TTV viral load as a predictor of antibody response to SARS COV-2 vaccination

Focosi, Daniele; Baj, Andreina; Azzi, Lorenzo; Novazzi, Federica; Maggi, Fabrizio

doi:10.1016/j.healun.2022.10.025

Cited by 6 publications

(8 citation statements)

References 13 publications

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“…Anelloviruses, and TTV in particular, are now considered potential surrogate markers of functional immunity in solid organ transplant recipients. Interestingly, recent reports found that high levels of TTV in the blood are predictive of a poor response to SARS‐CoV‐2 vaccination in lung and kidney transplant recipients 17–20 …”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, recent reports found that high levels of TTV in the blood are predictive of a poor response to SARS-CoV-2 vaccination in lung and kidney transplant recipients. [17][18][19][20] In this study, we observed that the TTV load in nasopharyngeal samples could predict the need for ICU admission in patients infected with SARS-CoV-2. We established a threshold value as an independent predictor.…”

Section: Discussionmentioning

confidence: 99%

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Respiratory torque teno virus load at emergency department visit predicts intensive care unit admission of SARS‐CoV‐2 infected patients

Feghoul,

Caillault,

Peyrony

et al. 2023

Journal of Medical Virology

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Accurate prediction of COVID‐19 severity remains a challenge. Torque teno virus (TTV), recognized as a surrogate marker of functional immunity in solid organ transplant recipients, holds the potential for assessing infection outcomes. We investigated whether quantifying TTV in nasopharyngeal samples upon emergency department (ED) admission could serve as an early predictor of COVID‐19 severity. Retrospective single‐center study in the ED of Saint‐Louis Hospital in Paris, France. TTV DNA was quantified in nasopharyngeal swab samples collected for SARS‐CoV‐2 testing. Among 295 SARS‐CoV‐2 infected patients, 92 returned home, 160 were admitted to medical wards, and 43 to the intensive care unit (ICU). Elevated TTV loads were observed in ICU patients (median: 3.02 log copies/mL, interquartile range [IQR]: 2.215–3.825), exceeding those in discharged (2.215, [0; 2.962]) or hospitalized patients (2.24, [0; 3.29]) (p = 0.006). Multivariate analysis identified diabetes, obesity, hepatitis, fever, dyspnea, oxygen requirement, and TTV load as predictors of ICU admission. A 2.91 log10 copies/mL TTV threshold independently predicted ICU admission. Nasopharyngeal TTV quantification in SARS‐CoV‐2 infected patients is linked to the likelihood of ICU admission and might reflect respiratory immunosuppression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Respiratory torque teno virus load at emergency department visit predicts intensive care unit admission of SARS‐CoV‐2 infected patients

Feghoul,

Caillault,

Peyrony

et al. 2023

Journal of Medical Virology

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“…According to research, the measure of TTV viremia may be helpful in determining the immunological state of those who have received solid organ transplants and in monitoring immunosuppression and risks of post-transplant complications ( Redondo et al., 2022 ; Fernández-Ruiz, 2020 ; Jaksch et al., 2022 ; Maggi et al., 2018 ; Giacconi et al., 2018 ). More recently, the predictive role of TTV load with regard to vaccine response anti-SARS-CoV-2 as well as a potential pharmacodynamic biomarker in patients with chronic arthritis treated with biologic DMARD has also been demonstrated, suggesting other intriguing applications for this widespread AV ( Martin-López et al., 2020 ; Studenic et al., 2022 ; Focosi et al., 2023 ).…”

Section: Clinical Featuresmentioning

confidence: 99%

TTV and other anelloviruses: The astonishingly wide spread of a viral infection

Spezia¹,

Focosi²,

Baj³

et al. 2023

Aspects of Molecular Medicine

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“…Available guidelines inform that it is better to vaccinate over a longer period of time after transplantation and rejection treatment, as the response to vaccination in the early period is low [ 32 ]. In this context, it seems that TTV may be a valuable marker in predicting the response to vaccination [ 33 ]. An analysis involving 103 lung transplant recipients, spanning from 4 to 237 months post transplantation and receiving mRNA vaccination against COVID-19, evaluated the humoral response to the vaccine.…”

Section: Role In the Prediction Of The Response To Vaccinationmentioning

confidence: 99%

Torque Teno Virus (TTV)—A Potential Marker of Immunocompetence in Solid Organ Recipients

Kuczaj,

Przybyłowski,

Hrapkowicz

2023

Viruses

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Torque Teno Virus (TTV), first discovered in 1997, is a non-pathogenic, highly prevalent virus with a notable presence in the human virome. TTV has garnered attention as a potential indicator of immunocompetence in recipients of solid organ transplants. In this review, we discuss the role of TTV as a potential marker for immunosuppression optimization, prediction of graft rejection, and as an indicator of opportunistic infections. We discuss TTV’s behavior over the course of time after transplantation, TTV’s implications in different immunosuppressive regimens, and potential utility in vaccinations. The review synthetizes findings from various studies depicting its potential clinical utility for future personalized patient care.

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TTV viral load as a predictor of antibody response to SARS COV-2 vaccination

Cited by 6 publications

References 13 publications

Respiratory torque teno virus load at emergency department visit predicts intensive care unit admission of SARS‐CoV‐2 infected patients

Respiratory torque teno virus load at emergency department visit predicts intensive care unit admission of SARS‐CoV‐2 infected patients

TTV and other anelloviruses: The astonishingly wide spread of a viral infection

Torque Teno Virus (TTV)—A Potential Marker of Immunocompetence in Solid Organ Recipients

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