATF-6 and spliced X-box binding protein-1 in vitro and in vivo. UDCA or 4-PBA prevented hyperglycemia-induced or high glucose (HG)-induced apoptosis in podocytes in vivo and in vitro via the inhibition of caspase-3 and caspase-12 activation. Autophagy deficiency was also seen in glomeruli in diabetic mice and HG-incubated podocytes, exhibiting decreased expression of LC3B and Beclin-1, which could be restored by UDCA or 4-PBA treatment. Taken together, our results have revealed an important role of ER stress in the development of DN, and UDCA or 4-PBA treatment may be a potential novel therapeutic approach for the treatment of DN.

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Section: Discussionmentioning

confidence: 99%

Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy

Wang

Chen

et al. 2016

Laboratory Investigation

104

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“…Decrease in the level of IL-6 and inflammation could be correlated to the improvement of the antioxidant enzymes. Furthermore, it also protects kidney from functional and histopathologic abnormalities of DM [137,140]. Studies have also demonstrated the role of fenugreek seeds in improving glucose homeostasis and renal function in alloxan induced diabetic rats by delaying carbohydrate digestion and absorption thereby improving kidney's antioxidant status [138].…”

Section: Trigonella Foenum-graecummentioning

confidence: 99%

“…Its seeds, which mature into long pods, are used as a time-honored remedy for the treatment of diabetes [136]. Several studies has shown it's hypoglycemic, hypocholesterolemic and hyperinsulinemic effects both in patients with IDDM and NIDDM as well as in experimental diabetic animals [137]. Treatment of diabetic rats with fenugreek seed powder for 12 weeks has found to elevate the activity of CAT and SOD as well as the concentration of GSH thereby reversing oxidative damage.…”

Section: Trigonella Foenum-graecummentioning

confidence: 99%

Therapeutic Insights against Oxidative Stress Induced Diabetic Nephropathy: A Review

Sadhukhan¹

2015

J Autoimmune Disord

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“…A huge number of studies have returned positive findings, indicating the efficacy of fenugreek seed as a functional food that can be beneficial in health and disease. Fenugreek is well known for its multiple pharmacological properties including antidiabetic, antioxidative, hypocholesterolemic, antineoplastic, antiinflammatory, antiulcerogenic, antipyretic, immunomodulatory and antitumor (Dixit et al, 2010;Satheeshkumar et al, 2010;Xue et al, 2011). Different active components of fenugreek seeds have been identified and isolated such as polyphenolic flavonoids which exhibit most common properties, that is, hypoglycemic, hypocholesterolemic, hypotriglyceridemic and antiperoxidative (Gupta & Nair, 1999), steroid saponins exhibiting anti-inflammatory and uterus and lactation-stimulating properties (Petit et al, 1995), polysaccharides such as galactomannans contains antidiabetic effects (Madar & Shomer, 1990) and an amino acid 4-hydroxyisoleucine has been shown to possess insulin-mimetic properties (Broca et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological effects ofTrigonella foenum-graecumL. in health and disease

Yadav

Baquer

2013

Pharmaceutical Biology

224

117

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Context: The health benefits and medicinal properties of herbal food products are known since antiquity. Fenugreek [Trigonella foenum-graecum Linn. (Fabaceae)], a seed spice used to enhance flavor, color and texture of food, is employed for medicinal purposes in many traditional systems. A number of epidemiological studies and laboratory research have unraveled the biological actions of fenugreek. Objective: Research on fenugreek in recent years has identified a number of health benefits and physiological attributes in both experimental animals as well as clinical trials in humans. In this study we have reviewed the available scientific literature on fenugreek. Methods: This review article summarizes and reviews published experimental studies and scientific literature from the databases including PubMed, Google and local library searches. Results: The information available in the literature on the health benefits and pharmaceutical effects of Trigonella accounts for its known medicinal properties and adds new therapeutic effects in newer indications. Besides its known medicinal properties such as carminative, gastric stimulant, antidiabetic and galactogogue (lactation-inducer) effects, newer research has identified hypocholesterolemic, antilipidemia, antioxidant, hepatoprotective, anti-inflammatory, antibacterial, antifungal, antiulcer, antilithigenic, anticarcinogenic and other miscellaneous medicinal effects of fenugreek. Although most of these studies have used whole seed powder or different forms of extracts, some have identified active constituents from seeds and attributed them medicinal values for different indications. Conclusion: The resarch on Trigonella exhibits its health benefits and potential medicinal properties in various indications and has little or no side effects, suggesting its pharmaceutical, therapeutic and nutritional potential.

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Trigonella foenum graecum seed extract protects kidney function and morphology in diabetic rats via its antioxidant activity

Cited by 76 publications

References 39 publications

Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy

Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy

Therapeutic Insights against Oxidative Stress Induced Diabetic Nephropathy: A Review

Pharmacological effects ofTrigonella foenum-graecumL. in health and disease

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