Triterpenoids from Dysoxylum genus and their biological activities

Naini, Al Arofatus; Mayanti, Tri; Supratman, Unang

doi:10.1007/s12272-022-01371-9

Cited by 22 publications

(25 citation statements)

References 67 publications

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“…In addition, the standard inhibitor of cancer (doxorubicin) [2] was also tested as the reference under the same condition. All the compounds (1-2) gave the IC 50 values of 60.87 and 72.86 µM (Table 2 and Table S1, S2), respectively, which were classified as moderate cytotoxic [40]. In general, the resulted IC 50 was roughly higher by two times than the positive control.…”

Section: ■ Results and Discussionmentioning

confidence: 95%

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Triterpenoids from Stem Bark of <i>Dysoxylum excelsum</i> and Their Cytotoxic Activity against MCF-7 Breast Cancer Cells

Meilanie

Mayanti²,

Nurlelasari³

et al. 2022

Indones. J. Chem.

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The diversity of structures of triterpenoids provides a variety of interesting pharmacological effects, one of them being anticancer. Sources of triterpenoids are found in Dysoxylum excelsum, it is still rarely studied, and it potentially contains triterpenoids with cytotoxic activity. Therefore, the research aimed to isolate the triterpenoids from the stem bark of D. excelsum and determine their cytotoxic efficacy against the breast cancer cells of MCF-7. The dried stem bark of D. excelsum was macerated using methanol and then fractionated with n-hexane and ethyl acetate to obtain the corresponding fractions. Two triterpenoids, 3α,7α-dihydroxyapotirucalla-14,24-Z-dien-26-oic acid (1) and masticadienonic acid or 3-oxo-tirucalla-7,24-Z-dien-26-oic acid (2) were isolated in the first place from the Dysoxylum genus. Compounds 1 and 2 were assayed for their cytotoxic potency anti- MCF-7 using the MTT assay and gave moderate IC50 values of 60.87 and 72.86 µM, respectively. Based on their analogs, partial structure modification of the compounds might increase the activity; thus, it can be further utilized as better lead compounds for anticancer drugs candidate.

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Section: ■ Results and Discussionmentioning

confidence: 95%

“…Furthermore, five apotirucallanes exhibited moderate cytotoxic activities against MCF-7 at an IC 50 range of 78.7-85.8 μΜ [23]. The SAR analysis showed that the occurrence of an aromatic heterocyclic such as pyrrole in the side chain combined with 3α-OH substituents influenced mostly the potent cytotoxicity [40].…”

Section: ■ Results and Discussionmentioning

confidence: 97%

Triterpenoids from Stem Bark of <i>Dysoxylum excelsum</i> and Their Cytotoxic Activity against MCF-7 Breast Cancer Cells

Meilanie

Mayanti²,

Nurlelasari³

et al. 2022

Indones. J. Chem.

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“…Furthermore, fraction 2 was subjected to LCMS profiling and HPLC purification. For further purification, the active fraction was analyzed by HPLC, and the same method was used to get pure compounds (1)(2)(3)(4). The isolation was performed using analytical HPLC, where the mobile phase consisted of acetonitrile and 0.1% acetic acid in water at a flow rate of 1 mL min À1 for a total run time of 16 min in isocratic mode of acetonitrile and 0.1% acetic acid in water (65 : 35), where the fraction collector was adjusted to time intervals of 0-2.5, 2.6-5.0, 5.1-7.5, 5.1-7.5, 10-12.5, and 12.5-15.0 min.…”

Section: Extraction and Isolationmentioning

confidence: 99%

Isolation of cytotoxic cycloartane triterpenoids from Dysoxylum malabaricum

Bhardwaj,

Sharma,

Tripathi

et al. 2024

New J. Chem.

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“…3 Furthermore, the genus Dysoxylum (Meliaceae) comprises approximately 200 species distributed in Australia, New Zealand, India, Indonesia, and Southeast Asia. 4,5 Its previous phytochemical studies led to the reports of an array of products, including sesquiterpenoids, 6,7 diterpenoids, 8 triterpenoids as the major compound, 5 steroids, 9 and alkaloids, 10 which exhibit diverse biological effects.…”

Section: Introductionmentioning

confidence: 99%