Trinuclear Clusters of Ru/Os without Hydrocarbon Ligands

Osmium Carbonyl Clusters Containing Labile Ligands Hyperstabilize Microtubules

“…Os 3 (CO) 12 (1) was purchased from Oxkem, and the osmium carbonyl clusters Os 3 (CO) 10 (NCCH 3 ) 2 (2) (15) and Os 6 (CO) 16 -(NCCH 3 ) 2 (3) (16) were prepared from 1 according to reported procedures. All other chemicals were purchased from commercial sources and used as supplied.…”

“…We recently reported our evaluation of the anticancer activity of a series of triosmium clusters against five cancer cell lines, including Os 3 (CO) 12 (1), Os 3 (CO) 10 (NCMe) 2 (2), and Os 6 (CO) 16 (NCMe) 2 (3) (Figure 1) (10,11). While 1 showed little cytotoxicity, 2 and 3 exhibited good cytotoxicity against four out of five cancer cell lines tested.…”

“…For instance, dissociation of the two labile acetonitrile (MeCN) ligands from 2 and 3 would afford two vacant coordination sites on the metal centers. Because the chemistry of 2 , in particular, has been extensively explored − , the interesting cytotoxicity exhibited by this class of organometallic compounds prompted us to investigate its biomolecular targets in relation to its known chemistry. We report here our studies carried out with 2 , especially with the MDA-MB-231 cell line.…”