Trypanocidal activity of the essential oils in their conventional and nanoemulsion forms: In vitro tests

Baldissera, Matheus D.; Silva, Aleksandro S. Da; Oliveira, Camila Belmonte; Zimmermann, Carine Eloise Prestes; Vaucher, Rodrigo de Almeida; Santos, Roberto C.V.; Rech, Virgínia Cielo; Tonin, Alexandre A.; Giongo, Janice Luehring; Mattos, Cristiane Bastos de; Koester, Letícia Scherer; Santúrio, Jânio Morais; Monteiro, Sílvia González

doi:10.1016/j.exppara.2013.03.035

Cited by 62 publications

(36 citation statements)

References 25 publications

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Section: Pitmentioning

confidence: 67%

“…After the experiment had been going on for 3 and 6 hours, all microorganisms were dead. The results demonstrate that these oils can be more effective against T. evansi, when prepared as NE (Baldissera et al, 2013).The cytotoxic potential in vitro of NE containing casca-de-anta (Drimys angustifolia Miers and Drimys brasiliensis Miers) was evaluated on human glioblastoma (U-138 MG) and bladder carcinoma (T24) cell lines NE of VO from two species using the tetrazolium salt 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazoliumThe use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications 353 bromide (MTT) method. Opalescent bluish NE, with droplet diameters of 168 nm (D.angustifolia) and 181 nm (D. brasiliensis) were obtained.…”

mentioning

confidence: 69%

“…In vitro antiparasitic activity (Baldissera et al, 2013) Anise (25, 50 and 75% of oil phase) Soy lecithin (5%) HPH In vitro antimicrobial activities (Topuz et al, 2016) Argan Polyethoxylated solutol HS-15 EPI In vitro cytotoxic activity (Jordan et al, 2012) Babassu (5%) Mixture of sorbitan monooleate and PEG-54 castor oil (10%) PIT Pharmaceutical and cosmetic matrices (Gumiero, Filho,2012) Carqueja-doce (3.32%) Polysorbate (0.77%) SE In vitro antifungal activity (Danielli et al, 2013) Casca-de-anta (4%) Polysorbate 20 (1%) Sorbitan monooleate (1%) HPH In vitro cytotoxic activity (Gomes et al, 2013) Cinnamon (6%) Polysorbate 80 (18%) EPI In vitro antibacterial activity (Nirmala et al, 2013) Cinnamon bark (1%)…”

Section: Hphmentioning

confidence: 99%

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The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Bajerski

Michels

Colomé

et al. 2016

Braz. J. Pharm. Sci.

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Vegetable oils present important pharmacological properties, which gained ground in the pharmaceutical field. Its encapsulation in nanoemulsions is considered a promising strategy to facilitate the applicability of these natural compounds and to potentiate the actions. These formulations offer several advantages for topical and systemic delivery of cosmetic and pharmaceutical agents including controlled droplet size, protection of the vegetable oil to photo, thermal and volatilization instability and ability to dissolve and stabilize lipophilic drugs. For these reasons, the aim of this review is to report on some characteristics, preparation methods, applications and especially analyze recent research available in the literature concerning the use of vegetable oils with therapeutic characteristics as lipid core in nanoemulsions, specially from Brazilian flora, such as babassu (Orbignya oleifera), aroeira (Schinus molle L.), andiroba (Carapa guaianiensis), casca-de-anta (Drimys brasiliensis Miers), sucupira (Pterodon emarginatus Vogel) and carqueja doce (Stenachaenium megapotamicum) oils.Uniterms: Plant oils/nanoemulsions/preparation. Plant oils/biological applications. INTRODUCTIONThe use of submicrometric colloidal nanocarriers such as nanoparticles (NP) lipid and polymeric, nanoemulsions (NE), microemulsions (ME), liposomes, and polymeric micelles is considered a promising system in the pharmaceutical field, because they have numerous advantages over traditional formulations such as: sustained release of the active element; solubilization of lipophilic molecules; use for different routes of administration; protection from chemical and enzymatic degradation of labile molecules; reduction of vegetable oils (VO) volatilization, side effects and dose (Mäder, Mehnert, 2005;Mehnert, Mäder, 2001;Gref, Couvreour, 2006;Couvreur, Vauthier, 2006; Panyam, Labhasetwar, 2003;Soppimath et al., 2001;Ai et al., 2011; Contri et al., 2012;Contri et al., 2014;Dimer et al., 2014;Severino et al., 2015;Frank et al., 2015;Asbahani et al., 2015). However, all systems differ thermodynamic stability, structure, chemical composition, efficiency encapsulation and types of application (Mäder, Mehnert, 2005;Ai et al., 2011).The development of suitable nanocarriers for pharmaceutical or cosmetic application requires the adequate selection of their adjuvants such as polymers for nanocapsules (NC), surfactants, and oils (Schaffazick et al., 2003;Alvarez-Román et al., 2001;Bouchemal et al., 2004;Friedrich et al., 2008). Recently, special attention has been given to the type of oily phase used as the core in the preparation of NE. VO has been preferred not only due to the concept that it is safe and biocompatible, but mainly because of the diversity of benefits, and the complex composition of fatty acids can exercise under the skin, protecting it against dehydration, solar radiation, inflammation, insect attack, microorganisms, and viruses (Tadros, Kessell, 2004;Bloise, 2003;Oyedeji, Okeke, 2010;Bakkali et. al., 2008;Harris, 2002; Contri et al, ...

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Section: Pitmentioning

confidence: 67%

mentioning

confidence: 69%

Section: Hphmentioning

confidence: 99%

See 1 more Smart Citation

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Bajerski

Michels

Colomé

et al. 2016

Braz. J. Pharm. Sci.

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“…For each sample, six readings with three replicates were done on the Zetasizer (7,15,30,60,90, and 120 days), and the parameters of the polydispersity index (PDI), zeta potential, and hydrodynamic diameter (Hd) were obtained.…”

Section: Characterization Of the Nanoemulsion (Dls/zeta)mentioning

confidence: 99%

“…In the current scientific literature, to our knowledge, there are only three studies that refer to the development of nanoformulations with andiroba oil [13][14][15]. Other plant oils with therapeutic properties have been incorporated in nanomaterials, but few have been studied for their biocompatibility and toxicity [9,14,16].…”

mentioning

confidence: 99%

Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

Milhomem-Paixão

Fascineli

Muehlmann

et al. 2017

Journal of Nanomaterials

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Andiroba oil (AO) is obtained from an Amazonian plant and is used in traditional medicine. We carried out a comparative study to test the cytotoxicity, genotoxicity, and hematotoxicity of the oil and its nanoemulsion (AN) in vitro (fibroblasts, lineage NIH/3T3) and in vivo (Swiss mice). The AN was characterized by DLS/Zeta, and its stability was investigated for 120 days. The biological activity of AN was assessed in vitro by MTT test and cell morphology analyses and in vivo by micronucleus, comet, and hematotoxicity tests. The AN presented a hydrodynamic diameter (Hd) of 142.5 ± 3.0 and PDI of 0.272 ± 0.007 and good stability at room temperature. The MTT test evidenced the cytotoxicity of AO and of AN only at their highest concentrations, but AN showed lower cytotoxicity than AO. A lower cytotoxicity of AN, when compared to AO, is in fact an interesting data suggesting that during therapeutic application there will be a lower impact in the cell viability of healthy cells. Cytotoxicity, genotoxicity, and hematotoxicity were not observed in vivo. These tests on the biological and toxicological effects of andiroba oil and nanostructured oil are still initial ones but will give a direction to future application in cosmetics and/or the development of new phytotherapics.

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Microbial biosurfactant based nanoemulsions and their applications: A review

Yoosuf,

Nambiar

2023

J Surfact & Detergents

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Nanoemulsions exhibit a wide range of practical applications owing to their smaller particle size, stability, and enhanced bioavailability. Conventional surfactants widely used in nanoemulsion formulations namely, polysorbate 80, macrogolglycerol ricinoleate, and 4‐octylphenol polyethoxylate have been associated with anaphylactoid responses, alterations in normal flora, cytotoxicity and tissue damage. The use of less toxic, environment‐friendly microbial biosurfactants in the formulation of nanoemulsions have been demonstrated to manifest stability, slow drug release, enhanced skin permeability, and bioactivity. The type and composition of mixed microbial biosurfactants used in nanoemulsions can decrease the droplet size and synergistically increase the stability. Moreover, a lower concentration of drug‐loaded surfactin‐based nanoemulsion synergistically inhibited the proliferation of cancer cells by 50% (IC50). The scope of the current review is to focus on the prospect of substituting conventional surfactants with biosurfactants obtained from microbial origin for nanoemulsion formulations. It also aims to draw attention to the paucity of research in the combinatorial study of biosurfactants and functional drugs used in nanoemulsions. The review emphasizes the bioactivity of microbial biosurfactant‐based nanoemulsions and their applications in diverse sectors. The differences in emulsion stability and size of microbial biosurfactant and conventional surfactant‐based nanoemulsions have been highlighted. The study intends to promote comparative research between nanoemulsions prepared using conventional surfactants and microbial biosurfactants.

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Trypanocidal activity of the essential oils in their conventional and nanoemulsion forms: In vitro tests

Cited by 62 publications

References 25 publications

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

Microbial biosurfactant based nanoemulsions and their applications: A review

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