Triphlorethol A, a Dietary Polyphenol from Seaweed, Decreases Sleep Latency and Increases Non-Rapid Eye Movement Sleep in Mice

Yoon, Minseok; Cho, Suengmok

doi:10.3390/md16050139

Cited by 20 publications

(11 citation statements)

References 30 publications

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“…Although has being a technique used to analyze crude extracts or fractions, in order to confirm the reliability of spectrophotometric analysis (as discussed above), NMR has been also used in the identification (or confirmation) of isolated phenolic compounds [21,27,156,176], as well as of isolated phlorotannins [32,33,43,45,46,60,62,73,101,115,116,153,154,[177][178][179]184,189,207,[215][216][217]. In fact, NMR analysis has allowed to identify different groups of isolated phlorotannins, in particular, phlorethols, fuhalols, fucols, fucophlorethols, and eckols [32,33,40,43,45,46,60,62,73,153,154,[177][178][179]184,207,[215][216][217].…”

Section: Nmr Analysis Of Isolated Phenolic Compounds From Macroalgae mentioning

confidence: 99%

The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies

et al. 2019

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The current interest of the scientific community for the exploitation of high-value compounds from macroalgae is related to the increasing knowledge of their biological activities and health benefits. Macroalgae phenolic compounds, particularly phlorotannins, have gained particular attention due to their specific bioactivities, including antioxidant, antiproliferative, or antidiabetic. Notwithstanding, the characterization of macroalgae phenolic compounds is a multi-step task, with high challenges associated with their isolation and characterization, due to the highly complex and polysaccharide-rich matrix of macroalgae. Therefore, this fraction is far from being fully explored. In fact, a critical revision of the extraction and characterization methodologies already used in the analysis of phenolic compounds from macroalgae is lacking in the literature, and it is of uttermost importance to compile validated methodologies and discourage misleading practices. The aim of this review is to discuss the state-of-the-art of phenolic compounds already identified in green, red, and brown macroalgae, reviewing their structural classification, as well as critically discussing extraction methodologies, chromatographic separation techniques, and the analytical strategies for their characterization, including information about structural identification techniques and key spectroscopic profiles. For the first time, mass spectrometry data of phlorotannins, a chemical family quite exclusive of macroalgae, is compiled and discussed.

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Section: Nmr Analysis Of Isolated Phenolic Compounds From Macroalgae mentioning

confidence: 99%

The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies

et al. 2019

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“…Other studies found that different polyphenols modulated sleep via GABA receptors. Polyphenols such as phlorotannins [203,204] and triphlorethol A (seaweed polyphenols) [216], red cabbage extracts [217], and kiwifruit extracts [206] decreased SOL and increased sleep duration via GABA receptors in mice. Other polyphenols such as bioflavonoids extracts from Rhus parviflora referred as Tintidikah, a medicinal plant used in south Asia, were the most potent components in decreasing SOL and increasing sleep duration via GABA receptors [205].…”

Section: Mechanisms For the Relationship Between Sleep And Fruit Amentioning

confidence: 99%

Bridging the Reciprocal Gap between Sleep and Fruit and Vegetable Consumption: A Review of the Evidence, Potential Mechanisms, Implications, and Directions for Future Work

2019

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A substantial burden of disease and mortality globally is attributable to both sleep disruption and low intakes of fruit and vegetable (FV) and there is increasing mechanistic and epidemiological evidence to support a reciprocal relationship between the two. This review provides an overview of experimental and observational studies assessing the relations between sleep and FV consumption from 52 human adult studies. Experimental studies are currently limited and show inconsistent results. Observational studies support a non-linear association with adults sleeping the recommended 7–9 hours/day having the highest intakes of FV. The potential mechanisms linking sleep and FV consumption are highlighted. Disrupted sleep influences FV consumption through homeostatic and non-homeostatic mechanisms. Conversely, FV consumption may influence sleep through polyphenol content via several potential pathways. Few human experimental studies have examined the effects of FV items and their polyphenols on sleep and there is a need for more studies to address this. An appreciation of the relationship between sleep and FV consumption may help optimize sleep and FV consumption and may reduce the burden of chronic diseases. This review provides implications for public health and directions for future work.

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“…Triphlorethol A, one of the most important components of phlorotannins, shows a dose-dependent decrease of sleep latency in C57BL/6N mice. Results show that triphlorethol A obtained from seaweed is comparable to zolpidem, a well-known hypnotic drug (Yoon and Cho, 2018).…”

Section: Insomniamentioning

confidence: 90%

Edible Seaweeds: A Potential Novel Source of Bioactive Metabolites and Nutraceuticals With Human Health Benefits

2021

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There has been an increase in human health concerns, and seaweeds are considered as a potential functional food which can decrease the risk of many diseases, as they contain various bioactive compounds. Seaweeds are of nutritional interest and a rich source of natural bioactive compounds including antioxidants, flavonoids, phenolic compounds, and alkaloids that can be used as an alternative source of food material. Seaweeds contain a high amount of vitamins such as A, D, E, C, and B, and minerals including calcium, potassium, magnesium and iron. Seaweeds containing carrageenan, agar and other polysaccharides not only act as a source of fiber but also can act as prebiotics which may benefit the bacteria present in the large intestine. The lack of technologies to process seaweeds for human consumption at an industrial scale is a serious limitation on growth of the seaweed-based functional foods sector. Seaweeds are one of the most extensively used functional foods, with a long history in Asian countries. Now they are also being explored by many Western and European countries. Evidence from epidemiological research suggests that regular consumption of a marine algae-based diet may boost immunity against a number of diseases including COVID-19 novel virus by angiotensin-I-converting enzyme (ACE) inhibition.

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Triphlorethol A, a Dietary Polyphenol from Seaweed, Decreases Sleep Latency and Increases Non-Rapid Eye Movement Sleep in Mice

Cited by 20 publications

References 30 publications

The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies

The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies

Bridging the Reciprocal Gap between Sleep and Fruit and Vegetable Consumption: A Review of the Evidence, Potential Mechanisms, Implications, and Directions for Future Work

Edible Seaweeds: A Potential Novel Source of Bioactive Metabolites and Nutraceuticals With Human Health Benefits

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