2024
DOI: 10.1002/cbdv.202301898
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Tris‐Functionalized Polyoxotungstovanadate‐Mediated Antitumor Efficacy Involves Multiple Cell Death Pathways

Lihong Chen,
Zijia Zhao,
Rominah Onintsoa Diarimalala
et al.

Abstract: Polyoxometalates (POMs) are promising inorganic drug candidates for cancer chemotherapy. They are becoming attractive because of their easy accessibility and low cost. Herein, we report the synthesis and antitumor activity studies of four Lindqvist‐type POMs with mixed‐addenda atoms Na2[V4W2O16{(OCH2)3CR}] (R= ‐CH2OH, ‐CH3, ‐CH2CH3) and (Bu4N)2[V3W3{(OCH2)3CH2OOCCH2CH3}]. Compared with the current clinical applied antitumor drug 5‐fluorouracil (5‐FU) or Gemcitabine, analysis of MTT/CCK‐8 assay, colony formatio… Show more

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