Tumor-Associated Circulating Microparticles: A Novel Clinical Tool for Screening and Therapy Monitoring of HCC and other Epithelial Neoplasia

Willms, Arnulf; Müller, Carl; Julich, Henrike; Klein, NJ; Schwab, Roxana; Richardsen, I.; Schaaf, Sebastian; Geis, Christian; Krawczyk, Marcin; Lammert, Frank; Schuppan, Detlef; Lukacs‐Kornek, Veronika; Kornek, Miroslaw

doi:10.1016/s0168-8278(16)00475-x

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Willms et al 26 studied two exosome contents, Poroyko et al 23 showed nine different miRNAs in exosomes, and Fan et al 20 studied four different types of populations: each content and population was considered as a separate study for our analysis. Thus, the 13 articles in this meta-analysis included 25 studies comprising 1,338 cancer cases and 1,075 controls.…”

Section: Study Characteristics and Quality Assessmentsmentioning

confidence: 99%

“…The sample sizes of the studies ranged from 19 to 581, and all LC patients received definitive diagnosis by histopathologic examination of specimens. The paired controls comprised healthy individuals, 18,20,22,23,[26][27][28][29] non-LC controls, 19,21,24,26,29 and a population with a relevant negative maker. 17,18 Additionally, the specimen types were serum in 13 studies 23,26,28,29 and plasma in 12 studies.…”

Section: Study Characteristics and Quality Assessmentsmentioning

confidence: 99%

“…The paired controls comprised healthy individuals, 18,20,22,23,[26][27][28][29] non-LC controls, 19,21,24,26,29 and a population with a relevant negative maker. 17,18 Additionally, the specimen types were serum in 13 studies 23,26,28,29 and plasma in 12 studies. [17][18][19][20][21][22]24,25,27 Publication languages were restricted to English and Chinese.…”

Section: Study Characteristics and Quality Assessmentsmentioning

confidence: 99%

See 2 more Smart Citations

The diagnostic accuracy of liquid exosomes for lung cancer detection: a meta-analysis

Song

Wang

Liu

2018

OTT

View full text Add to dashboard Cite

Purpose: Several studies have suggested that liquid exosomes can be used as biomarkers for the diagnosis of lung cancer (LC). The purpose of this meta-analysis was to investigate the comprehensive diagnostic value of liquid exosomes for LC. Materials and methods: Relevant studies were searched from multiple electronic databases. The quality of the studies was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2 criteria in RevMan 5.3 software. Stata 14.0 software and Meta-disc 1.4 software were used to synthesize the diagnostic parameters. Publication bias was judged according to the Deeks' funnel plot asymmetry test. Results: There were 13 eligible articles that comprised 1,338 LC patients and 1,075 paired controls for the meta-analysis. The pooled sensitivity (SEN), specificity (SPE), diagnostic likelihood ratio positive (DLR+), diagnostic likelihood ratio negative (DLR-), diagnostic OR (DOR), and area under the curve (AUC) of liquid exosomes in diagnosing LC were 0.82 (95% CI: 0.76-0.87), 0.84 (95% CI: 0.77-0.89), 5.27 (95% CI: 3.58-7.75), 0.21 (95% CI: 0.15-0.29), 25.14 (95% CI: 14.25-44.33), and 0.90 (95% CI: 0.87-0.92), respectively. Research based on serum, miRNA, the isolation kit method, one index in exosomes, patient sample size of 50 or greater, and control group size of 50 or greater obtained higher AUC values when the LC type was small cell lung cancer. Conclusion: Liquid exosomes have shown potential as novel biomarkers that could facilitate LC diagnosis. Further prospective studies are still needed to confirm the diagnostic value of liquid exosomes.

show abstract

Section: Study Characteristics and Quality Assessmentsmentioning

confidence: 99%