Tu-P7:121 Soluble thrombomdulin (STM) — A molecular marker of endothelial cell injury in children and adolescents with type 1 diabetes

Wojtkielewicz, Katarzyna; Urban, Marcia; Kowaleski, Mariusz; Peczyńska, Jadwiga; Głowińska, Barbara

doi:10.1016/s1567-5688(06)80827-5

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such patients were not included in our study. There are also reports according to which patients with hypertension presented an increased TM concentration in comparison with normotensive controls (44). In this study, however, we revealed statistically lower activity of TM in the group with SCS than in the healthy controls, despite hypertension in 57% of the study participants.…”

Section: Discussioncontrasting

confidence: 75%

The estimation of selected endogenous anticoagulation system parameters in patients with subclinical Cushing's syndrome

Świątkowska−Stodulska

Kaniuka-Jakubowska²,

Wiśniewski³

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: An increased tendency towards thromboembolic events is observed in patients with Cushing's syndrome. There are much fewer publications available about thromboembolic complications in patients with subclinical Cushing's syndrome (SCS). Therefore, a question arises whether hemostatic disturbances appear in this particular disease phase. Aim of study: Estimation of protein C (PC), free protein S (FPS), antithrombin (AT) activity, thrombomodulin (TM) concentration and activated PC resistance (APCR) in patients with SCS. Materials and methods: We studied 35 patients with SCS. The control group consisted of 33 healthy volunteers. The activity of PC, AT, FPS, APCR and the concentration of TM was estimated in all representatives.Results: The comparison of the examined coagulation parameters between the patients with SCS and the healthy individuals revealed significantly higher mean PC activity and mean FPS activity in the SCS group. Mean TM concentration was significantly lower in patients with SCS compared with the control group. The differences in APCR and AT activity were not significant. We did not prove any statistically significant correlations between the examined coagulation parameters and hormonal parameters. We did not find any correlation between the concentration of cortisol and basic coagulation parameters such as international normalized ratio, activated partial thromboplastin time or fibrinogen in the group with SCS either. Conclusions: The patients with SCS present disturbances in endogenous anticoagulation system defined as PC, FPS activity and TM concentration. This finding suggests an impact of mild autonomic cortisol overproduction on coagulation system.

show abstract

Section: Discussioncontrasting

confidence: 75%

The estimation of selected endogenous anticoagulation system parameters in patients with subclinical Cushing's syndrome

Świątkowska−Stodulska

Kaniuka-Jakubowska²,

Wiśniewski³

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Furthermore, changes in THBD gene expression reflect endothelial activation and damage, an initial step of atherosclerosis. 30 The multiple physiological effects of the THDB gene in thrombosis, inflammation, and atherosclerosis implicate an association between THDB gene polymorphisms and vascular disease. Several reports have analyzed the contribution of the THBD gene to IS, but the relationship between THBD gene polymorphisms and IS has remained ambivalent at best.…”

Section: The Associated Genes and Potential Biological Mechanism Undementioning

confidence: 99%

Variants in the Atherogenic ALOX5AP, THBD, and KNG1 Genes Potentiate the Risk of Ischemic Stroke via a Genetic Main Effect and Epistatic Interactions in a Chinese Population

Liu

Song

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

Tu-P7:121 Soluble thrombomdulin (STM) — A molecular marker of endothelial cell injury in children and adolescents with type 1 diabetes

Cited by 2 publications

References 0 publications

The estimation of selected endogenous anticoagulation system parameters in patients with subclinical Cushing's syndrome

The estimation of selected endogenous anticoagulation system parameters in patients with subclinical Cushing's syndrome

Variants in the Atherogenic ALOX5AP, THBD, and KNG1 Genes Potentiate the Risk of Ischemic Stroke via a Genetic Main Effect and Epistatic Interactions in a Chinese Population

Contact Info

Product

Resources

About