Triple negative phenomenon in endometrial cancer: recognition criteria and impact on survival

Bulsa, Michał; Urasińska, Elżbieta

doi:10.5603/gp.a2021.0082

Cited by 2 publications

(5 citation statements)

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“…Assessment of the correlations between changes in organs showed a strong relationship between changes in the endometrium and the mammary gland (r=0.792), moderate -between the cervix and the mammary gland (r=0.634) and strong -between the endometrium and the cervix (r=0.738). Triple-negative mammary gland cancer, characterized by the lack of expression of the estrogen receptor / progesterone receptor (ER/PR) and human epidermal growth factor receptor 2 (HER2), has a worse prognosis compared to mammary gland tumors without this condition [3]. Until recently, systemic treatment for triple-negative cancers was limited to chemotherapy due to the lack of effective targets [13].…”

Section: Resultsmentioning

confidence: 99%

“…The expression of ER and PR markers was assessed using the modified D. Allred scale [3]. Score from 0 to 6 was used to describe the proportion of cells showing positive nuclear staining -A (0= none; 1≤1%; 2=2-9%; 3=10-33%; 4=34-66%; 5>66%), and a score from 0 to 4 represented the intensity of the 22/ Том XXVII / 2 staining -B (0= none; 1=weak; 2=moderate; 3=high).…”

Section: Materials and Methods Of Researchmentioning

confidence: 99%

“…The system for assessing the receptor status of tissues of the female reproductive system proposed by D. Allred and used by us, helps to assess the qualitative and quantitative set of cells expressing ER and PR [3]. Based on the interpretation of the D. Allred scale, it is possible to quantitatively identify cases related to the triple-negative phenomenon.…”

Section: Expression Of Epidermal Growth Factor Hormone Receptors Stan...mentioning

confidence: 99%

“…Precancerous states of the female reproductive system continue to be an actively studied issue despite the successes of recent years, primarily in relation to the prevention of cervical cancer and management of patients with mammary gland neoplasia [1,2]. At the same time, one of the key predictive factors is the characteristics of the receptor set, primarily of the mammary gland and endometrium, namely, receptors for estrogen (ER), progesterone (PR), and epidermal growth factor hormone-2 (HER2) [3]. It is the determination of the receptor status of the tumor tissue that is decisive in the management of cancer patients of a given localization.…”

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confidence: 99%

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Triple-negative transformation of the endometrium, cervix and mammary gland on the background of immunodeficiency

Lytvynenko

Gargin

2022

Med. perspekt.

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Precancerous processes of the female reproductive system continue to be an issue that is being actively studied, despite the successes of recent years. One of the key prognostic factors is the characterization of the receptor set, primarily the mammary gland and endometrium, namely estrogen (ER), progesterone (PR), epidermal growth factor-2 (HER2) receptors. Purpose – to identify the features of the distribution of estrogen, progesterone and epidermal growth factor receptors in the tissues of the endometrium, cervix and mammary gland with a combination of HIV infection and alcohol abuse. Fifty women of reproductive age from 20 to 40 years were studied. After routine conduction and immunohistochemical staining, ER and PR expression were determined by a modified D.Allred scale. HER2 expression was determined by a semi-quantitative method. The obtained digital data were statistically processed. A morphometric study indicates that the combination of HIV infection and alcohol abuse significantly affects the distribution of receptors in the female reproductive system. To a greater extent, the overall score is reduced by reducing the number of cellular elements with the expression of ER and PR. HER2 receptor expression is significantly reduced in the endometrium and mammary gland. These changes may be facilitated by atrophic changes in these organs, which occurs in immunodeficiency. According to the D.Allred scale, the mean score decreases from 5.45±0.63 to 3.10±0.88 in the endometrium, from 4.68±0.65 to 2.47±0.58 in the cervix, from 6.57±0.67 to 3.57±0.77 in the mammary gland (p<0.05). HER2 expression decreased from 3.24±0.47 to 2.21±0.23 in the endometrium, from 3.43±0.66 to 2.36±0.32 in the mammary gland (p<0.05). The development of immunodeficiency is characterized by the restructuring of female reproductive organs with a change in the receptor set of the endometrium, cervix and mammary gland and a decrease in both the qualitative and quantitative composition of the receptors, which may serve as a prerequisite for the development of a triple-negative phenomenon in tumors of these organs.

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Section: Resultsmentioning

confidence: 99%

Section: Materials and Methods Of Researchmentioning

confidence: 99%

Section: Expression Of Epidermal Growth Factor Hormone Receptors Stan...mentioning

confidence: 99%

mentioning

confidence: 99%

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Triple-negative transformation of the endometrium, cervix and mammary gland on the background of immunodeficiency

Lytvynenko

Gargin

2022

Med. perspekt.

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“…There are different criteria for diagnosing triple-negative endometrial cancer [13][14][15][16][17][18]. In our study, we have compared TNP criteria (H-SCORE < 75, H-SCORE < 50 and Allred scale) and its impact on survival [19]. Based on that study, we compare herein the PARP-1 protein expression in endometrial cancer for triple-negative (TNEC) and non-triple-negative (NTNEC) endometrial cancer patients and determine the relationship between the PARP-1 protein expression in endometrial cancer cells and patients' overall survival (OS) depending on the adopted scale (H-SCORE < 75, H-SCORE < 50, Allred scale).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical expression of PARP-1 in triple-negative endometrial cancer – a comparison of different score systems

Bulsa¹,

Jankowska-Szabłowska²,

Urasińska³

2022

pjp

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Endometrial cancer is the most common malignant neoplasm of the female reproductive system. The number of diagnosed cases is increasing every year. In recent years, the triple-negative phenomenon (TNP) has been identified as one of the determinants of shorter survival in endometrial cancer patients. The aim of the study was to compare the PARP-1 protein expression in triple-negative (TNEC) and non-triple-negative (NTNEC) endometrial cancer patients and determine the relationship between the PARP-1 protein expression in endometrial cancer cells and patient's overall survival depending on the adopted scale (H-SCORE < 75, H-SCORE < 50, Allred scale). The study involved 265 patients with histopathologically confirmed endometrial cancer. The patients were divided into 2 groups: patients with TNEC and patients with NTNEC. The study was conducted using a tissue microarray technique. Expression of PARP-1 protein was determined by immunohistochemistry. Protein expression evaluation was performed using virtual microscopy and the Image Scope computer image analysis system. The following conclusions were reached: total and individual levels of nuclear or cytoplasmic PARP-1 expression varied with the presence or absence of TNP, and PARP-1 nuclear expression at the 2+ level had a significant effect on the increased risk of death (according to H-SCORE < 75).

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Triple negative phenomenon in endometrial cancer: recognition criteria and impact on survival

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Ginekologia Polska" are listed in PubMed.

Cited by 2 publications

References 30 publications

Triple-negative transformation of the endometrium, cervix and mammary gland on the background of immunodeficiency

Triple-negative transformation of the endometrium, cervix and mammary gland on the background of immunodeficiency

Immunohistochemical expression of PARP-1 in triple-negative endometrial cancer – a comparison of different score systems

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