Tuberculosis - The spoil sport

Govindarajan, MJ; Nagaraj,; Ravikumar, .; Kalyanpur, Arjun; Kallur,

doi:10.4103/0971-3026.41843

Cited by 2 publications

(2 citation statements)

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“…PUO is one of the non-oncological indications of whole-body FDG-PET CT. Its high sensitivity in detecting malignant lesions, infections and other inflammatory processes makes it an important tool in the investigation of a patient with PUO. 8 , 9 Increased FDG uptake in active TB can be seen in diverse anatomical locations, mimicking malignant processes. FDG-PET CT does not demonstrate a characteristic pattern to differentiate between benign and malignant lesions.…”

Section: Discussionmentioning

confidence: 99%

Isolated splenic tuberculosis detected only on FDG-PET

et al. 2017

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Tuberculosis (TB) is a well-known problem in developing countries but has shown resurgence in non-endemic populations in recent years. This may be due to increased migration, and is more commonly seen in populations with lowered immunity due to various causes. Isolated splenic TB is extremely rare, especially in immunocompetent patients. In this case report we have described an immunocompetent female, presenting to the physician with fever, without any chest symptoms or weight loss. All microbiological investigations for pyrexia of unknown origin were done, which did not reveal the cause. Imaging modalities including chest radiographs and ultrasound did not reveal any significant abnormalities. Finally, fluorodeoxyglucose (FDG)-positron emission tomography (PET) showed FDG-avid multiple focal nodular lesions (not seen on contrast and non-contrast CT). MRI including diffusion-weighted imaging did not reveal the splenic nodules. PET-directed CT-guided biopsy of the splenic lesions was performed, with histopathology findings suggestive of TB. Atypical clinical and imaging presentations are not uncommon in TB. History of exposure to TB may not be present. Nevertheless, TB should be kept in mind as a differential diagnosis in patients with fever, and extensive search of the source is important. Splenic TB reported in literature to date has been detected by morphological imaging modalities such as ultrasound or contrast CT. Ours is possibly the first case reported in the English literature where FDG-PET has detected the lesions that other imaging modalities failed to show, thus illustrating the role of molecular imaging in the evaluation of pyrexia of unknown origin to localize the site of affection.

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Section: Discussionmentioning

confidence: 99%

Isolated splenic tuberculosis detected only on FDG-PET

et al. 2017

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“…[ 3 ] TB of the hip joint accounts for about 15% of cases of tubercular osteomyelitis. [ 4 ] Although the PET/CT appearances of pulmonary and extrapulmonary TB have been described in the past,[ 3 5 6 7 ] there are limited reports on the role of PET/CT in the evaluation of TB of the hip joint. [ 8 ] Increased FDG uptake has been visualized in regions of active granulomatous inflammation in musculoskeletal TB, with cold areas in necrosed tissue containing pus.…”

Section: Discussionmentioning

confidence: 99%