Triple antibiotic paste versus propolis: A clinical quest for the reliable treatment of periapical lesions in primary molars

Divya, D; Prasad, Madu Ghanashyam; Radhakrishna, Ambati Naga; Sandeep, R; Reddy, Suravarapu Pavani; Kumar, KR

doi:10.4103/sej.sej_42_18

Cited by 9 publications

(2 citation statements)

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“…Since we face an antibiotic resistance crisis [36] in modern times, it is necessary to consider options that improve, in this case, the antibiotic activity of CTZ compounds, allowing for a possible synergic effect. Some of their advantages are biocompatibility, antioxidant, anti-inflammatory [37], and healing properties [38], as well as being side-effect free [35]. Therefore, the natural therapeutic agent propolis was previously used as a vehicle of TAP, resulting in an improvement of the antimicrobial and regenerative properties [38].…”

Section: Introductionmentioning

confidence: 99%

“…Some of their advantages are biocompatibility, antioxidant, anti-inflammatory [37], and healing properties [38], as well as being side-effect free [35]. Therefore, the natural therapeutic agent propolis was previously used as a vehicle of TAP, resulting in an improvement of the antimicrobial and regenerative properties [38]. The reported action mechanism of natural products is cell wall or membrane destruction, energy synthesis, biofilm formation inhibition, and a production stimulation of reactive oxygen species [39].…”

Section: Introductionmentioning

confidence: 99%

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Propylene Glycol Potentiates the Inhibitory Action of CTZ Paste on Antibiotic-Resistant Enterococcus faecalis Isolated from the Root Canal: An In Vitro Study

Rayos-Verdugo,

Rivera-Chaparro,

Castro-Salazar

et al. 2023

Microorganisms

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This study aimed to evaluate if the change of vehicle for CTZ (Chloramphenicol, Tetracycline, zinc oxide, and Eugenol) paste improves the inhibition of Enterococcus faecalis in vitro. The vehicles evaluated alone and mixed with CTZ were Eugenol, propylene glycol (PG), super-oxidized solution (SOS), grapefruit-seed extract (GSE), and 0.9% saline solution as a negative control. A clinical isolate of E. faecalis was morphologically and biochemically characterized, and its antimicrobial susceptibility was tested using 20 antimicrobial agents. Once characterized, the clinical isolate was cultivated to perform the Kirby–Bauer disc diffusion method with paper discs embedded with the different vehicles mixed or used alone, and incubated at 37 °C for 24 h. Data were analyzed using one-way ANOVA, and the means were compared using Tukey test with a significance level of p < 0.05. For vehicles used alone, GSE presented the greatest inhibition showing a statistically significant difference with the rest of the vehicles. When vehicles were mixed with the CTZ paste, PG showed a greater inhibition with a statistically significant difference from the rest of the vehicles. In conclusion, the vehicle used to mix the CTZ paste plays an important role in the inhibition of E. faecalis in vitro; therefore, we consider that this can be an important factor to achieve success in the use of this technique.

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