Tumor attenuation and quantitative analysis of perfusion parameters derived from tri-phasic CT scans in hepatocellular carcinoma

Pang, Guodong; Shao, Chunchun; Lv, Yao; Zhao, Fang

doi:10.1097/md.0000000000025627

Cited by 3 publications

(5 citation statements)

References 32 publications

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“…pCT assesses dynamic variations in tissue iodine concentration over time, allowing to obtain tissue-specific data, including blood flow (BF), blood volume (BV), time to peak concentration (TTP), vascular permeability surface area product (PS), and permeability ( K trans), which can be utilised as biomarkers for tumour vascularization and perfusion. Several authours showed that pCT is a considerable tool for lesion characteritation, treatment response assessment, and prognosis [ 96 – 101 ].…”

Section: Discussionmentioning

confidence: 99%

Conventional, functional and radiomics assessment for intrahepatic cholangiocarcinoma

Granata

Fusco

Belli

et al. 2022

Infect Agents Cancer

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Background This paper offers an assessment of diagnostic tools in the evaluation of Intrahepatic Cholangiocarcinoma (ICC). Methods Several electronic datasets were analysed to search papers on morphological and functional evaluation in ICC patients. Papers published in English language has been scheduled from January 2010 to December 2021. Results We found that 88 clinical studies satisfied our research criteria. Several functional parameters and morphological elements allow a truthful ICC diagnosis. The contrast medium evaluation, during the different phases of contrast studies, support the recognition of several distinctive features of ICC. The imaging tool to employed and the type of contrast medium in magnetic resonance imaging, extracellular or hepatobiliary, should change considering patient, departement, and regional features. Also, Radiomics is an emerging area in the evaluation of ICCs. Post treatment studies are required to evaluate the efficacy and the safety of therapies so as the patient surveillance. Conclusions Several morphological and functional data obtained during Imaging studies allow a truthful ICC diagnosis.

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Section: Discussionmentioning

confidence: 99%

Conventional, functional and radiomics assessment for intrahepatic cholangiocarcinoma

Granata

Fusco

Belli

et al. 2022

Infect Agents Cancer

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“…pCT is highly promising as a functional vascular imaging technique. However, because of the increased radiation dose, CT perfusion of liver is largely unfulfilled clinically [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

“…pCT measures dynamic changes in tissue iodine concentration over time, allowing for calculation of tissue-specific parameters, including blood flow (BF), blood volume (BV), time to peak concentration (TTP), vascular permeability surface area product (PS), and permeability (Ktrans), which can be used as surrogates for tumor vascularization, vascular immaturity, and perfusion pressure. Several researchers reported that pCT is argued to be a significant method for differentiating benign from malignant lesions, evaluating treatment response, and defining angiogenesis [64][65][66].…”

Section: Computed Tomographymentioning

confidence: 99%

“…The lesion show (arrow) hyperintense signal in T2-W sequence (A), hyperehancement during arterial phase (B), wash out appearance (C) during portal phase and nodule in nodule appearance in hepatobiliary phase (D) imaging technique. However, because of the increased radiation dose, CT perfusion of liver is largely unfulfilled clinically [64].…”

Section: Computed Tomographymentioning

confidence: 99%

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Diagnostic evaluation and ablation treatments assessment in hepatocellular carcinoma

Granata

Grassi

Fusco³

et al. 2021

Infect Agents Cancer

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This article provides an overview of diagnostic evaluation and ablation treatment assessment in Hepatocellular Carcinoma (HCC). Only studies, in the English language from January 2010 to January 202, evaluating the diagnostic tools and assessment of ablative therapies in HCC patients were included. We found 173 clinical studies that satisfied the inclusion criteria.HCC may be noninvasively diagnosed by imaging findings. Multiphase contrast-enhanced imaging is necessary to assess HCC. Intravenous extracellular contrast agents are used for CT, while the agents used for MRI may be extracellular or hepatobiliary. Both gadoxetate disodium and gadobenate dimeglumine may be used in hepatobiliary phase imaging. For treatment-naive patients undergoing CT, unenhanced imaging is optional; however, it is required in the post treatment setting for CT and all MRI studies. Late arterial phase is strongly preferred over early arterial phase. The choice of modality (CT, US/CEUS or MRI) and MRI contrast agent (extracelllar or hepatobiliary) depends on patient, institutional, and regional factors. MRI allows to link morfological and functional data in the HCC evaluation. Also, Radiomics is an emerging field in the assessment of HCC patients.Postablation imaging is necessary to assess the treatment results, to monitor evolution of the ablated tissue over time, and to evaluate for complications. Post- thermal treatments, imaging should be performed at regularly scheduled intervals to assess treatment response and to evaluate for new lesions and potential complications.

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“…Accurate diagnosis and staging of HCC can be achieved by CT ( Figure 3 ) or MRI ( Figure 4 ) in the absence of invasive methods, when precise and stringent criteria are applied [ 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 ]. Although MRI proves to be more sensitive in the characterization of liver lesions, particularly with hepatospecific contrast agents, there is no unambiguous indication from the pool of experts [ 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 ].…”

Section: Li-radsmentioning

confidence: 99%

A Narrative Review on LI-RADS Algorithm in Liver Tumors: Prospects and Pitfalls

et al. 2022

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Liver cancer is the sixth most detected tumor and the third leading cause of tumor death worldwide. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with specific risk factors and a targeted population. Imaging plays a major role in the management of HCC from screening to post-therapy follow-up. In order to optimize the diagnostic-therapeutic management and using a universal report, which allows more effective communication among the multidisciplinary team, several classification systems have been proposed over time, and LI-RADS is the most utilized. Currently, LI-RADS comprises four algorithms addressing screening and surveillance, diagnosis on computed tomography (CT)/magnetic resonance imaging (MRI), diagnosis on contrast-enhanced ultrasound (CEUS) and treatment response on CT/MRI. The algorithm allows guiding the radiologist through a stepwise process of assigning a category to a liver observation, recognizing both major and ancillary features. This process allows for characterizing liver lesions and assessing treatment. In this review, we highlighted both major and ancillary features that could define HCC. The distinctive dynamic vascular pattern of arterial hyperenhancement followed by washout in the portal-venous phase is the key hallmark of HCC, with a specificity value close to 100%. However, the sensitivity value of these combined criteria is inadequate. Recent evidence has proven that liver-specific contrast could be an important tool not only in increasing sensitivity but also in diagnosis as a major criterion. Although LI-RADS emerges as an essential instrument to support the management of liver tumors, still many improvements are needed to overcome the current limitations. In particular, features that may clearly distinguish HCC from cholangiocarcinoma (CCA) and combined HCC-CCA lesions and the assessment after locoregional radiation-based therapy are still fields of research.

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Tumor attenuation and quantitative analysis of perfusion parameters derived from tri-phasic CT scans in hepatocellular carcinoma

Cited by 3 publications

References 32 publications

Conventional, functional and radiomics assessment for intrahepatic cholangiocarcinoma

Conventional, functional and radiomics assessment for intrahepatic cholangiocarcinoma

Diagnostic evaluation and ablation treatments assessment in hepatocellular carcinoma

A Narrative Review on LI-RADS Algorithm in Liver Tumors: Prospects and Pitfalls

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