2017
DOI: 10.1016/j.pcl.2017.03.010
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Tuberculosis in Children

Abstract: Synopsis Mycobacterium tuberculosis is the leading cause of death worldwide from a single bacterial pathogen. World Health Organization (WHO) estimates that annually, 1 million children have TB disease and many more harbor a latent form of infection. However, accurate estimates are hindered by under-recognition and challenges in diagnosis; to date, an accurate diagnostic test to confirm TB in children does not exist. TB treatment is lengthy, but outcomes are generally favorable with timely initiation. As we mo… Show more

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Cited by 97 publications
(114 citation statements)
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“…Primary immunodeficiency such as Chronic Granulomatous Disease (CGD), Mendelian susceptibility to Mycobacterial diseases, Severe Combined Immunodeficiency (SCID) and secondary HIV immunity, among others, are known to be risk factors for TB disease [12]. Male gender, periodontal disease, alcohol abuse, cancer, HIV infection, and cystic fibrosis are all predisposing factors for SAG infection [13].…”
Section: Discussionmentioning
confidence: 99%
“…Primary immunodeficiency such as Chronic Granulomatous Disease (CGD), Mendelian susceptibility to Mycobacterial diseases, Severe Combined Immunodeficiency (SCID) and secondary HIV immunity, among others, are known to be risk factors for TB disease [12]. Male gender, periodontal disease, alcohol abuse, cancer, HIV infection, and cystic fibrosis are all predisposing factors for SAG infection [13].…”
Section: Discussionmentioning
confidence: 99%
“…Primäre Immundefizienzsyndrome wie septische Granulomatose, eine Suszeptibilität nach den Mendel’schen Regeln für mykobakterielle Erkrankungen, schwere kombinierte Immundefekte (severe combined immunodeficiency, SCID) und eine sekundäre HIV-Immunität sind u.a. als Risikofaktoren für eine TB-Erkrankung bekannt [12]. Männliches Geschlecht, parodontale Erkrankungen, Alkoholabusus, Krebserkrankungen, HIV-Infektion und zystische Fibrose sind allesamt prädisponierende Faktoren für eine SAG-Infektion [13].…”
Section: Diskussionunclassified
“…50 Chang et al 60 Mycobacterium tuberculosis is the leading cause of death worldwide from a single bacterial pathogen. 63 The World Health…”
Section: Respiratory Syncytial Virus (Rsv) Infection In Infants and Ymentioning
confidence: 99%
“…Mycobacterium tuberculosis is the leading cause of death worldwide from a single bacterial pathogen . The World Health Organization estimates that annually one million children have tuberculosis (TB) disease and many more harbor a latent form.…”
Section: Introductionmentioning
confidence: 99%