Tumor and endothelial cells collaborate via transcellular receptor complexes

Sarabipour, Sarvenaz; Gabhann, Feilim Mac

doi:10.1002/path.5185

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…NRP-1 promotes vascular endothelial growth factor receptor2 (VEGFR2) signal transduction induced by galectin-1 [ 36 ]. Meanwhile, VEGFR2/NRP-1 trans-complex reduces angiogenesis and aggravates the hypoxic environment of PDAC [ 37 , 38 ], which promotes the activation of TAM and MDSC. Interestingly, IL-8 secreted by CAFs can promote high expression of NRP-1, while in PDAC, galectin-1 can induce more IL-8 secretion by CAFs [ 39 ].…”

Section: Galectin-1 Is Involved In the Immune Evasion Of Pdacmentioning

confidence: 99%

Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma

Jiang

Zhang

Sha

et al. 2022

Cancers

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and is highly immune tolerant. Although there is immune cell infiltration in PDAC tissues, most of the immune cells do not function properly and, therefore, the prognosis of PDAC is very poor. Galectins are carbohydrate-binding proteins that are intimately involved in the proliferation and metastasis of tumor cells and, in particular, play a crucial role in the immune evasion of tumor cells. Galectins induce abnormal functions and reduce numbers of tumor-associated macrophages (TAM), natural killer cells (NK), T cells and B cells. It further promotes fibrosis of tissues surrounding PDAC, enhances local cellular metabolism, and ultimately constructs tumor immune privileged areas to induce immune evasion behavior of tumor cells. Here, we summarize the respective mechanisms of action played by different Galectins in the process of immune escape from PDAC, focusing on the mechanism of action of Galectin-1. Galectins cause imbalance between tumor immunity and anti-tumor immunity by coordinating the function and number of immune cells, which leads to the development and progression of PDAC.

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Section: Galectin-1 Is Involved In the Immune Evasion Of Pdacmentioning

confidence: 99%

Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma

Jiang

Zhang

Sha

et al. 2022

Cancers

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“…The formation of cis NRP1-VEGFA-VEGFR2 complexes within cells plays a crucial role in enhancing angiogenesis. [ 76 – 78 ] However, trans-NRP1-VEGFA-VEGFR2 complexes across cells play an inhibitory role in angiogenesis. [ 78 ] Pan et al [ 79 ] using a mouse xenograft tumor model, determined that antibodies that blocked VEGFA binding to NRP1 enhanced the anti-tumor effect of anti-VEGFA antibodies.…”

Section: Nrp1 Promotes Tumor Angiogenesismentioning

confidence: 99%

“…[ 76 – 78 ] However, trans-NRP1-VEGFA-VEGFR2 complexes across cells play an inhibitory role in angiogenesis. [ 78 ] Pan et al [ 79 ] using a mouse xenograft tumor model, determined that antibodies that blocked VEGFA binding to NRP1 enhanced the anti-tumor effect of anti-VEGFA antibodies. Interestingly, in acute myeloid leukemia (AML), SEMA3A may partially reverse AML progression by inducing VEGFA overexpression.…”

Section: Nrp1 Promotes Tumor Angiogenesismentioning

confidence: 99%

Targeting neuropilin-1 interactions is a promising anti-tumor strategy

Liu

Zhong

et al. 2020

Chinese Medical Journal

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Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in neurons, but subsequent studies have demonstrated its surface expression in cells from the endothelium and lymph nodes. NRP1 has been demonstrated to be involved in the occurrence and development of a variety of cancers. NRP1 interacts with various cytokines, such as vascular endothelial growth factor family and its receptor and transforming growth factor β1 and its receptor, to affect tumor angiogenesis, tumor proliferation, and migration. In addition, NRP1 + regulatory T cells (Tregs) play an inhibitory role in tumor immunity. High numbers of NRP1 + Tregs were associated with cancer prognosis. Targeting NRP1 has shown promise, and antagonists against NRP1 have had therapeutic efficacy in preliminary clinical studies. NRP1 treatment modalities using nanomaterials, targeted drugs, oncolytic viruses, and radio-chemotherapy have gradually been developed. Hence, we reviewed the use of NRP1 in the context of tumorigenesis, progression, and treatment.

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New insights into the role of co-receptor neuropilins in tumour angiogenesis and lymphangiogenesis and targeted therapy strategies

Zhao

Chen

et al. 2020

Journal of Drug Targeting

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Tumor and endothelial cells collaborate via transcellular receptor complexes

Cited by 4 publications

References 9 publications

Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma

Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma

Targeting neuropilin-1 interactions is a promising anti-tumor strategy

New insights into the role of co-receptor neuropilins in tumour angiogenesis and lymphangiogenesis and targeted therapy strategies

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