2017
DOI: 10.1016/j.ydbio.2017.07.018
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Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung

Abstract: GW182 (also known asTNRC6) family members are critically involved in the final effector phase of miRNA-mediated mRNA repression. The three mammalian paralogs, TNRC6a, b and c, are thought to be redundant based on Argonaute (Ago) binding, tethering assays, and RNAi silencing of individual members in cell lines. To test this idea, we generated TNRC6a, b and c knockout mice. TNRC6a mutants die at mid-gestation, while b-and c- deleted mice are born at a Mendelian ratio. However, the majority of TNRC6b and all TNRC… Show more

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Cited by 8 publications
(7 citation statements)
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“…Both AGO and TNRC proteins are required for RNA mediated gene silencing and have similarly short ribosomal binding half-lives. Specifically, TNRC6C has two unique motifs AGO binding interactions that are necessary for AGO’s translational repression of mRNAs [ 27 28 ]. This data is supportive of a role for these genes in ASD pathogenesis and may allow some to be reprioritized as high confidence ASD candidate genes and others classified as possible new ASD candidate genes.…”
Section: Resultsmentioning
confidence: 99%
“…Both AGO and TNRC proteins are required for RNA mediated gene silencing and have similarly short ribosomal binding half-lives. Specifically, TNRC6C has two unique motifs AGO binding interactions that are necessary for AGO’s translational repression of mRNAs [ 27 28 ]. This data is supportive of a role for these genes in ASD pathogenesis and may allow some to be reprioritized as high confidence ASD candidate genes and others classified as possible new ASD candidate genes.…”
Section: Resultsmentioning
confidence: 99%
“…There are seven steps to find S. palindrome in SARS0CoV-2 (Figure 1). Step 1: Identification of Dinucleotide S. palindrome In this step four Homozygotes ('The two alleles are in the same state') [19] including 2844 AA, 884 CC, 1091 GG and 3207 TT was recognized. (Table 1) Maximum frequency is 0.399576 (TT) and minimum frequency 0.110142 (CC).…”
Section: Methodsmentioning
confidence: 99%
“…TRIOBP controls cytoskeleton organization and is involved in hearing [45]. Tnrc6b is a protein with repeated glycine/tryptophan residues, may play a role in gene silencing by small interfering-RNAs and microRNAs, and is semi-required for development [46].…”
Section: Pathogenic Pathways Of Hypertension Inferred From the Molecumentioning
confidence: 99%