Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

Weidner, Noel; Folkman, Judah; Pozza, F; Bevilacqua, P.; Allred, Elizabeth N.; Moore, Dan H.; Meli, S; Gasparini, Giampietro

doi:10.1093/jnci/84.24.1875

Cited by 1,655 publications

(977 citation statements)

References 0 publications

Supporting

Mentioning

902

Contrasting

Unclassified

Order By: Relevance

“…It is also thought that the degree of tumour angiogenesis is related to clinical outcome, suggesting that angiogenic properties are correlated with tumour aggressiveness (Bosari et al, 1992;Weidner et al, 1992;Gasparini et al, 1994). In a previous study (Maeda et al, 1995) we also demonstrated that the microvessel count is an independent prognostic indicator in patients with gastric carcinoma.…”

supporting

confidence: 53%

Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma

Maeda

Chung²,

Ogawa³

et al. 1996

Br J Cancer

138

108

View full text Add to dashboard Cite

Summary It is known that angiogenesis plays an important role in the growth and metastasis of solid tumours. Several angiogenic factors have been identified and platelet-derived endothelial cell growth factor (PD-ECGF) is thought to be one such factor. Recently, it was reported that thymidine phosphorylase (dThdPase) is identical to PD-ECGF. Using immunohistochemical staining with an anti-dThdPase antibody, we investigated the correlation between dThdPase expression and the microvessel density in 120 gastric carcinomas. The microvessel density, determined by immunostaining for factor VIII-related antigen, was significantly higher in dThdPase-positive tumours than in dThdPase-negative tumours. There was a significant correlation between dThdPase expression and the increment of microvessel density. Moreover, regarding distant organ metastasis, the frequency of hepatic metastasis was significantly higher (P<0.01) in patients with dThdPase-positive tumours than in those with dThdPase-negative tumours. In summary, it was suggested that dThdPase expression is closely associated with the promotion of angiogenesis and hepatic metastasis in gastric carcinoma.

show abstract

supporting

confidence: 53%

Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma

Maeda

Chung²,

Ogawa³

et al. 1996

Br J Cancer

138

108

View full text Add to dashboard Cite

show abstract

“…The slides were treated as above for the final steps of immunohistochemistry. Vessel counts on histological slides were performed according to a method described by Weidner et al 47 for tumors. Since these tissues are usually associated with a high vessel count, we have adapted this method.…”

Section: Elisa Quantification Of Bfgf In Vivomentioning

confidence: 99%

Angiogenesis induced in muscle by a recombinant adenovirus expressing functional isoforms of basic fibroblast growth factor

et al. 1999

View full text Add to dashboard Cite

“…8,10,12 HIF-1 expression may have prognostic and therapeutic consequences because angiogenesis is a prognostic indicator. 13,14 Although the precise mechanism, and especially the initiation, of tumor angiogenesis is not understood fully, antiangiogenic therapies are under rapid development and clinical evaluation. 15 Along with intratumoral microvessel density, increased VEGF expression is associated with a poor prognosis; therefore.…”

mentioning

confidence: 99%

Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma

Bos

Groep

Greijer

et al. 2003

Cancer

465

362

View full text Add to dashboard Cite

BACKGROUNDHypoxia‐inducible factor‐1 (HIF‐1) is a transcription factor that plays an important role in tumor growth and metastasis by regulating energy metabolism and inducing angiogenesis to survive cellular hypoxia. Increased levels of HIF‐1α, the O2‐regulated subunit of HIF‐1, were noted during breast carcinogenesis. In this study, the prognostic value of HIF‐1α expression and its correlation with various clinicopathologic variables in patients with invasive breast carcinoma were investigated.METHODSExpression levels of HIF‐1α, HER‐2/neu, estrogen receptor, and progesterone receptor were analyzed in 150 patients with early‐stage breast carcinoma by immunohistochemistry. HER‐2/neu gene amplification was investigated with automated fluorescent in situ hybridization. The mitotic activity index, histologic grade, and tumor type were assessed in hematoxylin and eosinstained specimens. Clinical data included disease‐free survival, overall survival, lymph node status, and tumor size. The data were analyzed with two‐sided univariate and multivariate tests, with P values < 0.05 considered significant.RESULTSHigh levels of HIF‐1α had an association of borderline significance with decreased overall survival (P = 0.059) and disease‐free survival (P = 0.110) that was ascribed completely to the subgroup of women with lymph node negative tumors (n = 81 patients; P = 0.008 and P = 0.004, respectively). HER‐2/neu immunoreactivity (P < 0.001) and gene amplification (P < 0.001), vascular endothelial growth factor expression (P = 0.016), and Ki‐67 expression (P < 0.001) were correlated strongly with HIF‐1α positivity, although none of those factors had an independent effect on survival.CONCLUSIONSIncreased levels of HIF‐1α were associated independently with shortened survival in patients with lymph node negative breast carcinoma. Therefore, the use of immunohistochemical assessment of HIF‐1α as a new predictor of poor outcome may improve clinical decision‐making regarding adjuvant treatment of patients with lymph node negative breast carcinoma. Cancer 2003;97:1573–81. © 2003 American Cancer Society.DOI 10.1002/cncr.11246

show abstract

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

Abstract: Such an indicator would be useful in selection of those node-negative patients with breast carcinoma who are at high risk for having occult metastasis at presentation. These patients could then be given systemic adjuvant therapy.

Cited by 1,655 publications

References 0 publications

Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma

Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma

Angiogenesis induced in muscle by a recombinant adenovirus expressing functional isoforms of basic fibroblast growth factor

Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma

Contact Info

Product

Resources

About