Triple combination as adjuvant to cryotherapy in the treatment of solar lentigines: investigator‐blinded, randomized clinical trial

Hexsel, Dóris; Hexsel, Camile L.; Porto, Manoela Donida; Siega, Carolina

doi:10.1111/jdv.12484

Cited by 19 publications

(25 citation statements)

References 27 publications

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“…In most patients a single treatment completely removes the spots and healing is fast. With many other treatments such as cryotherapy or other lasers post-inflammatory hyperpigmentation is a challenge [14]. However, post-laser treatment needs sun-/ultraviolet light-protection and a moisturizer [10].…”

Section: Discussionmentioning

confidence: 99%

Erbium-YAG laser therapy – analysis of more than 1,200 treatments

Wollina¹

2016

Glob Dermatol

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Section: Discussionmentioning

confidence: 99%

Erbium-YAG laser therapy – analysis of more than 1,200 treatments

Wollina¹

2016

Glob Dermatol

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“…Therapeutic options of actinic lentigines can be divided into two main categories: photochemical and topical applications of specific actives . Photochemical treatments include cryotherapy, laser, intense pulsed light and chemical peels . Topical application of specific actives aims at inhibition of melanin production, blockage of melanocyte biostimulation and suppression of melanin delivery to final acceptor cells, not without possible side‐effects .…”

Section: Clinical Indicationsmentioning

confidence: 99%

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Passeron

Genedy

Salah

et al. 2019

Acad Dermatol Venereol

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Background Lasers and intense pulsed light sources (IPLS) are proposed for the treatment of many pigmentary disorders. They are sometimes considered as magic tools able to remove any type of lesions. Although being the best option for several hyperpigmented lesions, they can also worsen some conditions and have potential side‐effects. Objective The aim of this review was to give evidence‐based recommendations for the use of lasers and IPLS in the treatment of hyperpigmented lesions. Methods These recommendations were produced for the European Society of Laser Dermatology by a consensus panel made up of experts in the field of pigment laser surgery. Recommendations on the use of lasers and light treatments were made based on the quality of evidence for efficacy, safety, tolerability, cosmetic outcome, patient satisfaction/preference and, where appropriate, on the experts' opinion. Results Lasers and IPLS are very effective for treating many hyperpigmented lesions such as lentigos, dermal hypermelanocytosis or heavy metal depositions. In the other hand, they have to be considered with great caution for other disorders, such as café au lait macules, melasma or postinflammatory hyperpigmentation. After making the correct diagnosis, if lasers or IPLS are indicated, the optimal wavelengths and parameters will be chosen taking into account the skin phototype, origin and depth of the target pigments. Conclusion Although potentially very effective, lasers and IPLS cannot be proposed for all types of hyperpigmented lesions. In all cases, precise recognition of the disorder is mandatory for choosing between these devices and other therapeutic approaches.

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“…Although cryotherapy has shown good results, patients complain about discomfort during the treatment and unwanted hypopigmentation as a side effect [3,4]. A recent study by Hexsel et al showed a reduction of these adverse effects by combining the cryotherapy with a triple combination cream [5]. Histologically, there is an increased number of pigment granules in the keratinocytes and the condensed stratum corneum [6].…”

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confidence: 99%

Laser treatment of solar lentigines on dorsum of hands: QS Ruby laser versus ablative CO2 fractional laser – a randomized controlled trial

Schoenewolf

Hafner

Dummer

et al. 2015

European Journal of Dermatology

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To cite this article: Schoenewolf NL, Hafner J, Dummer R, Bogdan Allemann I. Laser treatment of solar lentigines on dorsum of hands: QS Ruby laser versus ablative CO 2 fractional laser -a randomized controlled trial. Eur J Dermatol 2015; 25(2): 122-6Background: Lentigines solares (LS) on the dorsum of hands are often esthetically disturbing. Q-switched ruby laser treatment is highly effective in the treatment of these lesions. Ablative fractional photothermolysis may be a suitable alternative. We compared the Q-switched ruby laser with ablative CO 2 fractional photothermolysis for the treatment of solar lentigines. Objective: To evaluate the efficacy and side-effects of 694nm Q-switched ruby laser (Sinon) with the ablative 10,600nm CO 2 fractional laser (Quantel Excel O2) in an intra-individual side-to-side comparison in the treatment of LS on the dorsum of hands. Material and methods: Eleven patients were included in the study. The hands of each patient were randomized for treatment with the two laser systems. Three treatment sessions were scheduled at weeks 0, 4 and 8. Evaluations by patients, treating physician and blinded experts were scheduled at weeks 0, 4, 8, 16 and 24. Results: The Q-switched ruby laser was significantly more efficacious than the ablative CO 2 fractional laser for removing LS on the dorsum of hands (p = 0.01). Conclusion: In this first study on this topic, the Q-switched ruby laser was superior to the ablative CO 2 fractional laser in the treatment of lentigines solares on the dorsum of hands.

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Triple combination as adjuvant to cryotherapy in the treatment of solar lentigines: investigator‐blinded, randomized clinical trial

Cited by 19 publications

References 27 publications

Erbium-YAG laser therapy – analysis of more than 1,200 treatments

Erbium-YAG laser therapy – analysis of more than 1,200 treatments

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Laser treatment of solar lentigines on dorsum of hands: QS Ruby laser versus ablative CO2 fractional laser – a randomized controlled trial

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