Tuberculosis Lymphadenitis in Ethiopia

Biadglegne, Fantahun; Tesfaye, Weghata; Anagaw, Belay; Tessema, Belay; Debebe, Tewodrose; Anagaw, Berhanu; Mulu, Andargachew; Sack, Ulrich; Rodloff, Arne C.

doi:10.7883/yoken.66.263

Cited by 29 publications

(24 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These goals are not being achieved in many regions of the country though anti-tuberculosis drugs are available. This might be due to either patient non-adherence to treatment or clinicians’ non-adherence to the national treatment guidelines or both [ 44 ].…”

Section: Reviewmentioning

confidence: 99%

Multidrug-resistant tuberculosis in Ethiopia: efforts to expand diagnostic services, treatment and care

Biadglegne

Sack

Rodloff

2014

Antimicrob Resist Infect Control

Self Cite

View full text Add to dashboard Cite

The emergence of drug-resistant tuberculosis (TB), particularly multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB, is a major public health problem. The purpose of this review is to describe the current status of MDR-TB and factors that increase the risk of this infection. We conducted a systematic review of the literature on MDR-TB in Ethiopia. Out of 766 articles, 23 were found to meet eligibility criteria and included in this review. Among the 23 papers, six of them reported high prevalence of MDR-TB in the range of 3.3%-46.3%. Likewise, two studies reported XDR-TB in the range of 1% - 4.4% in Ethiopia. The most powerful predictor of the emergence of MDR-TB reported in Ethiopia is previous exposure to anti-TB drug treatment. This review indicated that MDR-TB in Ethiopia is a serious public health problem that needs to be addressed urgently. Strengthening early case detection and proper treatment of drug-susceptible TB in accordance with World Health Organization (WHO) treatment guidelines to ensure adequate treatment success rates is critical. Consequently, efforts have been made to a rapidly increase MDR-TB diagnosis as well as the number of treatment sites to implement a directly observed treatment, short-course (DOTS) plus strategy to interrupt transmission of MDR-TB.

show abstract

Section: Reviewmentioning

confidence: 99%

Multidrug-resistant tuberculosis in Ethiopia: efforts to expand diagnostic services, treatment and care

Biadglegne

Sack

Rodloff

2014

Antimicrob Resist Infect Control

Self Cite

View full text Add to dashboard Cite

show abstract

“…The prevalence of all forms of TB is estimated at 261 per 100,000 population, leading to an annual mortality rate of 64 per 100,000 [3]. In Ethiopia, extra pulmonary tuberculosis (EPTB) accounted for 34.8% of TB cases with more than 80% of cases presenting as Tuberculosis lymphadenitis cases [4]. Even though early case detection and treatment is one of the pillars of the TB control program, extra pulmonary tuberculosis is a significant true challenge in its different clinical presentation.…”

Section: Introductionmentioning

confidence: 99%

Concentration of fine needle aspirates similar to molecular method improves sensitivity of the diagnosis of tuberculous lymphadenitis in Addis Ababa, Ethiopia

et al. 2017

View full text Add to dashboard Cite

BackgroundTuberculous lymphadenitis (TBLN) diagnosis has been a true challenge solely by clinical evidence in developing countries, due to limited the diagnostic facility on hand. However, the availability and affordability of available diagnostic tools in resource-limited settings like Ethiopia necessitates the quest for other techniques with added value over direct Z-N microscopy. Therefore, we aimed at to assess whether the concentration of lymph node aspirate similarly improves the detection rate of tuberculous lymphadenitis or not.Materials and methodsA cross-sectional study design was conducted on 132 individual subjects presumptive for tuberculous lymphadenitis from February to October 2013 in Addis Ababa, Ethiopia. Fine needle aspirate (FNA) samples were collected from the cases and cultured on Löwenstein-Jensen (LJ) slants. Identification of species and strains of mycobacteria was made by region of difference (RD) based polymerase chain reaction (PCR). Data entry and statistical analyses were performed by SPSS version 20. The confidence level of 95% was used for statistical significance.ResultA total of 132 study subjects were included in our study. Of these 56.1% (74/132) were positive for M. tuberculosis on culture. The detection rate of direct smear microscopy and the concentration method were 29.5 and 65.2% respectively. The sensitivity of direct smear microscopy was 43.2%, for concentrated smear microscopy 94.5%, for PCR 93.2% and for cytomorphology 95.4%. The level of agreement of concentrated ZN smear microscopy was 0.62 which was very similar with kappa of 0.58 of molecular (PCR) technique. AFB positivity by the concentration method and molecular method was increased in caseous aspirates as compared to purulent and hemorrhagic aspirates though it was not statistically significant (p-value = 0.18) and (p = 0.62) respectively.ConclusionThe concentration of FNA (Fine Needle Aspirate) aspirates for acid-fast smear microscopy similarly improves the sensitivity of acid fast bacilli in diagnosing of TBLN.

show abstract

“…Extra‐pulmonary tuberculosis (EPTB), particularly tuberculous lymphadenitis (TBL), continues to be a major health problem in developing countries . In Ethiopia, EPTB with TBL is the most common type accounting for 80% of EPTB . However, EPTB as a much more obscure process is more difficult to diagnose than pulmonary TB.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of fluorescent light‐emitting diode microscopy for tuberculous lymphadenitis in a high‐burden setting

Abdissa

Tadesse

Abdella

et al. 2015

Tropical Med Int Health

View full text Add to dashboard Cite

The LED microscopy for tuberculous lymphadenitis had significantly higher sensitivity and shorter screening time than Ziehl-Neelsen microscopy. Use of LED microscopy among cases classified as suppurative abscess on fine-needle aspirate cytology improves evidence-based diagnosis of presumptive tuberculous lymphadenitis cases. Moreover, LED microscopy could be considered as an alternative approach in settings where fine-needle aspirate cytology is impractical.

show abstract

Tuberculosis Lymphadenitis in Ethiopia

Cited by 29 publications

References 21 publications

Multidrug-resistant tuberculosis in Ethiopia: efforts to expand diagnostic services, treatment and care

Multidrug-resistant tuberculosis in Ethiopia: efforts to expand diagnostic services, treatment and care

Concentration of fine needle aspirates similar to molecular method improves sensitivity of the diagnosis of tuberculous lymphadenitis in Addis Ababa, Ethiopia

Diagnostic performance of fluorescent light‐emitting diode microscopy for tuberculous lymphadenitis in a high‐burden setting

Contact Info

Product

Resources

About