2024
DOI: 10.1038/s41598-024-57185-w
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Troponin T is elevated in a relevant proportion of patients with 5q-associated spinal muscular atrophy

Hanna Sophie Lapp,
Maren Freigang,
Johannes Friese
et al.

Abstract: Troponin T concentration (TNT) is commonly considered a marker of myocardial damage. However, elevated concentrations have been demonstrated in numerous neuromuscular disorders, pointing to the skeletal muscle as a possible extracardiac origin. The aim of this study was to determine disease-related changes of TNT in 5q-associated spinal muscular atrophy (SMA) and to screen for its biomarker potential in SMA. We therefore included 48 pediatric and 45 adult SMA patients in this retrospective cross-sequential obs… Show more

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