Tropical fruits from Australia as potential treatments for metabolic syndrome

Panchal, Sunil K.; Brown, Lindsay

doi:10.1016/j.coph.2022.102182

Cited by 12 publications

(7 citation statements)

References 60 publications

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“…The supplementation with several dietary polyphenols has been shown to modify gut microbiota and thus alleviate NAFLD [ 8 , 9 ]. In particular, previous reports in animal studies revealed that litchi-derived products exerted beneficial functions by modulating the gut microbiota composition.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several approaches regarding the modification of the gut microbiota, to alleviate NAFLD and metabolic syndrome, were investigated in clinical and preclinical studies. In particular, the use of supplements of dietary natural products and functional foods have gained much attention, due to their health advantages with low toxicity profiles [ 8 , 9 ]. Among them, litchi ( Litchi chinensis Sonn.…”

Section: Introductionmentioning

confidence: 99%

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Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study

et al. 2022

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Preclinical data suggest the role of litchi extract in alleviating non-alcoholic fatty liver disease (NAFLD) by modulating gut microbiota. We aimed at investigating whether oligonol, a litchi-derived polyphenol, could improve liver steatosis and gut dysbiosis in patients with NAFLD. Adults with grade ≥2 steatosis, defined by an MRI proton density fat fraction (MRI-PDFF) of ≥11%, were randomly assigned to receive either oligonol or placebo for 24 weeks. The alteration in the MRI-PDFF and gut microbiota composition assessed by 16S ribosomal RNA sequencing were examined. There were 38 patients enrolled (n = 19 in each group). A significant reduction in the MRI-PDFF between week 0 and week 24 was observed in the oligonol group, while there was a non-significant decrease in the placebo group. A significant improvement in alpha-diversity was demonstrated in both of the groups. The oligonol-induced microbiota changes were characterized by reduced abundance of pathogenic bacteria, including Dorea, Romboutsia, Erysipelotrichaceae UCG-003 and Agathobacter, as well as increased abundance of short-chain fatty acids (SCFAs)-producing bacteria, such as Akkermansia, Lachnospira, Dialister and Faecalibacterium. In summary, this study is the first to provide evidence that supports that oligonol improves steatosis through the modulation of gut bacterial composition. Our results also support the beneficial and complementary role of oligonol in treating NAFLD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study

et al. 2022

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“…Specifically, QGP is comprised of primarily flavonoids, and specifically, flavonoid glycosides, which were found to be > 80% of the total polyphenol abundance across all four extraction solvents (Figure 6e). QGP has been recently investigated for its potential to reduce metabolic syndrome [30][31][32]56] and the results from the present study can provide insight into these applications. For example, the results from Figures 4-6 highlight the diversity, abundance, and ratio of flavonoid aglycones and glycosides in QGP.…”

Section: Untargeted Metabolomics Of Queen Garnet Plum Polyphenolsmentioning

confidence: 93%

Qualitative Analysis of Polyphenols in Glycerol Plant Extracts Using Untargeted Metabolomics

et al. 2023

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Glycerol is a reliable solvent for extracting polyphenols from food and waste products. There has been an increase in the application of glycerol over benchmark alcoholic solvents such as ethanol and methanol for natural product generation because of its non-toxic nature and high extraction efficiency. However, plant extracts containing a high glycerol concentration are unsuitable for mass spectrometry-based investigation utilising electrospray ionization, inhibiting the ability to analyse compounds of interest. In this investigation, a solid phase extraction protocol is outlined for removing glycerol from plant extracts containing a high concentration of glycerol and their subsequent analysis of polyphenols using ultra-performance liquid chromatography coupled with quadrupole time of flight tandem mass spectrometry. Using this method, glycerol-based extracts of Queen Garnet Plum (Prunus salicina) were investigated and compared to ethanolic extracts. Anthocyanins and flavonoids in high abundance were found in both glycerol and ethanol extracts. The polyphenol metabolome of Queen Garnet Plum was 53% polyphenol glycoside derivatives and 47% polyphenols in their aglycone forms. Furthermore, 56% of the flavonoid derivates were found to be flavonoid glycosides, and 44% were flavonoid aglycones. In addition, two flavonoid glycosides not previously found in Queen Garnet Plum were putatively identified: Quercetin-3-O-xyloside and Quercetin-3-O-rhamnoside.

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“…Bioactive compounds from Australian native foods, such as phenolic acids (gallic, m-, and tannin acids), flavonoids (quercetin, catechin, and rutin), anthocyanins, tocopherols, and ascorbic acid are linked to antioxidant activities and potent activities reducing inflammatory enzymes [35,50,56]. Plenty of Australian native foods are linked to antioxidant and anti-inflammatory activities, among them Carpobrotus rossii (pigface) [60], native peperberry [45], A. acidula (lemon aspen) [61], Mentha australis (Australian native mint) [62], green plum (Buchanania obovata) [44,59], Acacia seeds (A. cyclops, A. microbotrya and A. victoriae) [37,39,50], Davidson's plum (Davidsonia pruriens) [45,63], and Kakadu plum [35,51].…”

Section: Health Benefitsmentioning

confidence: 99%

Aboriginal Food Practices and Australian Native Plant-Based Foods: A Step toward Sustainable Food Systems

et al. 2023

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The current food system and food choices have resulted in the increased human use of natural resources such as water and soil, and have directly impacted the ‘Global Syndemic’—climate change, obesity, and undernutrition. Revitalising Indigenous food systems and incorporating native plant-based foods into current food systems may have the potential to reduce diet-linked chronic diseases and environmental degradation, and are important steps toward Indigenous rights and self-determination. This study aims to identify and describe Aboriginal food practices and Australian native plant-based foods and their social, environmental, and economic impacts on sustainable food systems. A scoping review was conducted using the five-stage framework informed by Arksey and O’Malley. To describe the results, the framework for sustainable food systems from the Food and Agriculture Organization of the United Nations—FAO was used. Articles were included if they described the impacts of Aboriginal food practices on sustainable food systems, were confined to studies that were conducted in the Australian context, and included native Australian plant-based foods. A total of 57 studies were identified that met the inclusion criteria. The major social impacts incorporated the nutritional and health benefits of Australian native plant-based foods, such as antidiabetic properties, anticancer and antioxidant activities, and cultural identification, involving Aboriginal ecological knowledge and their connection to their country. Within the environmental impacts category, studies showed that Australian native plant-based foods have environmental stress tolerance and some ecosystem benefits. The main economic impacts discussed in the literature were the source of income for remote communities and the potential market for Australian native plant-based foods. This review demonstrates that Aboriginal food practices and Australian native plant-based foods can contribute to more sustainable food systems and diets and give more voice and visibility to Aboriginal knowledge and aspirations. More research and investments are needed to face the challenges of including these foods in our current food systems.

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Tropical fruits from Australia as potential treatments for metabolic syndrome

Cited by 12 publications

References 60 publications

Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study

Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study

Qualitative Analysis of Polyphenols in Glycerol Plant Extracts Using Untargeted Metabolomics

Aboriginal Food Practices and Australian Native Plant-Based Foods: A Step toward Sustainable Food Systems

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