Triton-B Catalyzed One Pot Multicomponent Synthesis of Isothiocyanates in Non-Aqueous Medium

Abstract

A facile and novel method to synthesize isothiocyanides from cyclic and acyclic amines and carbon disulphide in DMSO with Triton-B as catalyst in non-aqueous medium is being reported. The method is less tedious and offers excellent yields. The structures have been elucidated by 1 H NMR, 13 C NMR and mass spectroscopy.

Recent advancement in the synthesis of isothiocyanates

“…Numerous methods using CS 2 have been reported to overcome these limitations. 55–75 Several methods have been explored to broaden the substrate scope of electron-deficient anilines and aminopyridines. 55,57–61,67,71,72,74,75 Moreover, employing a strong base, 69 ball milling, 56 a photoredox catalyst, 72 an electrolytic reaction, 73 or an appropriate desulfurization reagent 60,61,68,71 enables the one-step synthesis of isothiocyanates.…”