Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity

Ding, Yan; Liang, Chun; Kim, Jun Ho; Lee, Young-Mi; Hyun, Jae‐Hee; Kang, Hee‐Kyoung; Kim, Jeong Ah; Min, Byung Sun; Kim, Young Ho

doi:10.1016/j.bmcl.2010.01.096

Cited by 43 publications

(21 citation statements)

References 15 publications

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“…We assumed that eicosanoic acid, friedelin and arjunolic acid may be the main compounds in the protective effects of UME (Miles et al 2002;Ding et al 2010;Ghosh et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of Ulmus macrocarpa on experimental colitis mice models

Park

Bae

et al. 2011

Orient Pharm Exp Med

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In traditional Korean medicine, Ulmus macrocarpa Hance is a frequently used herb in South Korea for treating intestinal disorders such as colitis. This study investigated whether water extract of Ulmus macrocarpa Hance (UME) could show a protective action on 2 different mice models of experimental colitis induced by dextran sulfate sodium (DSS) and 2,4,6-trinitrobenzenesulfonic acid (TNBS), which have been widely used as inflammatory bowel disease models. Colitis was induced by DSS and TNBS in balb/c mice, respectively. UME at doses of 100, 300, or 1000 mg/kg was orally administered twice a day for 7 d in the DSS model and at doses of 300 or 1000 mg/kg for 3 d in the TNBS model. The body weight of the mice and clinical score were measured daily. Colon length and macroscopic score were assessed on day 7 in the DSS model and on day 3 in the TNBS model. In the DSS model, UME inhibited shortening of colon length and macroscopic damages of the colon, and showed improvement of clinical score, however it did not inhibit weight loss. In the TNBS model, UME did not inhibit weight loss and shortening of colon length. The current results indicate that UME ameliorates DSS-induced colitis in mice similar to human ulcerative colitis, not TNBSinduced colitis in mice similar to human Crohn's disease. Further investigations to unveil the exact mechanisms are needed.

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“…We assumed that eicosanoic acid, friedelin and arjunolic acid may be the main compounds in the protective effects of UME (Miles et al 2002;Ding et al 2010;Ghosh et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of Ulmus macrocarpa on experimental colitis mice models

Park

Bae

et al. 2011

Orient Pharm Exp Med

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“…Rutin, the major constitutional flavonoid in fraction C, was extremely effective in the anti-inflammatory assay (Gaitén et al, 2011) and was suggested to be another anti-inflammatory constituent. 13-Tetradecenal (7), (Z,Z)-9,12-octadecadienoic acid (8), (3α)-12-oleanen-3-yl acetate (9), and (þ )-3-oxo-urs-12-en-24-oic acid methyl ester (10) were identified to be the major hydrophobic constituents in the active fraction E. The reported anti-inflammatory effects of compounds 8 (Morikawa et al, 2006) and 9 (Ding et al, 2010) suggested both compounds to be the anti-inflammatory constituents of fraction E, but whether compounds 7 and 10 also have the anti-inflammatory effect is still unknown. Besides, since only the volatile compounds could be detected in GC-MS, and many hydrophobic constituents present in the fraction E showed observable UV peaks in its UHPLC-DAD chromatogram (see Fig.…”

Section: Disscusion and Conclusionmentioning

confidence: 97%

Identification of anti-inflammatory constituents from Kalimeris indica with UHPLC-ESI-Q-TOF-MS/MS and GC–MS

Zhong¹,

Xu²,

Wang³

et al. 2015

Journal of Ethnopharmacology

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“…Glutinol has a powerful analgesic and a moderate anti-inflammatory activity [17,18]. The activity of 7-hydroxybaruol is not known.…”

Section: Discussionmentioning

confidence: 99%

<b><i>Adenostoma fasciculatum</i></b>, California Chamise: Chemistry and Use in Skin Conditions

Bouttemy¹,

Filho²,

Adams³

et al. 2014

Integr Med Int

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Adenostoma fasciculatum is used traditionally to treat skin conditions such as eczema. The plant was found to contain monoterpenoids, including hydroquinone and geranial. Other terpenoids were found, including the triterpenoids 7α-hydroxybaruol and glutinol, the diterpenoids thalianol and thaliandiol as well as the steroids suberosol and campesterol. The new compound, 7α-hydroxybaruol, was further analyzed by two-dimensional nuclear magnetic resonance (NMR) imaging, ¹³C NMR and high-resolution high-performance liquid chromatography combined with mass spectrometry. A balm was made from the plant with olive oil and bees wax. Several patients tried the balm and reported improvements in Adams disease, eczema symptoms and seborrhea within 1 week.

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Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity

Cited by 43 publications

References 15 publications

Protective effects of Ulmus macrocarpa on experimental colitis mice models

Protective effects of Ulmus macrocarpa on experimental colitis mice models

Identification of anti-inflammatory constituents from Kalimeris indica with UHPLC-ESI-Q-TOF-MS/MS and GC–MS

<b><i>Adenostoma fasciculatum</i></b>, California Chamise: Chemistry and Use in Skin Conditions

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