Tropisetron for Treating Established Postoperative Nausea and Vomiting

Abstract

Three hundred-fourteen patients suffering from postoperative nausea and vomiting received different i.v. doses of a new antiemetic drug, tropisetron, to determine the lowest effective dose. We found that a single i.v. administration of tropisetron significantly reduced postoperative nausea and vomiting after elective surgery with general anesthesia.

Treatment of established postoperative nausea and vomiting: a quantitative systematic review

“…In the 17 trials, which reported on the number of patients who were followed up before randomisation, 12,107 patients were followed up and 3,572 of those vomited or felt nauseous before treatment (average 30%, range 9% [32] to 63% [33]). We contacted the main authors of two trials to clarify inconsistencies in the reporting of late success data [34,35]. One author only responded to our enquiry [34]; these data were included in our analyses.…”

“…We contacted the main authors of two trials to clarify inconsistencies in the reporting of late success data [34,35]. One author only responded to our enquiry [34]; these data were included in our analyses.…”

“…Granisetron 0.1 mg, 1 mg, and 3 mg (386 patients received granisetron) and tropisetron 0.5 mg, 2 mg, and 5 mg (237) were tested in one multicentre trial each [34,41]. Dolasetron 12.5, 25 mg, 50 mg, and 100 mg was tested in two multicentre trials (765) [19,40].…”

“…Three trials only reported on anti-nausea efficacy; two multicentre trials on granisetron [41] and tropisetron [34], respectively, and one small trial on ondansetron [44] (Table 2). Anti-nausea efficacy was consistently less pronounced, compared with the anti-vomiting efficacy (Table 3, Figure 2).…”