Trimethoprim/sulfamethoxazole induced multiorgan dysfunction

Abstract

A 22-year-old African-American man with AIDS who had recently started on trimethoprim/sulfamethoxazole daily for pneumocystis jirovecii pneumonia prophylaxis presented with an altered mental state, malaise and nausea was found to have hepatitis, pancreatitis, rhabdomyolitis, acute kidney injury and haemolytic anaemia. Cessation of Bactrim and supportive care with volume expansion resolved his clinical symptoms and laboratory abnormalities.

Effect of co-administered lopinavir/ritonavir and sulfamethoxazole/trimethoprim on cardiac function and architecture of albino rats

“…Changes in hematological parameters observed in rats treated with SMX/TMP are in agreement with some observations. 15,16 Mallolas et al, 17 in their study reported some cases of LPV/r associated impairments in hematological function which disagrees with observations in this study. 18 Concurrent use of these agents may not have any deleterious effects on hematologic parameters as observed in this study.…”