2010
DOI: 10.1016/j.cell.2010.03.013
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TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation

Abstract: Summary A plethora of growth factors regulate keratinocyte proliferation and differentiation that control hair morphogenesis and skin barrier formation. Wavy hair phenotypes in mice result from naturally occurring loss-of-function mutations in the genes for TGF-α and EGFR. Conversely, excessive activities of TGF-α/EGFR result in hairless phenotypes and skin cancers. Unexpectedly, we found that mice lacking the TRPV3 gene also exhibit wavy hair coat and curly whiskers. Here we show that keratinocyte TRPV3, a me… Show more

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Cited by 272 publications
(334 citation statements)
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“…Although skin barrier integrity has not been measured in Olmsted syndrome patients, embryonic day 17 TRPV3-null mouse embryos show significant dye permeability compared with control embryos, indicating a defect in barrier integrity in the absence of TRPV3 in the mouse (Cheng et al, 2010). Also in mice, TRPV3 has been shown to regulate epidermal growth factor receptor (EGFR) signalling as well as the activity of transglutaminases, enzymes that crosslink proteins during the formation of the cornified envelope (Cheng et al, 2010). The EGFR signalling pathway is important for the balance between keratinocyte proliferation and differentiation (Schneider et al, 2008) and, in TRPV3-null mouse skin, the level of EGFR activity is reduced (Cheng et al, 2010).…”
Section: Trpv Channelsmentioning
confidence: 98%
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“…Although skin barrier integrity has not been measured in Olmsted syndrome patients, embryonic day 17 TRPV3-null mouse embryos show significant dye permeability compared with control embryos, indicating a defect in barrier integrity in the absence of TRPV3 in the mouse (Cheng et al, 2010). Also in mice, TRPV3 has been shown to regulate epidermal growth factor receptor (EGFR) signalling as well as the activity of transglutaminases, enzymes that crosslink proteins during the formation of the cornified envelope (Cheng et al, 2010). The EGFR signalling pathway is important for the balance between keratinocyte proliferation and differentiation (Schneider et al, 2008) and, in TRPV3-null mouse skin, the level of EGFR activity is reduced (Cheng et al, 2010).…”
Section: Trpv Channelsmentioning
confidence: 98%
“…These gainof-function mutations in TRPV3 result in increased levels of keratinocyte apoptosis, leading to the formation of hyperkeratotic plaques (Lin et al, 2012). Although skin barrier integrity has not been measured in Olmsted syndrome patients, embryonic day 17 TRPV3-null mouse embryos show significant dye permeability compared with control embryos, indicating a defect in barrier integrity in the absence of TRPV3 in the mouse (Cheng et al, 2010). Also in mice, TRPV3 has been shown to regulate epidermal growth factor receptor (EGFR) signalling as well as the activity of transglutaminases, enzymes that crosslink proteins during the formation of the cornified envelope (Cheng et al, 2010).…”
Section: Trpv Channelsmentioning
confidence: 99%
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