Tuberculosis in solid organ transplantation: Prospects and challenges in the brazilian context

Abstract

The management of tuberculosis (TB) in candidates and recipients of solid organs poses several challenges. Among them, TB diagnosis is often delayed by the atypical presentation of the disease and difficulties related to the anti-TB drugs toxicity and the interaction with immunosuppressive drugs. This review includes relevant articles published in the last 20 years and also takes into account the current Brazilian recommendations for the diagnosis and therapeutic management of TB in solid organ transplant (SOT) recipients. It also attempts to provide useful recommendations to assist physicians as to the patient care, and presents the main limitations for a better approach upon considering the Brazilian scenario.