Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells

Iwaki, Kanso; Ohashi, Emiko; Arai, Norie; Kohno, Keizo; Ushio, Shimpei; Taniguchi, Makoto; Fukuda, Shigeharu

doi:10.1016/j.jep.2010.12.041

Cited by 35 publications

(23 citation statements)

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“…Allergic diseases are initiated by the development of allergen‐specific T‐helper type 2 (Th2) cells and amplified by the degranulation of and cytokine release from basophils and mast cells during an effector phase. In 2011, tryptanthrin was studied for its effects on the initiation and effector phase responses of Type I allergy in vitro . It suppressed c‐Maf mRNA expression in Th2 clone cells, inhibited IgE‐mediated degranulation, and IL‐4 production in RBL‐2H3 cells, and reduced differentiation toward the Th2 phenotype, which is a key step in allergic initiation.…”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

“…It suppressed c‐Maf mRNA expression in Th2 clone cells, inhibited IgE‐mediated degranulation, and IL‐4 production in RBL‐2H3 cells, and reduced differentiation toward the Th2 phenotype, which is a key step in allergic initiation. Thus, tryptanthrin effectively inhibited the effector and exacerbation responses, as well as the initiator responses, of Type I allergy . Then in 2016, tryptanthrin was investigated regarding its regulating effects on thymic stromal lymphopoietin (TSLP) induced mast cell proliferation and proinflammatory cytokine, TNF‐α production from mast cells .…”

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

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Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

158

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To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, hepatoprotective, antioxidant, anti-asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

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Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

Section: Biological Activities Of Quinoline and Quinazoline Alkaloidsmentioning

confidence: 99%

Biologically active quinoline and quinazoline alkaloids part II

Shang

Morris‐Natschke

Yang

et al. 2018

Medicinal Research Reviews

158

View full text Add to dashboard Cite

show abstract

“…In recent years, to ameliorate pathology after stroke, many researchers have tried to regulate microglia function and changes in microglia phenotype during inflammatory conditions using various substances (Song et al, 2014 ; Zhang et al, 2015 ; Shu et al, 2016 ). Tryptanthrin (6,12-dihydro-6,12-dioxoindolo-(2,1-b)-quinazoline) is a natural alkaloid found in P. tinctorium (Honda et al, 1980 ; Scovill et al, 2002 ), and has been reported to have various pharmacological effects, such as, anti-inflammatory (Recio et al, 2006 ; Iwaki et al, 2011 ), antimicrobial (Honda et al, 1979 ) and anti-tumor effects (Kimoto et al, 2001 ; Yu et al, 2007 , 2009 ; Liao et al, 2013 ). Tryptanthrin has also been reported to suppress NO and prostaglandin E synthesis in macrophages exposed to oxidative stress (Ishihara et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling

Kwon

Cheon

Park

et al. 2017

Front. Cell. Neurosci.

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Microglia are the resident macrophages in the central nervous system (CNS) and play essential roles in neuronal homeostasis and neuroinflammatory pathologies. Recently, microglia have been shown to contribute decisively to neuropathologic processes after ischemic stroke. Furthermore, natural compounds have been reported to attenuate inflammation and pathologies associated with neuroinflammation. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione) is a phytoalkaloid with known anti-inflammatory effects in cells. In present study, the authors confirmed middle cerebral artery occlusion (MCAO) injury triggers the activation of microglia in brain tissue, and investigated whether tryptanthrin influences the function of mouse murine BV2 microglia under LPS-induced inflammatory conditions in vitro. It was found tryptanthrin protected BV2 microglia cells against LPS-induced inflammation and inhibited the induction of M1 phenotype microglia under inflammatory conditions. In addition, tryptanthrin reduced the production of pro-inflammatory cytokines in BV2 microglia cells via nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) signaling and NF-κB signaling. The authors suggest that tryptanthrin might alleviate the progress of neuropathologies by controlling microglial functions under neuroinflammatory conditions.

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“…Its efficacy against allergy [87], intestinal disorders [88], and inflammatory bowel disease [89] has also been reported. More interestingly, the cytotoxic [57,69,[90][91], antitumor [92][93][94], and chemopreventive [95] potential of this indoloquinazoline alkaloid has also been illustrated by many researchers [96].…”

Section: Medicinal Valuementioning

confidence: 97%