Trimethoxy Trityl Groups as a Potent Substituent for Anti-cancer Cytidine Analog Prodrugs

The Role of Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitors in The Attenuation of CCl4-Induced Liver Fibrosis in Rats

“…The enhanced fibrolytic effect of the derivatives could be explained due to their structure–activity relationship (SAR) as a literature survey indicated that the inclusion of alkoxy substituents (methoxy, aryloxy and/or methylenedioxy moieties) within the structure could significantly enhance a variety of biological activities due to the expected intensification of the compounds’ lipophilicity [ 96 , 97 , 98 , 99 ]. In particular, the impact of the number and position of methoxy substituents on the extent of several bioactivities including the antioxidant and antiproliferative efficiencies was recently reported [ 100 , 101 ].…”

Dual delivery of carbon monoxide and doxorubicin using haemoglobin–albumin cluster: proof of concept for well-tolerated cancer therapy

“…Spheroids were prepared using a liquid overlay method, as previously described. 23 Colon-26 cells and MCF-7 cells were seeded in an ultra-low attachment 96-well plate (2.5 × 10 3 cells per well), and the plate was spun for 10 min at 500 rpm. After incubation at 37 °C for 3 days, the spheroids were further co-incubated with DOX or CO-HemoAct-DOX (final concentration; DOX: 0.001–1 μM for colon-26 cells and DOX: 0.01–10 μM for MCF-7 cells) at 37 °C for 3 days.…”