Triterpenoids of Paeonia japonica callus tissue

Ikuta, Akira; Itokawa, Hideji

doi:10.1016/0031-9422(88)80668-x

Cited by 111 publications

(59 citation statements)

References 6 publications

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“…On the basis of the above spectral features, compound 3 was identified as betulinic acid. The identity of 3 as betulinic acid was confirmed by comparison of these data with published values (Ikuta and Itokawa, 1988) as well as by co-TLC with an authentic sample.…”

Section: Resultssupporting

confidence: 54%

Chemical and biological investigations of Dillenia indica Linn.

Parvin

Rahman

Islam

et al. 2009

Bangladesh J Pharmacol

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Section: Resultssupporting

confidence: 54%

Chemical and biological investigations of Dillenia indica Linn.

Parvin

Rahman

Islam

et al. 2009

Bangladesh J Pharmacol

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“…Cholesteryl oleate was recovered in the upper heptane phase (total volume 0.9-1.0 ml). The radioactivity in 100 ml of the upper phase was measured in scintillation vial with 3 ml of scintillation cocktail (Lipoluma, Lumac Co.) using a liquid scintillation counter (1450 Microbeta Trilux Wallac Oy, Turku, Finland) to detect the radioactivity of the cholesteryl [1][2][3][4][5][6][7][8][9][10][11][12][13][14] C] oleate. Background values were obtained by preparing heat inactivated microsomes.…”

Section: )mentioning

confidence: 99%

Human ACAT-1 and ACAT-2 Inhibitory Activities of Pentacyclic Triterpenes from the Leaves of Lycopus lucidus TURCZ.

Lee

Park

et al. 2006

Biological & Pharmaceutical Bulletin

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“…The known compounds, (2S)-5,7,3Ј,4Ј-tetrahydroxyfla- 3) 5,7-dihydroxychromone (14), 10) 5-hydroxychromone-7-O-glucoside (15), 10) methyl-3-O-feruloylquinate (16), 11) 4-O-cinnamoylquinic acid (17), 3) oleanolic acid (18), 3) betulinic acid (19), 12) b-amyrin acetate (20), 3) lupeol (21), 13) b-sitostenone (22), 14) stigmasterol (23)ϩb-sitosterol (24) mixtures, 15) 15) cinnamic acid (27), 16) coumaric acid (28), 15) ferulic acid (29), 15) caffeic acid (30), 15) 4-hydroxybenzaldehyde (31), 3) 4-hydroxybenzoic acid (32), 3) vanillin (33), 3) vanillic acid (34), 17) protocatechuic acid (35), 3) syringaldehyde (36), 17) acetovanillone (37), 18) 2,6-dimethoxy-p-benzoquinone (38), 19) 2-deoxyepi-inositol (39), 3) thymine (40) 20) and uracil (41) 21) were also isolated and identified by comparison of their spectral data with corresponding literature values.…”

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confidence: 99%

The Inhibition of Superoxide Anion Generation in Human Neutrophils by Viscum coloratum

et al. 2006

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In clinical use, Taxillus genus plants could be placed by Viscum genus plants. But, they belong to different genera of Loranthaceae. The genus of Viscum, the plants of Loranthaceae family, are photosynthetic shrubby, hemiparasites on the tree branches. Viscum coloratum has commonly been used for Chinese medicine as a curative for a number of ailments such as hemorrhage, pleurisy, gout, heart disease, epilepsy, arthritis and hypertension.1,2) In our research, we found oleanolic acid showed significantly anti-inflammatory activitiy in V. articulatum.3) Oleanolic acid concentration-dependently inhibited superoxide anion generation by human neutrophils in response to fMLP (formyl-L-methionyl-Lleucyl-L-phenylalanine), but not to PMA (phorbol myristate acetate). It suggested that the inhibitory effect of oleanolic acid was through protein kinase C-independent pathway.In a previous screening for the inhibitory activities on superoxide anion generation in fMLP-stimulated human neutrophils by Viscum and Taxillus medicinal plants, V. coloratum also exhibited the strong inhibition. From V. coloratum, two new and thirty-nine known compounds were isolated and characterized. This paper deals with the structural determination of two new compounds, viscolin (4Ј,4Љ-dihydroxy-2Ј,3Ј,6Ј,3Љ-tetramethoxy-1,3-diphenylpropane) (1) and (2S)-7,4Ј-dihydroxy-5,3Ј-dimethoxyflavanone (2) by spectral analysis. The inhibitory activities of crude extract and pure compounds on neutrophils stimulated by fMLP/CB were also tested. Results and DiscussionThe crude extract and partitioned layers were examined for their anti-inflammatory effect using neutrophils. The chloroform soluble layer revealed significantly anti-inflammatory activities and the butanol soluble layer demonstrated slight functions in the results (Table 1). The resultant chloroform and butanol fractions were repeatedly subjected to silica gel and reverse phase column chromatographies and yielded two new compounds, viscolin (1) and (2S)-7,4Ј-dihydroxy-5,3Ј-dimethoxyflavanone (2).Viscolin (1) was a pale yellow needles, and its chemical formula, C 19 H 24 O 6 , was gained by HR-EI-MS (high resolution electron impact mass). UV spectrum of viscolin (1) revealed the maximum absorption at 282 and 229 (sh) nm and the absorption band at 3393 cm Ϫ1 showed hydroxyl group in its IR spectrum.In the 1 H-NMR spectrum (Table 2) of viscolin (1), four methoxyl signals appeared at d 3.88, 3.85, 3.82 and 3.74, respectively. In the aromatic region, an ABX splitting pattern and one singlet signals showed at d 6.83, 6.72, 6.70 and 6.31 indicated a tri-substituted and a penta-substituted phenyl moieties in 1. In addition, there were three mutual coupled methylene signals showed at d 2.62, 2.60 and 1.79 confirmed One new 1,3-diphenylpropane, viscolin (1), and one new flavanone, (2S)-7,4-dihydroxy-5,3-dimethoxyflavanone (2), together with thirty-nine known compounds, which included eleven known flavanones, two chromones, fourteen benzenoids, one inositol, two pyrimidines, four triterpenoids and five steroids...

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Triterpenoids of Paeonia japonica callus tissue

Cited by 111 publications

References 6 publications

Chemical and biological investigations of Dillenia indica Linn.

Chemical and biological investigations of Dillenia indica Linn.

Human ACAT-1 and ACAT-2 Inhibitory Activities of Pentacyclic Triterpenes from the Leaves of Lycopus lucidus TURCZ.

The Inhibition of Superoxide Anion Generation in Human Neutrophils by Viscum coloratum

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