Trust Your Gut: The Association of Gut Microbiota and Liver Disease

Manzoor, Ridda; Ahmed, Weshah; Afify, Nariman; Memon, Mashal; Yasin, Maryam; Memon, Hamda; Rustom, Mohammad; Akeel, Mohannad Al; Alhajri, Noora

doi:10.3390/microorganisms10051045

Cited by 27 publications

(26 citation statements)

References 159 publications

(232 reference statements)

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“…Intestinal microbiome disorders may also affect the progression of liver fibrosis. In patients with chronic liver disease, bacteria and their products are often transported across the intestinal barrier that has been disrupted [ 171 ]. Blocking Toll-like receptor 4 (TLR4) signaling in mice and reducing liver exposure to intestinal microbes by using antibiotics decelerate the development of liver fibrosis [ 172 ].…”

Section: Fibrotic Diseases: Pathogenesis and Mechanismmentioning

confidence: 99%

Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

Qin

Liu

Bao³

et al. 2022

Acta Pharmacol Sin

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Section: Fibrotic Diseases: Pathogenesis and Mechanismmentioning

confidence: 99%

Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

Qin

Liu

Bao³

et al. 2022

Acta Pharmacol Sin

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“…Hepatitis B virus (HBV) infection, Hepatitis C virus (HCV) infection, alcohol abuse and nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic hepatitis and HCC worldwide (17, 18). Some studies have found that the gut microbiota has significant influence in the development of liver cirrhosis, liver ischemic injury, NAFLD, HCC, and liver graft rejection (19)(20)(21)(22). Additionally, the gut microbiotas of HCC patients are significantly different from those of normal subjects, and changes in the composition of gut microbiotas could reveal to grade severity or progression of illness in HCC (23,24).…”

Section: Discussionmentioning

confidence: 99%

Association between gut microbiota and hepatocellular carcinoma from 2011 to 2022: Bibliometric analysis and global trends

Chen

Ding

et al. 2023

Front. Oncol.

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BackgroundHepatocellular carcinoma (HCC) is a primary malignant tumor responsible for approximately 90% of all liver cancers in humans, making it one of the leading public health problems worldwide. The gut microbiota is a complex microbial ecosystem that can influence tumor formation, metastasis, and resistance to treatment. Therefore, understanding the potential mechanisms of gut microbiota pathogenesis is critical for the prevention and treatment of HCC.Materials and methodsA search was conducted in the Web of Science Core Collection (WoSCC) database for English literature studies on the relationship between gut microbiota and HCC from 2011 to 2022. Bibliometric analysis tools such as VOSviewer, CiteSpace, and R Studio were used to analyze global trends and research hotspots in this field.ResultsA total of 739 eligible publications, comprising of 383 articles and 356 reviews, were analyzed. Over the past 11 years, there has been a rapid increase in the annual number of publications and average citation levels, especially in the last five years. The majority of published articles on this topic originated from China (n=257, 34.78%), followed by the United States of America (n=203, 27.47%), and Italy (n=85, 11.50%). American scholars demonstrated high productivity, prominence, and academic environment influence in the research of this subject. Furthermore, the University of California, San Diego published the most papers (n=24) and had the highest average citation value (value=152.17) in the study of the relationship between gut microbiota and HCC. Schnabl B from the USA and Ohtani N from Japan were the authors with the highest number of publications and average citation value, respectively.ConclusionIn recent years, research on the gut microbiota’s role in HCC has made rapid progress. Through a review of published literature, it has been found that the gut microbiota is crucial in the pathogenesis of HCC and in oncotherapy.

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“…These include steatosis, inflammation, and liver damage. Liver disorders such as primary cholangitis or spotted liver disease in poultry farming can be caused by both qualitative and quantitative changes in the gut microbiota [ 72 , 73 ]. A healthy liver is a barrier between systemic circulation and the intestines.…”

Section: Gut-liver Axismentioning

confidence: 99%

State of the art in research on the gut-liver and gut-brain axis in poultry

Bełdowska

Barszcz

Dunisławska

2023

J Animal Sci Biotechnol

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The relationship between the intestines and their microbiota, the liver, and the neuronal system is called the gut-liver-brain axis. This relationship has been studied and observed for a relatively short time but is considered in the development of research focused on, e.g., liver diseases and intestinal dysbiosis. The role of the gut microbiota in this relationship is crucial, as it acts on poultry’s performance and feed utilization, affecting meat and egg quality. The correct composition of the intestinal microbiota makes it possible to determine the essential metabolic pathways and biological processes of the individual components of the microbiota, allowing further speculation of the role of microbial populations on internal organs such as the liver and brain in the organism. The gut microbiota forms a complex, dense axis with the autonomic and enteric nervous systems. The symbiotic relationship between the liver and gut microbiota is based on immune, metabolic and neuroendocrine regulation, and stabilization. On the other hand, the gut-brain axis is a bidirectional interaction and information transfer system between the gastrointestinal tract and the central nervous system. The following paper will discuss the current state of knowledge of the gut-liver-brain axis of poultry, including factors that may affect this complex relationship.

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Trust Your Gut: The Association of Gut Microbiota and Liver Disease

Cited by 27 publications

References 159 publications

Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

Association between gut microbiota and hepatocellular carcinoma from 2011 to 2022: Bibliometric analysis and global trends

State of the art in research on the gut-liver and gut-brain axis in poultry

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