Trophic-Level Interactive Effects of Phosphorus Availability on the Toxicities of Cadmium, Arsenic, and Their Binary Mixture in Media-Exposed <i>Scenedesmus acutus</i> and Media and Dietary-Exposed <i>Daphnia pulex</i>

Awoyemi, Olushola M.; Subbiah, Seenivasan; Thompson, Kelsey N.; Velazquez, Anahi; Peace, Angela; Mayer, Gregory D.

doi:10.1021/acs.est.9b07657

Cited by 13 publications

(4 citation statements)

References 78 publications

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“…For the design of mixture rays, as mentioned above, many scholars have been inclined to design in a single way. − In this study, we used EquRay to design three binary mixture systems. The results show that the 15 mixture rays of the three systems show different toxicological interactions.…”

Section: Resultsmentioning

confidence: 99%

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Study on the Combined Toxicities and Quantitative Characterization of Toxicity Sensitivities of Three Flavor Chemicals and Their Mixtures to Caenorhabditis elegans

et al. 2021

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It was shown that flavor chemicals with high toxicity sensitivities mean that small changes in their effective concentrations can lead to significant changes in toxicity. Flavors are widely used in personal care products. However, our study demonstrated that some flavor chemicals and their mixture rays have high toxicity sensitivities to Caenorhabditis elegans ( C. elegans ), which may have an impact on human health. In this paper, three flavor chemicals (benzyl alcohol, phenethyl alcohol, and cinnamaldehyde) were used as components of the mixture, and three binary mixture systems were constructed, respectively. Five mixture rays were designed for each mixture system by a direct equipartition ray design method. The lethal toxicities of the three flavor chemicals and mixture rays to C. elegans at three exposure volumes were determined. A new concept (inverse of the negative logarithmic concentration span (iSPAN)) was introduced to quantitatively evaluate the toxicity sensitivity of chemicals or mixture rays, and the combination index (CI) was employed to identify the toxicological interactions in the mixtures. It was shown that the three flavor chemicals as well as the binary mixture rays have a significant concentration–response relationship on the lethality of C. elegans . The iSPAN values of the three flavor chemicals and their mixture rays were larger than 3.000, showing very strong toxicity sensitivity to C. elegans . In mixture systems, the toxicity sensitivities of mixture rays with different mixture ratios were also different at different exposure volumes. In addition, it can be seen from the CI heat map that the toxicological interaction not only shows the mixture ratio dependence but also changes with the different exposure volumes, which implies that the mixtures consisting of flavor chemicals with high toxicity sensitivity have complex toxicological interactions. Therefore, in environmental risk assessment, special attention should be paid to chemicals with high toxicity sensitivities.

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Section: Resultsmentioning

confidence: 99%

“…The equivalent-effect concentration ratio (EECR), specified proportion, − and fixed proportion − are commonly used by most of the scholars when designing mixtures. For example, Zhao et al .…”

Section: Introductionmentioning

confidence: 99%

Study on the Combined Toxicities and Quantitative Characterization of Toxicity Sensitivities of Three Flavor Chemicals and Their Mixtures to Caenorhabditis elegans

et al. 2021

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“…Daphnia reared in LP can also increase the somatic concentrations of trace metals such as selenium and zinc (Browning et al, 2017;Guimarães et al, 2023;Wang et al, 2022), both of which have been shown to reduce As toxicity by increasing As methylation efficiencies, decreasing DNA damage and increasing metallothionein levels, respectively (Cooper et al, 2013;Zhao et al, 2019;Zwolak, 2020). Previous studies on the As-P interactions in Daphnia showed mixed results, with both negative (Miao et al, 2012) and positive interaction effects (Awoyemi et al, 2020;see Zhang et al, 2022). Another factor to consider when comparing As-P effects is the source of the As supply.…”

Section: Discussionmentioning

confidence: 99%

Differential Toxicity of Arsenic in Daphnia pulex Under Phosphorus and Food Limitation

Schultz,

Owens,

Demidenko

et al. 2024

Enviro Toxic and Chemistry

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The on‐going anthropogenic degradation of freshwater habitats has drastically altered the environmental supply of both nutrients and common pollutants. Most organisms living in these altered habitats experience interactive effects of various stressors that can initiate adjustments at multiple levels impacting their fitness. Hence, studies measuring response to a single environmental parameter fail to capture the complexities of the status quo. We tested both the individual and the interactive effect of arsenic (As) exposure, food quantity, and dietary phosphorus (P)‐supply on six life‐history traits (Juvenile Growth Rate; Adult Growth Rate; Age and Size at Maturity, Lifespan, and Fecundity) as surrogates for organismal fitness in the keystone aquatic grazer Daphnia pulex. We also tested the effect of food quantity and P‐supply on somatic As accumulation in Daphnia. Our results indicated an influence of P‐supply on neonatal growth and an influence of As and food quantity on growth and maintenance later in life. Maturation was strongly influenced by all three variables, with no reproduction observed in the presence of two or more environmental stressors. We found a strong interaction between As and dietary P, with increased P‐supply intensifing the toxicity effect of As. No such effects were seen between As and food quantity, indicating a differential role of quantity versus quality on As toxicity. We found a nominal effect of diet on somatic As accumulation. The results from the present study emphasize the importance of considering such interactions between co‐occurring environmental stressors and the dietary status of organisms, to better predict and manage impacts and risks associated with common environmental toxicants in highly vulnerable ecosystems. Environ Toxicol Chem 2024;00:1–13. © 2024 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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“…Daphnia pulex was acquired from Carolina Biological Supply Company (Burlington, NC, USA) and maintained as previously described [21]. Briefly, organisms were maintained in COMBO medium in a controlled Precision Low Temp BOD Refrigerated Incubator (VWR, Radnor, PN, USA).…”

Section: General Culture Methodsmentioning

confidence: 99%

Plant-Derived Products Selectively Suppress Growth of the Harmful Alga Prymnesium parvum

Mary,

Tábora-Sarmiento,

Nash

et al. 2024

Water

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Prymnesium parvum is a harmful alga found in brackish waters worldwide whose toxins can be lethal to aquatic organisms. Established field methods to control blooms of this species, however, are unavailable. Earlier studies showed that various extracts of giant reed (Arundo donax) can suppress P. parvum growth and that ellipticine, an allelochemical present in giant reed, is a potent algicide against this species. The unintended effects of giant reed products on nontarget organisms, however, are not fully understood. This study determined the effects of giant reed leachate (aqueous extract of dried chips) and ellipticine on growth of P. parvum and the green microalga Chlorella sorokiniana; survival and reproduction of the planktonic crustacean Daphnia pulex; and hatching success, larval survival, and larval swimming behavior of the teleost fish Danio rerio. Leachate made with 3 g chips L−1 was lethally toxic to P. parvum and D. pulex, stimulated C. sorokiniana growth, and impaired D. rerio behavior. Leachate at 1 g L−1 fully suppressed P. parvum growth, had moderate effects on D. pulex reproductive output, and had no effects on D. rerio. Ellipticine at 0.01 mg L−1 irreversibly inhibited P. parvum growth, acutely but reversibly inhibited C. sorokiniana growth, slightly delayed D. pulex reproduction, and had no effects on D. rerio. These observations suggest that when applied at appropriate concentrations, natural products derived from giant reed can be used as tools to specifically control P. parvum growth with minimal effects on nontarget species.

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Trophic-Level Interactive Effects of Phosphorus Availability on the Toxicities of Cadmium, Arsenic, and Their Binary Mixture in Media-Exposed Scenedesmus acutus and Media and Dietary-Exposed Daphnia pulex

Cited by 13 publications

References 78 publications

Study on the Combined Toxicities and Quantitative Characterization of Toxicity Sensitivities of Three Flavor Chemicals and Their Mixtures to Caenorhabditis elegans

Study on the Combined Toxicities and Quantitative Characterization of Toxicity Sensitivities of Three Flavor Chemicals and Their Mixtures to Caenorhabditis elegans

Differential Toxicity of Arsenic in Daphnia pulex Under Phosphorus and Food Limitation

Plant-Derived Products Selectively Suppress Growth of the Harmful Alga Prymnesium parvum

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