True or false? Challenges and recent highlights in the development of aspirin prodrugs

Willetts, Steffan; Foley, David W.

doi:10.1016/j.ejmech.2020.112200

Cited by 17 publications

(5 citation statements)

References 74 publications

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“…Furthermore, Liu et al found that arecoline can promote osteoblast differentiation and inhibit osteoclastogenesis [ 93 ]. Considering that osteoporosis and cardiovascular disease are common side effects caused by long-term aspirin treatment for inflammation [ 163 ], areca nut extracts are set to be developed into better drugs to treat inflammation and avoid or reduce side effects.…”

Section: Functional Effects Of Areca Nut Componentsmentioning

confidence: 99%

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Sun,

Yu,

et al. 2024

Nutrients

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Areca catechu L. is a widely cultivated tropical crop in Southeast Asia, and its fruit, areca nut, has been consumed as a traditional Chinese medicinal material for more than 10,000 years, although it has recently attracted widespread attention due to potential hazards. Areca nut holds a significant position in traditional medicine in many areas and ranks first among the four southern medicines in China. Numerous bioactive compounds have been identified in areca nuts, including alkaloids, polyphenols, polysaccharides, and fatty acids, which exhibit diverse bioactive functions, such as anti-bacterial, deworming, anti-viral, anti-oxidant, anti-inflammatory, and anti-tumor effects. Furthermore, they also display beneficial impacts targeting the nervous, digestive, and endocrine systems. This review summarizes the pharmacological functions and underlying mechanisms of the bioactive ingredients in areca nut. This helps to ascertain the beneficial components of areca nut, discover its medicinal potential, and guide the utilization of the areca nut.

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Section: Functional Effects Of Areca Nut Componentsmentioning

confidence: 99%

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Sun,

Yu,

et al. 2024

Nutrients

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“…It has been a feature of about 1 in 20 drugs currently available on the legal market, with increasing number of prodrugs (1 in 8) in more recent years (Rautio et al, 2008; Rautio et al, 2018). Aspirin was thought to be a prodrug needing conversion to salicylate to be effective (Willetts & Foley, 2020; Wu, 2000). It was later discovered that acetylsalicylic acid itself is effective in disrupting prostaglandin synthesis (Willetts & Foley, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Aspirin was thought to be a prodrug needing conversion to salicylate to be effective (Willetts & Foley, 2020; Wu, 2000). It was later discovered that acetylsalicylic acid itself is effective in disrupting prostaglandin synthesis (Willetts & Foley, 2020). There is now considerable research into finding a true aspirin prodrug, which may reduce the known gastric effects of aspirin (Gaisina et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

The use of prodrugs as drugs of abuse

Ponce

2024

WIREs Forensic Science

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Prodrugs are an important strategy for the development and design of therapeutic drugs. They involve the addition of an easily removable group (such as an ester) to a molecule in order to chemically protect it from metabolism, hydrolysis, or interaction with tissues. In the therapeutic drug market, prodrugs may reduce adverse effects, lead to more accurate tissue delivery, increase bioavailability and duration of effects. The same strategy has, however, been used in the illicit drug market. Internationally controlled drugs such as LSD, MDMA and benzodiazepines have been detected in the market with the addition of alkyl chain that can be removed in physiological conditions. Cyclical analogues may also be used, as is the case for 1cP‐LSD and GBL (a prodrug of GHB). Adequate detection requires increased care with extraction and analytical conditions—as the parent drugs may be formed as artifacts during these processes—and an in‐depth knowledge of metabolic pathways to avoid erroneous detection and allow for adequate identification of the drug used. Legislative updates may also be necessary to ensure prodrugs can be controlled at the same level as other illicit drugs.This article is categorized under: Toxicology > New Psychoactive Substances Toxicology > Drug Analysis Toxicology > Analytical

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“…This is why many researchers adopted investigation of aspirin based-analogues as potential antitumor candidates [36] , [37] , [38] , [39] . Others considered conjugation of aspirin with antitumor chemotherapeutics [40] because inflammation initiated by cancer may lead to metastasis [41] . Furthermore, the reported antitumor properties of salicylamide-containing compounds [42] , [43] , [44] prompted the current study due to the targeted salicylamide derivative formed through conjugation of the carboxylic group of aspirin with the nitrogen atom of piperidinyl heterocycle.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of aspirin-curcumin mimic conjugates of potential antitumor and anti-SARS-CoV-2 properties

Srour

Panda

Mostafa

et al. 2021

Bioorganic Chemistry

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True or false? Challenges and recent highlights in the development of aspirin prodrugs

Cited by 17 publications

References 74 publications

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

The use of prodrugs as drugs of abuse

Synthesis of aspirin-curcumin mimic conjugates of potential antitumor and anti-SARS-CoV-2 properties

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