Triple or Quadruple Tetracycline-Based Therapies Versus Standard Triple Treatment for Helicobacter pylori Treatment

Songür, Yıldıran; Senol, Altug; Balkarlı, Ayşe; Baştürk, Abdulkadir; Çerçi, Süreyya

doi:10.1097/maj.0b013e31819c7320

Cited by 31 publications

(23 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After detailed review of selected articles, 12 RCTs [8,9,10,11,12,13,14,15,16,17,18,19] with 2,753 patients fulfilled the inclusion criteria of the meta-analysis (fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis of Bismuth Quadruple Therapy versus Clarithromycin Triple Therapy for Empiric Primary Treatment of Helicobacter pylori Infection

Venerito

Krieger²,

Ecker³

et al. 2013

Digestion

151

114

View full text Add to dashboard Cite

Background: In areas with high clarithromycin resistance, bismuth quadruple therapy (BQT) is recommended instead of clarithromycin triple therapy (CTT) as the first-line treatment for Helicobacter pylori eradication. Methods: Randomized clinical trials (RCTs) comparing BQT to CTT were identified through electronic and manual searches. A meta-analysis was performed to compare the efficacy and tolerability of these two regimens as first-line treatments for H. pylori infection. The effect of antibiotic resistance on treatment efficacy was also analyzed. Results: Twelve RCTs were included. BQT achieved eradication in 77.6% of patients, whereas CTT achieved an eradication rate of 68.9% [risk difference (RD) = 0.06, 95% CI: -0.01/0.13]. A high heterogeneity among the trials was found (χ² = 50.16, p < 0.00001; I² = 78%). In the subgroup analysis for treatment duration, the 10-day BQT was more effective than the 7-day CTT (RD = 0.25, 95% CI: 0.18/0.32), whereas no differences were observed between CTT and BQT given for 7 or 10 days. There were no statistical differences in side effects and compliance between both therapies (RD = 0.92, 95% CI: 0.76/1.12, and RD = -0.03, 95% CI: -0.05/0.00, respectively). The effect of antibiotic resistance on eradication rates was reported in 4 of the 12 RCTs. Clarithromycin resistance significantly affected the efficacy of CTT (RD = 0.75, 95% CI: 0.63/0.87), whereas BQT efficacy was not affected by metronidazole resistance (RD = 0.09, 95% CI: -0.06/0.25). Conclusions: The 10-day BQT was more effective than the 7-day CTT as a first-line therapy for H. pylori infection, whereas BQT and CTT for 7 or 10 days yielded similar eradication rates. Compliance and side effect rates were similar for both therapies. BQT overcomes clarithromycin resistance and its efficacy is not affected by metronidazole resistance.

show abstract

“…After detailed review of selected articles, 12 RCTs [8,9,10,11,12,13,14,15,16,17,18,19] with 2,753 patients fulfilled the inclusion criteria of the meta-analysis (fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis of Bismuth Quadruple Therapy versus Clarithromycin Triple Therapy for Empiric Primary Treatment of Helicobacter pylori Infection

Venerito

Krieger²,

Ecker³

et al. 2013

Digestion

151

114

View full text Add to dashboard Cite

show abstract

“…In a pooled analysis of anti-H. pylori treatment regimens, clarithromycin based triple regimens with 76%-85% eradication rate have been considered the most effective anti-H. pylori therapeutic strategies (7,18,25 In more recent studies, bismuth based quadruple therapy has been best in regards to eradication rate, probably due to the emergence of macrolid resistant strains (25). Eradication rate in another study has been as low as 35.6% (26). The most acceptable duration has been determined to be between ten and fourteen days (25,27).…”

Section: Discussionmentioning

confidence: 99%

Azithromycin based triple therapy versus standard clarithromycin based triple therapy in eradication of Helicobacter pylori infection in Iran: a randomized controlled clinical trial

Sarkeshikian¹,

Iranikhah²,

Ghadir³

2009

Turk J Gastroenterol

View full text Add to dashboard Cite

clarithromycin, amoxicillin, and omeprazole and azithromycin, amoxicillin, and omeprazole, respectively, and completed the study course. Per protocol, eradication rate was 83% with clarithromycin, amoxicillin, and omeprazole and 75% with azithromycin, amoxicillin, and omeprazole (p =0.158). Eradication rate for a subgroup of patients with peptic ulcer disease in two groups were 83% and 74%, respectively (p=0.134

show abstract

“…The efficacy of H. pylori eradication strategies, the appropriate length of treatment and the cost effectiveness, all appear controversial [13][14][15][16]. Further reports in literature have devaluated the triple therapy and suggested a quadruple one [17].…”

Section: Discussionmentioning

confidence: 99%

The Dramatic Spread of Diabetes Mellitus Worldwide and Influence of Helicobacter pylori

Nasrat¹

2014

General Med

View full text Add to dashboard Cite

Objective: Demonstration of an influence of Helicobacter pylori in the dramatic spread of Diabetes mellitus (DM) among many patients during the last two decades. Background:The flare up of a lot of medical challenges related to H. pylori through immune or different unknown reasons made the medical world believe that H. pylori eradication should be a necessary attempt. These H. pylorirelated medical problems are sufficient to render the matter that H. pylori can reside hidden somewhere in the body be taken seriously. The spread of DM is rising in a dramatic way as the fire spreading in hey especially in developing countries giving the term "diabetic epidemic" an actual credibility. H. pylori could migrate or get forced to migrate to the colon leading to accumulation of profuse toxic amounts of ammonia unopposed or buffered by any acidity leading to biological stress to the body that could predispose to stress diabetes among disadvantaged susceptible people.

show abstract

Triple or Quadruple Tetracycline-Based Therapies Versus Standard Triple Treatment for Helicobacter pylori Treatment

Cited by 31 publications

References 15 publications

Meta-Analysis of Bismuth Quadruple Therapy versus Clarithromycin Triple Therapy for Empiric Primary Treatment of Helicobacter pylori Infection

Meta-Analysis of Bismuth Quadruple Therapy versus Clarithromycin Triple Therapy for Empiric Primary Treatment of Helicobacter pylori Infection

Azithromycin based triple therapy versus standard clarithromycin based triple therapy in eradication of Helicobacter pylori infection in Iran: a randomized controlled clinical trial

The Dramatic Spread of Diabetes Mellitus Worldwide and Influence of Helicobacter pylori

Contact Info

Product

Resources

About