Tubes and the single C. elegans excretory cell

Buechner, Matthew

doi:10.1016/s0962-8924(02)02364-4

Cited by 90 publications

(109 citation statements)

References 56 publications

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“…( 2016), Martino, Ma and Leulier ( 2017), Smith et al. ( 2017), Tropini, Earle, Huang and Sonnenburg ( 2017); excretory system: King and Goldstein (1985), Buechner (2002), Gautam, Verma and Tapadia ( 2017); sleep and circadian system: Raizen et al. ( 2008); Trojanowski and Raizen (2016); Miyazaki, Liu and Hayashi ( 2017); others: Micchelli and Perrimon (2006), Ohlstein and Spradling (2006), Chaturvedi, Reichert, Gunage and VijayRaghavan ( 2017), Gunage, Dhanyasi, Reichert and VijayRaghavan (2017)…”

Section: Research Organisms For Agingmentioning

confidence: 99%

The African turquoise killifish: A research organism to study vertebrate aging and diapause

Brunet²

2018

Aging Cell

135

118

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SummaryThe African turquoise killifish has recently gained significant traction as a new research organism in the aging field. Our understanding of aging has strongly benefited from canonical research organisms—yeast, C. elegans, Drosophila, zebrafish, and mice. Many characteristics that are essential to understand aging—for example, the adaptive immune system or the hypothalamo‐pituitary axis—are only present in vertebrates (zebrafish and mice). However, zebrafish and mice live more than 3 years and their relatively long lifespans are not compatible with high‐throughput studies. Therefore, the turquoise killifish, a vertebrate with a naturally compressed lifespan of only 4–6 months, fills an essential gap to understand aging. With a recently developed genomic and genetic toolkit, the turquoise killifish not only provides practical advantages for lifespan and longitudinal experiments, but also allows more systematic characterizations of the interplay between genetics and environment during vertebrate aging. Interestingly, the turquoise killifish can also enter a long‐term dormant state during development called diapause. Killifish embryos in diapause already have some organs and tissues, and they can last in this state for years, exhibiting exceptional resistance to stress and to damages due to the passage of time. Understanding the diapause state could give new insights into strategies to prevent the damage caused by aging and to better preserve organs, tissues, and cells. Thus, the African turquoise killifish brings two interesting aspects to the aging field—a compressed lifespan and a long‐term resistant diapause state, both of which should spark new discoveries in the field.

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Section: Research Organisms For Agingmentioning

confidence: 99%

The African turquoise killifish: A research organism to study vertebrate aging and diapause

Brunet²

2018

Aging Cell

135

118

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“…The exception is an extraordinary organ in the nematode C. elegans, termed the excretory cell, which regulates osmolarity; it is extraordinary because an entire organ is formed from a single cell. As described by Buechner [4], the excretory cell is shaped like a letter 'H' and comprises two hollow canals, one on each side of the animal, which are connected by a bridge to a duct, or pore, and the 'outside'. The lumens of the canals are surrounded by the continuous apical membrane of the cell, without discontinuities formed by lateral membranes of interconnected cells characteristic of multicellular tubes.…”

Section: Formation Of a Tube -So Many Possibilitiesmentioning

confidence: 99%

“…Tube elongation and migration require changes in the dynamics of membrane and cytoskeleton (Figures 2 and 3). Morphological studies of tube outgrowth and extension reveal that tip cells extend filopodia and lamellipodia that form long narrow protrusions into the surrounding extracellular environment [4,5,11]. Although many pathways involving growth-factor receptors participate in the induction of tube elongation and migration (see above), in most cases little is known about their downstream effector pathways.…”

Section: Forming Tubes: Downstream Effectors Of Master Regulators Andmentioning

confidence: 99%

“…Buechner [4] described genetic studies in the simplest system for cell extension, the excretory cell in C. elegans, that revealed that cell outgrowth is reduced by mutations in the receptors of basement-membrane (ECM), such as pat-3/β1-integrin, proteins of the basement membrane, such as laminins and perlecan, migration cues, such as netrin and its receptor, and proteins involved in intracellular integrin signaling and changes to the cytoskeletal organization [4]. Similarly, mutations in integrins inhibit proper extension of lamellipodia and cell migration in developing salivary gland tubes in Drosophila [5].…”

Section: Forming Tubes: Downstream Effectors Of Master Regulators Andmentioning

confidence: 99%

“…Mechanisms involved in these changes to the cell shape are poorly understood, although Andrew and colleagues [5] noted that unknown downstream targets of transcription factor Fkh are required for the changes in the cell shape and apical constriction, as downstream targets (klar, crb) of Hairy/Hkb are involved in determining the identity of apical membranes (see above). In the excretory cell of C. elegans, several groups of genes are involved in the formation of lumen [4]. Buechner described how loss-of-function mutations in one group, Exc, results in the formation of a series of fluid-filled cysts of varying diameter along the length of the cell, rather than one continuous narrow lumen.…”

Section: Forming Tubes: Downstream Effectors Of Master Regulators Andmentioning

confidence: 99%

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Tube morphogenesis: closure, but many openings remain

Nelson

2003

Trends in Cell Biology

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Cell Migration

Trepat

Chen

Jacobson

2012

Comprehensive Physiology

402

298

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Cell migration is fundamental to establishing and maintaining the proper organization of multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell locomotion, from large-scale migrations of epithelial sheets during gastrulation, to the movement of individual cells during development of the nervous system. In an adult organism, cell migration is essential for proper immune response, wound repair, and tissue homeostasis, while aberrant cell migration is found in various pathologies. Indeed, as our knowledge of migration increases, we can look forward to, for example, abating the spread of highly malignant cancer cells, retarding the invasion of white cells in the inflammatory process, or enhancing the healing of wounds. This article is organized in two main sections. The first section is devoted to the single-cell migrating in isolation such as occurs when leukocytes migrate during the immune response or when fibroblasts squeeze through connective tissue. The second section is devoted to cells collectively migrating as part of multicellular clusters or sheets. This second type of migration is prevalent in development, wound healing, and in some forms of cancer metastasis.

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Tubes and the single C. elegans excretory cell

Cited by 90 publications

References 56 publications

The African turquoise killifish: A research organism to study vertebrate aging and diapause

The African turquoise killifish: A research organism to study vertebrate aging and diapause

Tube morphogenesis: closure, but many openings remain

Cell Migration

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