Triple-negative breast cancers are increased in black women regardless of age or body mass index

Stead, Lesley; Lash, Timothy L.; J, Sobieraj; Dorcas, D. J.; Westrup, Jennifer; Charlot, Marjory; Blanchard, Rita A.; Lee, John C; King, Thomas C.; Rosenberg, Carol L.

doi:10.1186/bcr2242

Cited by 222 publications

(211 citation statements)

References 51 publications

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“…In our study, ER negative, PR negative and Her2/neu negative receptors constituted 13.2 % of our cases. In previous Indian study revealed 25 % cases of triple-negative breast cancer whereas Western countries have showed 14-30 % of triplenegative breast cancer [9,[31][32][33][34][35]. The negative expressions of triple receptors vary markedly with ethnicity and reported higher in African women as compared to White women [31].…”

Section: Discussionmentioning

confidence: 99%

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Dodiya¹,

Patel²,

Patel³

et al. 2013

Ind J Clin Biochem

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The objective of study was to evaluate and correlate the pathological characteristics of breast cancer patients with estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2/neu) detected by immunohistochemistry and/or fluorescent in situ hybridization method. We have conducted 2 year study of 204 cases of breast cancer at HCG-Medisurge Hospitals, Ahmedabad from 2009 to 2011. Significant correlation was found in ER and PR expression whereas no correlation was found in hormonal receptors and Her2/neu expression. ER and PR positivity increased with advancing age in breast carcinoma patients while not affecting Her2/neu expression. The expression of hormone receptors were higher in infiltrating lobular carcinoma and infiltrating duct carcinoma subtypes of breast carcinoma as compared to other subtypes such medullary and in situ carcinoma. High-grade carcinoma patients were predominantly ER/PR negative and Her2/neu positive as compared to lower grade breast carcinoma whereas high-stage carcinoma patients were ER/PR positive and Her2/neu positive as compared to lower stage breast carcinoma.

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Section: Discussionmentioning

confidence: 99%

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Dodiya¹,

Patel²,

Patel³

et al. 2013

Ind J Clin Biochem

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show abstract

“…This prevalence was higher than that reported in white patients (range, 10%-13%) but was closer to the prevalence reported in African-American patients (range, 23%-30%). 14,30 Few studies have been performed on Hispanics living in the United States. In a small study of 46 patients, the prevalence of TNBC was 10%, 14 although this low prevalence may not be representative because of the small sample size.…”

Section: Discussionmentioning

confidence: 99%

“…14,30 Few studies have been performed on Hispanics living in the United States. In a small study of 46 patients, the prevalence of TNBC was 10%, 14 although this low prevalence may not be representative because of the small sample size. In a subsequent study of 255 patients with TNBC, 49 patients (19.2%) were Hispanic Americans.…”

Section: Discussionmentioning

confidence: 99%

Triple-negative breast cancer in Hispanic patients

Lara‐Medina

Pérez-Sánchez²,

Saavedra-Pérez

et al. 2011

Cancer

173

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“…In developed countries, the majority of the patients have negative lymph nodes. 8,9 Previous Indian studies also have documented a higher proportion of positive axillary nodes at diagnosis.…”

Section: Discussionmentioning

confidence: 93%

Axillary lymph node status, age at presentation and menopausal status in female breast cancer patients attending a government tertiary care teaching hospital in Mysore, Karnataka, India

2017

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Background: Breast cancer is now the leading cause of cancer among Indian women. This study was aimed at creating a database of female breast cancer patients with emphasis on age, menopausal and axillary lymph node metastasis. Methods: A retrospective study was conducted among 103 female breast carcinoma patients who sought treatment in the Department of General Surgery from 2016 January to December. Various data including age at presentation, menopausal status, lymph node status, grade of the tumor, family history of breast cancer, location, size of the tumor and histopathological types were studied. Results: Mean age of the study population was 52.7years. Of the 103 patients, 70.9% were post-menopausal. Among different clinical and pathological variables, Grade of the tumor and menopausal status were showing statistically significant association with positive axillary lymph nodal status. Conclusions: The variables which are predictive of axillary lymph node involvement in breast cancer are tumour grade and menopausal status. The current data may be used to tailor the management protocol of patients with breast carcinoma in this region of the country.

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Triple-negative breast cancers are increased in black women regardless of age or body mass index

Cited by 222 publications

References 51 publications

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Triple-negative breast cancer in Hispanic patients

Axillary lymph node status, age at presentation and menopausal status in female breast cancer patients attending a government tertiary care teaching hospital in Mysore, Karnataka, India

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