Tubulysins are Essential for the Preying of Ciliates by Myxobacteria

Yu, Un-Young; Kim, Jiha; Park, S. Y.; Cho, Kyungyun

doi:10.1007/s12275-023-00056-2

Cited by 3 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondary metabolites with fungicidal, bactericidal or "toxic" activity on ciliates are produced by myxobacteria in great variety [35][36][37], but relatively few compounds have been investigated specifically in the context of predation. Here, it is difficult to differentiate whether the predominant function of an antibiotic lies in killing prey for consumption, or in inhibiting the growth of competitors, a strategy also used by non-predatory bacteria.…”

Section: Secreted Predation Factorsmentioning

confidence: 99%

Two reasons to kill: predation and kin discrimination in myxobacteria

2023

View full text Add to dashboard Cite

Myxobacteria are social microbial predators that use cell–cell contacts to identify bacterial or fungal prey and to differentiate kin relatives to initiate cellular responses. For prey killing, they assemble Tad-like and type III-like secretion systems at contact sites. For kin discrimination (KD), they assemble outer membrane exchange complexes composed of the TraA and TraB receptors at contacts sites. A type VI secretion system and Rhs proteins also mediate KD. Following cellular recognition, these systems deliver appropriate effectors into target cells. For prey, this leads to cell death and lysis for nutrient consumption by myxobacteria. In KD, a panel of effectors are delivered, and if adjacent cells are clonal cells, resistance ensues because they express a cognate panel of immunity factors; while nonkin lack complete immunity and are intoxicated. This review compares and contrasts recent findings from these systems in myxobacteria.

show abstract

Section: Secreted Predation Factorsmentioning

confidence: 99%