Trophoblasts and Soluble Adhesion Molecules in Peripheral Blood of Women with Pregnancy‐Induced Hypertension

Abstract

The increased number of trophoblast cells in maternal peripheral blood and higher levels of sVCAM-1 correlate with the presence of PIH. The differences of sVCAM levels were significantly higher than those observed for sICAM. The results indicate an association between circulating trophoblasts and vascular endothelium activation, during PIH.

Quantitative abnormalities of fetal trophoblast cells in maternal circulation in preeclampsia

“…Previous studies have shown that there was an increase of CFTCs in PE (Heimrath et al, 2004). We also found concordant results in that PE patients displayed higher number of CFTCs than control subjects.…”

“…As previously pointed out (Hahn and Holzgreve, 2002b), the placental lesions leading to the increased traffic of fetal cells into the maternal periphery occur early in those pregnancies which subsequently develop preeclampsia. Moreover, the vascular endothelium is activated during pregnancy-induced hypertension, and the amount of circulating trophoblasts is related to its activation status (Heimrath et al, 2004).…”

“…13 Hangkong Rd., 430030 Wuhan, Tel: 0086-27-83692651;Fax: 0086-27-83694480. E-mail: aihualiao@hotmail.com fetal cell traffic and the increased release of fetal DNA into maternal circulation of pregnant women affected by PE (Holzgreve et al, 1998;Holzgreve and Hahn, 1999;Lo et al, 1999;Al-Mufti et al, 2000;Jansen et al, 2001;Heimrath et al, 2004). Each of these cell types offers advantages.…”

The concentration of insulin-like growth factor-1 in pregnancies complicated by pregnancy-induced hypertension and/or intrauterine hypotrophy

“…This pathology can result in high resistance in placental vessels, significantly reducing placental blood flow. Impaired placental perfusion leads to fetal growth retardation, activation of inflammatory response cascade and damaging of endothelium [5,6].…”

Pregnancy-Induced Hypertension is Accompanied by Decreased Number of Circulating Endothelial Cells and Circulating Endothelial Progenitor Cells

“…Dysfunction of vascular endothelium in PIH women is accompanied by elevated amounts of syncytiotrophoblast particles and increased levels of several soluble adhesion molecules, e.g., sVCAM and sICAM, in peripheral blood (Heimrath et al 2004). Other studies have shown that concentration of serum vascular endothelial growth factor (VEGF), von Willebrand factor and fibronectin was also elevated.…”