Tuberculosis and autoimmune hemolytic anemia: Case report and literature review

Bahbahani, Hussain; Al-Rashed, Maryam; Almahmeed, Mohammed

doi:10.4103/1658-5127.146953

Cited by 8 publications

(7 citation statements)

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“…These are limited by heterogeneity considering that one of the studies used serological prevalence, two included clinically diagnosed TB patients, and another was carried out on Egyptian mummies. An attendant problem with malaria among TB patients is the overlap of symptoms, clinical signs, and complications such as anaemia, cough, and respiratory distress [11, 12]. This delays the diagnosis and initiation of treatment of either infection, yet malaria has the potential to increase mortality of TB patients [13].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda

Baluku

Nassozi

Gyagenda

et al. 2019

Journal of Tropical Medicine

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The prevalence of malaria and tuberculosis (TB) coinfection is not well established in countries that are highly burdened for both diseases. Malaria could impair TB containment and increase mortality of TB patients. The objective of this study was to determine the prevalence of malaria/TB coinfection among bacteriologically confirmed adult TB patients at a national TB treatment centre in Uganda. Using a cross-sectional study design we enrolled 363 bacteriologically confirmed adult TB patients, and data on demographics and medical history was collected. Blood samples were tested for malaria blood smear, rapid malaria diagnostic test (RDT), complete blood count, haematological film analysis, HIV serology, and CD4+ and CD8+ cell counts. Malaria was defined as either a positive blood smear or RDT. The study participants were mostly male (61.4%), with a median age of 31 (interquartile range, IQR: 25-39) years, and 35.8% were HIV positive. The prevalence of malaria was 2.2% (8/363) on the overall and 5% (3/58) among participants with rifampicin resistance. A triple infection of HIV, malaria, and rifampicin resistant TB was observed in 3 participants. The prevalence of malaria among TB patients is low, and further evaluation of the epidemiological, clinical, and immunological interaction of the two diseases is warranted.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda

Baluku

Nassozi

Gyagenda

et al. 2019

Journal of Tropical Medicine

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“…2 TB may also associated with a Coombs positive autoimmune haemolytic anaemia (AIHA). 3 There are separate reports of HLH and AIHA associated with TB, but to the best of our knowledge, both entities in the same patient associated with TB have not been reported previously.…”

Section: Introductionmentioning

confidence: 78%

Autoimmune haemolytic anaemia and haemophagocytic lymphohistiocytosis in an adolescent boy with tuberculosis: an unusual association

et al. 2017

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“…All patients, except three, belonged to the nations from where their illness was reported. The three patients, reported from Kuwait [ 26 ], France [ 34 ] and Saudi Arabia [ 37 ], originated from Ethiopia, Morocco and Indonesia respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The combination of anti-tuberculosis medicines, blood transfusion and steroids was needed in 29% (6/21). Out of the patients with warm type, only one 14% (1/7) needed steroids [ 26 ], whereas it was 33% in cold (2/6) and 100% in mixed (2/2). Half of the patients who received steroids for AIHA had disseminated TB, whereas only 15% had disseminated TB in the non-steroid group.…”

Section: Resultsmentioning

confidence: 99%

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Tuberculosis induced autoimmune haemolytic anaemia: a systematic review to find out common clinical presentations, investigation findings and the treatment options

Rathish

Siribaddana

2018

Allergy Asthma Clin Immunol

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BackgroundTuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of published reports.MethodsPubMed, Trip, Google Scholar, Science Direct, Cochrane Library, Open-Grey, Grey literature report and the reference lists of the selected articles were searched for case reports in English on tuberculosis induced auto-immune haemolytic anaemia. PRISMA statement was used for systematic review. Quality assessment of the selected reports was done using the CARE guidelines.ResultsTwenty-one articles out of 135 search results were included. Thirty-three percent of patients were reported from India. More than half had fever and pallor. The mean haemoglobin was 5.77 g/dl (SD 2.2). Positive direct coombs test was seen in all patients. Pulmonary tuberculosis (43%) was most prevalent. Twenty-nine percent of patients needed a combination of anti-tuberculosis medicines, blood transfusion and steroids. Higher percentage of disseminated TB induced AIHA (67%) needed steroids in comparison to the other types of TB induced AIHA (13%).ConclusionsRarer complications of tuberculosis such as auto-immune haemolytic anaemia should be looked for especially in disease-endemic areas. Blood transfusion and steroids are additional treatment options along with the anti-tuberculosis medicines.Electronic supplementary materialThe online version of this article (10.1186/s13223-018-0236-y) contains supplementary material, which is available to authorized users.

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Tuberculosis and autoimmune hemolytic anemia: Case report and literature review

Cited by 8 publications

References 0 publications

Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda

Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda

Autoimmune haemolytic anaemia and haemophagocytic lymphohistiocytosis in an adolescent boy with tuberculosis: an unusual association

Tuberculosis induced autoimmune haemolytic anaemia: a systematic review to find out common clinical presentations, investigation findings and the treatment options

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