2024
DOI: 10.3390/s24216923
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TRPV4—A Multifunctional Cellular Sensor Protein with Therapeutic Potential

Sanna Koskimäki,
Sari Tojkander

Abstract: Transient receptor potential vanilloid (TRPV) channel proteins belong to the superfamily of TRP proteins that form cationic channels in the animal cell membranes. These proteins have various subtype-specific functions, serving, for example, as sensors for pain, pressure, pH, and mechanical extracellular stimuli. The sensing of extracellular cues by TRPV4 triggers Ca2+-influx through the channel, subsequently coordinating numerous intracellular signaling cascades in a spatio-temporal manner. As TRPV channels pl… Show more

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