Trimetallic Nanoparticles: Greener Synthesis and Their Applications

Nasrollahzadeh, Mahmoud; Sajjadi, Mohaddeseh; Iravani, Siavash; Varma, Rajender S.

doi:10.3390/nano10091784

Cited by 77 publications

(47 citation statements)

References 140 publications

(188 reference statements)

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“…Monometallic, bimetallic and multi-metallic nanoparticles are often synthesized through chemical or physical methods [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. However, there are many benefits to using green approaches, such as flexibility, environmental friendliness, cost-effectiveness and protection [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. Three key factors to be carefully taken care of in the green synthesis method are the choice of green sources for solvent, reducing agent and stabilizing/capping agent [ 38 , 39 , 40 , 41 , 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Bio-Fabrication of Ag-Cu-Co Trimetallic Nanoparticles and Its Fungicidal Activity against Candida auris

Kamli

Srivastava

Hajrah

et al. 2021

JoF

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Candida auris is an emergent multidrug-resistant pathogen that can lead to severe bloodstream infections associated with high mortality rates, especially in hospitalized individuals suffering from serious medical problems. As Candida auris is often multidrug-resistant, there is a persistent demand for new antimycotic drugs with novel antifungal action mechanisms. Here, we reported the facile, one-pot, one-step biosynthesis of biologically active Ag-Cu-Co trimetallic nanoparticles using the aqueous extract of Salvia officinalis rich in polyphenols and flavonoids. These medicinally important phytochemicals act as a reducing agent and stabilize/capping in the nanoparticles’ fabrication process. Fourier Transform-Infrared, Scanning electron microscopy, Transmission Electron Microscopy, Energy dispersive X-Ray, X-ray powder diffraction and Thermogravimetric analysis (TGA) measurements were used to classify the as-synthesized nanoparticles. Moreover, we evaluated the antifungal mechanism of as-synthesized nanoparticles against different clinical isolates of C. auris. The minimum inhibitory concentrations and minimum fungicidal concentrations ranged from 0.39–0.78 μg/mL and 0.78–1.56 μg/mL. Cell count and viability assay further validated the fungicidal potential of Ag-Cu-Co trimetallic nanoparticles. The comprehensive analysis showed that these trimetallic nanoparticles could induce apoptosis and G2/M phase cell cycle arrest in C. auris. Furthermore, Ag-Cu-Co trimetallic nanoparticles exhibit enhanced antimicrobial properties compared to their monometallic counterparts attributed to the synergistic effect of Ag, Cu and Co present in the as-synthesized nanoparticles. Therefore, the present study suggests that the Ag-Cu-Co trimetallic nanoparticles hold the capacity to be a lead for antifungal drug development against C. auris infections.

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Section: Introductionmentioning

confidence: 99%

Facile Bio-Fabrication of Ag-Cu-Co Trimetallic Nanoparticles and Its Fungicidal Activity against Candida auris

Kamli

Srivastava

Hajrah

et al. 2021

JoF

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“…The nanowhiskers with unique shape, electrical, optical, magnetic, and surface properties have shown attractive clinical and biomedical potentials 1 , 2 . Typically, the production of different nanostructures with well-organized morphologies and sizes is highly demanded by researchers and scientists due to their unique applications and properties 3 – 7 .…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of spinel nickel ferrite nanowhiskers and their biomedical applications

Alijani

Iravani

Pourseyedi

et al. 2021

Sci Rep

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Greener methods for the synthesis of various nanostructures with well-organized characteristics and biomedical applicability have demonstrated several advantages, including simplicity, low toxicity, cost-effectiveness, and eco-friendliness. Spinel nickel ferrite (NiFe2O4) nanowhiskers with rod-like structures were synthesized using a simple and green method; these nanostructures were evaluated by X-ray diffraction analysis, transmission electron microscopy, scanning electron microscopy, and X-ray energy diffraction spectroscopy. Additionally, the prepared nanowhiskers could significantly reduce the survival of Leishmania major promastigotes, at a concentration of 500 μg/mL; the survival of promastigotes was reduced to ≃ 26%. According to the results obtained from MTT test (in vitro), it can be proposed that further studies should be conducted to evaluate anti-leishmaniasis activity of these types of nanowhiskers in animal models.

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“…Nanomaterials were widely applied in a multitude of industries due to their advantages in special physiochemical properties, quantum size effect, and specific surface activity (Maynard et al, 2006;Gan and Li, 2012;Goldberg, 2019;He et al, 2019;Nasrollahzadeh et al, 2021). The global consumption of nanoparticles is predicted to be ∼900 tons per year by 2030 (Olteanu et al, 2017;Yaqoob et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Effect of Ag Nanoparticles on Denitrification and Microbial Community in a Paddy Soil

et al. 2021

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The extensive application of Ag nanoparticles (AgNPs) in industry, agriculture, and food processing areas increases the possibility of its release and accumulation to agroecosystem, but the effects of AgNPs to denitrification and the microbial community in paddy ecosystems are still poorly studied. In this study, microcosmic simulation experiments were established to investigate the response of soil denitrification to different levels of AgNPs (i.e., 0.1, 1, 10, and 50 mg/kg) in a paddy soil. Real-time quantitative PCR and high-throughput sequencing were conducted to reveal the microbial mechanism of the nanometer effect. The results showed that, though 0.1–10 mg/kg AgNPs had no significant effects on denitrification rate and N2O emission rate compared to CK and bulk Ag treatments, 50 mg/kg AgNPs significantly stimulated more than 60% increase of denitrification rate and N2O emission rate on the 3rd day (P < 0.05). Real-time quantitative PCR revealed that 50 mg/kg AgNPs significantly decreased the abundance of 16S bacterial rRNA gene, nirS/nirK, cnorB, and nosZ genes, but it did not change the narG gene abundance. The correlation analysis further revealed that the cumulative N2O emission was positively correlated with the ratio of all the five tested denitrifying genes to bacterial 16S rRNA gene (P < 0.05), indicating that the tolerance of narG gene to AgNPs was the key factor of the increase in denitrification in the studied soil. High-throughput sequencing showed that only the 50-mg/kg-AgNP treatment significantly changed the microbial community composition compared to bulk Ag and CK treatments. The response of microbial phylotypes to AgNPs suggested that the most critical bacteria which drove the stimulation of 50 mg/kg AgNPs on N2O emission were Firmicutes and β-proteobacteria, such as Clotridiales, Burkholderiales, and Anaerolineales. This study revealed the effects of AgNPs to denitrification in a paddy ecosystem and could provide a scientific basis for understanding of the environmental and toxicological effects of Ag nanomaterials.

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Trimetallic Nanoparticles: Greener Synthesis and Their Applications

Cited by 77 publications

References 140 publications

Facile Bio-Fabrication of Ag-Cu-Co Trimetallic Nanoparticles and Its Fungicidal Activity against Candida auris

Facile Bio-Fabrication of Ag-Cu-Co Trimetallic Nanoparticles and Its Fungicidal Activity against Candida auris

Biosynthesis of spinel nickel ferrite nanowhiskers and their biomedical applications

Effect of Ag Nanoparticles on Denitrification and Microbial Community in a Paddy Soil

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