Triterpene benzoates from the bark of Picramnia teapensis (Simaroubaceae)

Rodrı́guez-Gamboa, Tatiana; Fernandes, João B.; Filho, Édson Rodrigues; Silva, M. Fátima das G. F. da; Vieira, Paulo; Barrios, Mariano; Castro-Castillo, Oscar; Victor, Sandra R.; Pagnocca, Fernando Carlos; Bueno, Odair Corrêa; Hebling, M. J. A.

doi:10.1590/s0103-50532001000300010

Cited by 11 publications

(6 citation statements)

References 8 publications

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“…In addition, were also isolated and their structures elucidated of two benzoic acid esters of epibetulinic acid, 3,7-dibenzoate of epi-betulinic acid and 7-benzoate of epi-betulinic acid. 73…”

Section: P Teapensismentioning

confidence: 99%

A Short Review of the Picramnia Genus

Medel,

Tirado,

Ventura

2024

Meio Ambiente: Tendências, Estudos E Abordagens

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Explorando temas como erosão hídrica, bioatividade e antraquinonas, nosso ebook "Meio Ambiente: Tendências, Estudos e Abordagens vol.01" oferece uma visão prática e abrangente das dinâmicas ambientais. Com o objetivo de proporcionar uma compreensão mais clara e consciente, cada capítulo não apenas aborda desafios ambientais, mas também apresenta soluções inovadoras e estratégias práticas.Agradecemos calorosamente a cada autor por sua contribuição valiosa a este e-book. Esperamos que esse trabalho inspire outros pesquisadores e acadêmicos a compartilharem suas perspectivas, fortalecendo assim o diálogo acadêmico e a compreensão das questões ambientais." SUMÁRIO

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Section: P Teapensismentioning

confidence: 99%

A Short Review of the Picramnia Genus

Medel,

Tirado,

Ventura

2024

Meio Ambiente: Tendências, Estudos E Abordagens

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“…The genera Picramnia and Alvaradoa, despite occasionally reported as constituents of the Simaroubaceae family (Balderrama et al, 2001;Rodríguez-Gamboa et al, 2001;Cortadi et al, 2010), were excluded from it and put into the Picramniaceae family by Fernando and collaborators (1995). This translocation is supported by the fact that Picramnia and Alvaradoa are phytochemically characterized by a vast presence of anthraquinones and anthracenic derivates in comparison to quassinoids, the taxonomic markers of the Simaroubaceae family (Diaz et al, 2004).…”

Section: Botanymentioning

confidence: 99%

Simaroubaceae family: botany, chemical composition and biological activities

Alves

Miranda

Soares

et al. 2014

Revista Brasileira de Farmacognosia

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“…Picramnia species (Picramniaceae, previously Simaroubaceae) are commonly used in folk medicine to treat or prevent dermatosis, external ulcers (sores), and skin irritations [ 4 ]. Phytochemical investigation in some of these Picramnia species resulted in isolation of several metabolites [ 5 , 6 ], mainly triterpenes [ 7 – 9 ], anthrones and anthraquinone glycosides [ 10 – 14 ], and oxanthrones [ 10 – 12 , 15 ] with cytotoxic, antimicrobial, antifungal, or antiparasitic activities [ 16 – 18 ]. Picramnia gracilis Tul.…”

Section: Introductionmentioning

confidence: 99%

Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone ofPicramnia gracilisTul. (Picramniaceae) Fruit:In VitroandIn VivoStudies

Robledo

Cardona

Ligardo

et al. 2015

Advances in Pharmacological Sciences

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Species of Picramnia genus are used in folk medicine to treat or prevent skin disorders, but only few species have been studied for biological activity and chemical composition. P. gracilis Tul. is a native species from Central and South America and although its fruits are edible, phytochemical analysis or medicinal uses of this species are not known. In the search of candidates to antileishmanial drugs, this work aimed to evaluate the antileishmanial activity of P. gracilis Tul. in in vitro and in vivo studies. Only ethanolic extract of fruits showed leishmanicidal activity. The majoritarian metabolite was 5,3′-hydroxy-7,4′-dimethoxyflavanone ether that exhibited high activity against L. (V.) panamensis (EC50 17.0 + 2.8 mg/mL, 53.7 μM) and low toxicity on mammalian U-937 cells, with an index of selectivity >11.8. In vivo studies showed that the flavanone administered in solution (2 mg/kg/day) or cream (2%) induces clinical improvement and no toxicity in hamsters with CL. In conclusion, this is the first report about isolation of 5,3′-hydroxy-7,4′-dimethoxyflavanone of P. gracilis Tul. The leishmanicidal activity attributed to this flavanone is also reported for the first time. Finally, the in vitro and in vivo leishmanicidal activity reported here for 5,3′-hydroxy-7,4′-dimethoxyflavanone offers a greater prospect towards antileishmanial drug discovery and development.

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Triterpene benzoates from the bark of Picramnia teapensis (Simaroubaceae)

Cited by 11 publications

References 8 publications

A Short Review of the Picramnia Genus

A Short Review of the Picramnia Genus

Simaroubaceae family: botany, chemical composition and biological activities

Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone ofPicramnia gracilisTul. (Picramniaceae) Fruit:In VitroandIn VivoStudies

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