Triterpenoids (1999)

Connolly, Joseph D.; Hill, Robert A.

doi:10.1039/b104602k

Cited by 35 publications

(16 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8 Terpenoids composed of isoprenoid units constitute one of the largest groups of natural products, accounting for more than 40,000 individual compounds, with several new compounds being discovered annually. [9][10][11] Terpenoids have been reported to be useful in the prevention and therapy of several diseases, including cancer, and to have antimicrobial, antifungal, antiparasitic, antiviral, antiallergenic, antispasmodic, antihyperglycemic, antiinflammatory, and immunomodulatory properties. [12][13][14] Numerous preclinical efficacy studies have extensively evidenced that both natural and synthetic derivatives of triterpenoids possess chemopreventive and therapeutic effects against colon, 15 breast, 16 and prostate and skin cancers.…”

mentioning

confidence: 99%

Nimbolide induces apoptosis in human nasopharyngeal cancer cells

Chien

Hsu

Lin

et al. 2017

Environmental Toxicology

View full text Add to dashboard Cite

Nasopharyngeal carcinoma (NPC), a tumor arising from epithelial cells that cover the surface and line the nasopharynx, is a rare malignancy worldwide but is prevalent in certain geographical areas, such as Southern Asia (Taiwan, Hong Kong, Singapore, Malaysia, and Southern China) and North Africa. Despite advances in diagnostic techniques and improvements in treatment modalities, the prognosis of NPC remains poor. Therefore, an effective chemotherapy regimen that enhances tumor sensitivity to chemotherapeutics is urgently required. Nimbolide, derived from Azadirachta indica, has a wide range of beneficial effects, including anti-inflammatory and anticancer properties. The present study evaluated the antitumor activity of nimbolide in NPC cells and its underlying mechanisms. Our results revealed that the treatment of HONE-1 cells with nimbolide potently inhibited cell viability. Moreover, nimbolide led to cell cycle arrest, which subsequently activated caspase-3, -8, and -9 and poly (ADP-ribose) polymerase to induce cell apoptosis. Moreover, nimbolide induced Bik, Bax, and t-Bid expression in HONE-1 cells. The results indicated that nimbolide induces apoptosis through the modulation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathways. Nimbolide induces apoptosis in human NPC cells and is a potential chemopreventive agent against NPC proliferation. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 2085-2092, 2017.

show abstract

mentioning

confidence: 99%

Nimbolide induces apoptosis in human nasopharyngeal cancer cells

Chien

Hsu

Lin

et al. 2017

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…Triterpenoids represent a broad category of molecules ubiquitously present in the plant kingdom1617, and used widely in Asian medicine (usually in the form of herbal extracts)18. Among these natural triterpenoids, the natural pentacyclic triterpene oleanolic acid (OA) displays numerous biological properties with therapeutic potential1819.…”

mentioning

confidence: 99%

Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis

Pareek

Belkadi

Kesavapany

et al. 2011

Sci Rep

View full text Add to dashboard Cite

Inflammatory cytokines and endogenous anti-oxidants are variables affecting disease progression in multiple sclerosis (MS). Here we demonstrate the dual capacity of triterpenoids to simultaneously repress production of IL-17 and other pro-inflammatory mediators while exerting neuroprotective effects directly through Nrf2-dependent induction of anti-oxidant genes. Derivatives of the natural triterpene oleanolic acid, namely CDDO-trifluoroethyl-amide (CDDO-TFEA), completely suppressed disease in a murine model of MS, experimental autoimmune encephalomyelitis (EAE), by inhibiting Th1 and Th17 mRNA and cytokine production. Encephalitogenic T cells recovered from treated mice were hypo-responsive to myelin antigen and failed to adoptively transfer the disease. Microarray analyses showed significant suppression of pro-inflammatory transcripts with concomitant induction of anti-inflammatory genes including Ptgds and Hsd11b1. Finally, triterpenoids induced oligodendrocyte maturation in vitro and enhanced myelin repair in an LPC-induced non-inflammatory model of demyelination in vivo. These results demonstrate the unique potential of triterpenoid derivatives for the treatment of neuroinflammatory disorders such as MS.

show abstract

“…Two new long-chain alkanoic acid esters of lupeol were isolated together with amyrins, cycloartenol and lupeol from Brazilian propolis produced with resin collected from Baccharis trimera plants (Furukawa et al, 2002). There has been continued interest in the biological activity of triterpenoids and triterpenoid saponins toward sweetness and anti-HIV, hypoglycaemic, hypotensive, hypocholesterolaemic, antiatherosclerotic and antithrombotic activities (Connolly & Hill, 2001). Lupeol has been shown to have pharmacological activity, especially as an anti-inflammatory agent (Fernandez et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Compound identification was accomplished using computer searches over the library Wiley 275L. Identification of triterpenoids relied on published data of mass spectroscopy (Shiojima et al, 1992;Connolly & Hill, 2001), by comparison with mass spectra of the sample constituents. Whenever available, reference compounds were co-chromatographed to aid in the identification.…”

Section: Gc/eims and Identification Of Compoundsmentioning

confidence: 99%