2022
DOI: 10.3389/fcimb.2022.760830
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Trypanosoma cruzi Genomic Variability: Array Comparative Genomic Hybridization Analysis of Clone and Parental Strain

Abstract: Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits extensive inter- and intrastrain genetic diversity. As we have previously described, there are some genetic differences between the parental G strain and its clone D11, which was isolated by the limiting dilution method and infection of cultured mammalian cells. Electrophoretic karyotyping and Southern blot hybridization of chromosomal bands with specific markers revealed chromosome length polymorphisms of small size with additional chromosom… Show more

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“…This variability may play a crucial role in adaptive environmental responses. Then, it is essential to understand how these genetic differences manifest in specific phenotypic characteristics, such as virulence, replication rates, tissue tropisms, metacyclogenesis potential, parasitemia curves in animal models, and treatment resistance (Berná et al 2018 ; Cortez et al 2022 ).…”
Section: Introductionmentioning
confidence: 99%
“…This variability may play a crucial role in adaptive environmental responses. Then, it is essential to understand how these genetic differences manifest in specific phenotypic characteristics, such as virulence, replication rates, tissue tropisms, metacyclogenesis potential, parasitemia curves in animal models, and treatment resistance (Berná et al 2018 ; Cortez et al 2022 ).…”
Section: Introductionmentioning
confidence: 99%