“…3,30,[33][34][35][36] Moreover, compared with pharmacologic options for downregulating risk, lifestyle interventions are at least comparably, and perhaps more, effective with the added advantages of mitigating multiple behavioral and medical hazards (eg, mood problems and cardiometabolic derangements) simultaneously in both children and adults across the risk range without the contraindications and potential side-effects associated with many commonly prescribed medications. 1,2,8,15,31,33,[39][40][41][42][43][44][45][46] To paraphrase one variant on a popular observation recently elaborated by Lipsky and Sharp, 35 any pharmaceutical with the risk/benefit ratio of lifestyle modification surely would be patented as a novel blockbuster guaranteed to revolutionize diabetes prevention and intervention.…”