TRIP13 interference inhibits the proliferation and metastasis of thyroid cancer cells through regulating TTC5/p53 pathway and epithelial-mesenchymal transition related genes expression

Yu, Leitao; Xiao, Yong; Zhou, Xiang; Wang, Jun; Chen, Sunqiang; Peng, Tangyao; Zhu, Xingen

doi:10.1016/j.biopha.2019.109508

Cited by 13 publications

(9 citation statements)

References 32 publications

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“…In this study, through investigating the IUCB and normal tissues of patients, we found that TRIP13 and ZEB1 were highly expressed in IUCB tissues, while E-cad was low expressed. These results are consistent with the previous studies in other cancers [3,4,11,13]. TRIP13 and ZEB1 are highly expressed in tumors [3,4,11], E-cad is lowly expressed in tumors [13].…”

Section: Discussionsupporting

confidence: 93%

“…Recently, more and more studies had focused on the effects of TRIP13 in cancer progression, prognosis, and drug resistance. Down-or lost-expression of TRIP13 can inhibit tumor cells proliferation, migration, and invasion, and promote apoptosis and EMT [3]. In this study, the results of that positive expression of E-cad was negatively associated with TRIP13 or ZEB1 expression.…”

Section: Discussionmentioning

confidence: 49%

“…TRIP13 which can ensure accurate cell division is a marker of centromere-speci c protein. It has been demonstrated that centromere-speci c proteins highly expressed in many tumors which is linked to malignant transformation or instability [3,14]. In this study,we analyzed positive rate of TRIP13 expression in IUCB tissues and control tissues.…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that TRIP13 plays an important role in spindle assembly checkpoint pathway and meiotic recombination [3]. Accumulating researcher had demonstrated that overexpression or ampli cation of TRIP13 should play an important role in many human cancers, such as thyroid cancer [3], colorectal cancer [4], hepatocellular cancer [5], prostate cancer [6], and ovarian cancer [7].…”

Section: Introductionmentioning

confidence: 99%

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Expression of TRIP13, ZEB1, and E-cad in Infiltrating Urothelial Carcinoma of Bladder and Their Clinical Significance

Dai

Zhang

Zhou

2021

Preprint

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Background and purpose: Thyroid hormone receptor interacting protein 13 (TRIP13) which plays a carcinogenic role in tumors belongs to AAA+ ATPase superfamily. Zinc finger E-box binding homeobox 1 (ZEB1) and epithelial cadherin (E-cad), the key biomarkers of epithelial-mesenchymal transition (EMT), which aberrant expression may promote tumor invasion and metastasis. The purpose of this study is to investigate the expression of TRIP13, ZEB1, and E-cad in infiltrating urothelial carcinoma of bladder (IUCB) and their clinicopathological significance.Methods: The expression of TRIP13, ZEB1, and E-cad in 150 cases of IUCB samples were investigated by immunohistochemistry. Clinicopathological, demography, and follow-up data were also collected.Results: Positive rates of expression of TRIP13 and ZEB1 were significantly higher in IUCB samples when compared with the control bladder samples. And positive rate of expression of E-cad was significantly lower in IUCB than its expression rate in the control group. The positive expression of TRIP13 and ZEB1 were positively associated with tumor stages, local lymph node metastasis (LNM), and tumor node metastasis (TNM) stages. And E-cad expression was negatively associated with tumor stages, LNM, and TNM stages. The results of Kaplan-Meier analysis demonstrated that the patients with TRIP13 and ZEB1 positive expression had an unfavorable overall survival (OS) time when compared with patients with TRIP13 and ZEB1 negative expression. And patients with E-cad positive expression had a favorable OS time when compared with patients with E-cad negative expression. The COX regression analysis indicated that TRIP13, ZEB1, and E-cad, tumor stages, as well as TNM stages were independently factors for OS time in IUCB patients with postoperative therapy.Conclusions: TRIP13, ZEB1, and E-cad may be considered as potentially promising biomarkers for IUCB patients’ prognosis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression of TRIP13, ZEB1, and E-cad in Infiltrating Urothelial Carcinoma of Bladder and Their Clinical Significance

Dai

Zhang

Zhou

2021

Preprint

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“…Elevated TRIP13 expression contributes to the malignant transformation of tumor cells. Over‐expression of TRIP13 accelerates the proliferation and invasion of tumors cells, while its knockdown produces antitumor effects 10,35–37 . Increased expression of TRIP13 has been shown to confer chemoresistance to tumor cells 12,23,28 .…”

Section: Discussionmentioning

confidence: 99%

TRIP13 exerts a cancer‐promoting role in cervical cancer by enhancing Wnt/β‐catenin signaling via ACTN4

Liu

Shen

Zhang

2021

Environmental Toxicology

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Increasing evidence has indicated that thyroid hormone receptor interacting protein 13 (TRIP13) exerts a cancer‐promoting role in a broad spectrum of cancers. However, the detailed relevance and function of TRIP13 in cervical cancer remain undefined. The goal of this work was to evaluate the functional significance and mechanism of TRIP13 in cervical cancer. Our data demonstrated that TRIP13 expression was markedly increased in cervical cancer tissue, and high expression of TRIP13 predicted a low survival rate in cervical cancer patients. Knockdown of TRIP13 caused a significant reduction in the proliferation and invasion of cervical cancer cells. By contrast, over‐expression of TRIP13 accelerated the proliferation and invasion of cervical cancer cells. Further data revealed that TRIP13 enhanced the activation of Wnt/β‐catenin signaling associated with modulation of α‐Actinin‐4 (ACTN4). Knockdown of ACTN4 markedly reversed TRIP13‐mediated activation of Wnt/β‐catenin signaling. In addition, inhibition of Wnt/β‐catenin signaling reversed TRIP13‐induced cancer‐promoting effects in cervical cancer cells. Knockdown of TRIP13 markedly retarded the tumor formation and growth of cervical cells in vivo in nude mice. Taken together, the data of this work indicate that TRIP13 accelerates the proliferation and invasion of cervical cancer by enhancing Wnt/β‐catenin signaling via regulation of ACTN4. These findings underscore a relevance of the TRIP13/ACTN4/Wnt/β‐catenin signaling axis in the progression of cervical cancer and suggest TRIP13 as a potential target for treatment of cervical cancer.

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Ultrasound-targeted microbubble destruction (UTMD)-mediated miR-150-5p attenuates oxygen and glucose deprivation-induced cardiomyocyte injury by inhibiting TTC5 expression

et al. 2022

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TRIP13 interference inhibits the proliferation and metastasis of thyroid cancer cells through regulating TTC5/p53 pathway and epithelial-mesenchymal transition related genes expression

Cited by 13 publications

References 32 publications

Expression of TRIP13, ZEB1, and E-cad in Infiltrating Urothelial Carcinoma of Bladder and Their Clinical Significance

Expression of TRIP13, ZEB1, and E-cad in Infiltrating Urothelial Carcinoma of Bladder and Their Clinical Significance

TRIP13 exerts a cancer‐promoting role in cervical cancer by enhancing Wnt/β‐catenin signaling via ACTN4

Ultrasound-targeted microbubble destruction (UTMD)-mediated miR-150-5p attenuates oxygen and glucose deprivation-induced cardiomyocyte injury by inhibiting TTC5 expression

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