Tumor budding in invasive breast cancer - An indispensable budding touchstone

Kumarguru, BN; Ramaswamy, Anikode Subramanian; Shaik, Shahanuma; Karri, Aruna; Srinivas, V; Prashant, BM

doi:10.4103/ijpm.ijpm_731_18

Cited by 13 publications

(15 citation statements)

References 9 publications

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“…More investigation proved that, as the other studies revealed, 13 , 18 - 22 there was a reverse relationship between tumor stage, grade, and size, the number of lymph nodes involved, and the presence of metastasis, with the 5-year survival rates of the patients, so that as the stage or grade or size of the tumor or the number of lymph nodes involved increases, the five-year survival rate of the patients decreased. Our study also stated that an increase in the number of intratumoral or peritumoral buds could be associated with a decrease in the five-year survival rates of the patients.…”

Section: Discussionmentioning

confidence: 65%

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The Relationship Between Tumor Budding and Patient’s Survival in Breast Cancer

Ranaee,

Torabi,

Azhganzad

et al. 2024

Clin Med�Insights�Pathol

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Introduction: Breast cancer is a severe life-threatening condition in which many women are involved yearly. One factor that has recently been noticed and investigated as a diagnostic predictor of this type of cancer is the number of tumor buds and the relation of this factor with a patient’s survival rate. Materials and methods: This study includes 150 female patients over 18 years old with a mean age of 53.99 ± 12.56 years old with breast cancer, which was diagnosed at various medical centers, including Rouhani Hospital itself, and referred to Rouhani Hospital Medical Center, Babol, Iran. The number of intratumoral and peritumoral buds in patients’ microscopic slides were archived and evaluated along with tumor microenvironment on hematoxylin and eosin (H&E) slides and compared to other clinicopathological findings. This article precisely investigated the relationship between the number of intratumoral and peritumoral buds with patients’ 5-year survival rate. Also, the relationship between age, tumor stage, grade, size, the number of lymph nodes involved, and the presence of metastasis with the number of intratumoral and peritumoral buds was studied. Results and discussion: The result showed a significant statistical association between the number of intratumoral and peritumoral buds with tumor size, tumor stage, presence of metastasis, the number of lymph nodes involved, and 5-year survival rate. On the other hand, there is not a significant statistical association between the number of intratumoral and peritumoral buds with age and tumor grade. Conclusion: Our investigation revealed a significant statistical relationship between the number of tumor buds and patients’ survival rate. So, this factor should be considered significant to help those patients increase their survival ratio.

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Section: Discussionmentioning

confidence: 65%

“…In a study by Kumarguru et al, 18 50 patients were studied, and the result, considering 20 tumor buds as cut-off, point revealed a significant direct relationship between the number of tumor buds and metastasis to lymph vessels and nodes.…”

Section: Discussionmentioning

confidence: 98%

The Relationship Between Tumor Budding and Patient’s Survival in Breast Cancer

Ranaee,

Torabi,

Azhganzad

et al. 2024

Clin Med�Insights�Pathol

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“…2021 ). In a recent study, Mönckeberg MS was associated with the presence of tumor budding, an adverse prognostic factor in invasive breast cancer ( Kumarguru et al . 2020 ).…”

Section: Discussionmentioning

confidence: 98%

Mönckeberg sclerosis in patients with thyroid papillary carcinoma

Venetsanaki,

Zisimopoulou,

Zouli

et al. 2024

Endocrine Oncology

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Background: Mönckeberg sclerosis is a form of calcification of the tunica media of small and medium size arteries. It occurs more often in the peripheral arteries of the lower limbs and it has been associated with diabetes and renal disease. Although there are a few reports of Mönckeberg sclerosis in thyroid vessels, there are no data regarding its significance in thyroid disease. Objective: To investigate the possible prognostic value of Mönckeberg sclerosis in thyroid vessels of patients with diagnosed thyroid cancer. Methods: We retrospectively studied patients with papillary thyroid cancer treated at the Theagenio Hospital of Thessaloniki from 2005 to 2021. The patients were divided in two groups based on the presence, or not, of histopathological findings of Mönckeberg sclerosis in the thyroid vessels-along with papillary thyroid cancer. Patient characteristics, histopathological details, personal history of thyroid disease and metabolic parameters were compared between the two groups. Results: Thirty-three patients with papillary thyroid carcinoma and Mönckeberg sclerosis were identified and matched to thirty-three controls with papillary thyroid cancer, without evidence of Mönckeberg sclerosis. The metabolic profile of patients with Mönckeberg sclerosis was not significantly different from those who did not have Mönckeberg sclerosis. Moreover, the comparison between the two groups did not reveal any remarkable differences in terms of the aggressiveness of the disease. Conclusions: The presence of Mönckeberg sclerosis does not seem to impact on histological characteristics of patients with papillary thyroid cancer.

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“…El hiperparatiroidismo primario (HPP) ocurre como resultado de adenomas (80 %-85 %), hiperplasias (10 %-15 %) o carcinoma (1 %) de las glándulas paratiroides Haz clic o pulse aquí para escribir texto [4,6]. Su incidencia varía según la geografía y los métodos diagnósticos, ya que en población general se estima de 10/100.000 año Haz clic o pulse aquí para escribir texto [6,7]; además, en la mayoría de casos se desconoce su etiología, sin embargo, se han identificado diferentes factores de riesgo como las radiaciones ionizantes en infancia, el uso crónico de litio, dos principales mutaciones genéticas implicadas en el ciclo celular contribuyentes de HPP, el CCND1 (que codifica la ciclina D1) presente hasta en el 40 % de los casos de adenomas esporádicos y el MEN1 (que codifica la menina) hasta en un 35 % de los casos Haz clic o pulse aquí para escribir texto [7,8].…”

Section: Tabla 2 Causas De Hipercalcemiaunclassified

“…Las manifestaciones renales van a estar dadas por la nefrolitiasis hasta en el 20 % de los pacientes, la hipercalciuria en el 40 %, además de disminución de la tasa de filtración glomerular, nefrocalcinosis y trastornos tubulares. Dentro de las manifestaciones óseas se encontró una disminución de la densidad ósea, osteoporosis hasta en un 50 % de los casos acompañada de fracturas patológicas, reabsorción de los extremos distales de las clavículas, osteítis fibrosa quística, erosiones subperiósticas en los bordes radiales de las falanges media o terminal, "cráneo de pimienta" y tumores pardos, presentándose múltiples lesiones líticas en las estructuras óseas visualizadas que correspondían a tumores pardos en nuestra paciente y visibles en el TAC abdominopélvico con contrasteHaz clic o pulse aquí para escribir texto [4,6]. Los dolores óseo, articular y muscular son frecuentes cuando el estado hiperparatiroideo es prolongado y severo.…”

Section: Tabla 2 Causas De Hipercalcemiaunclassified

Hipercalcemia asociada a hiperparatiroidismo primario: enfoque y manejo a partir de un caso clínico

Serrano

Sanmartin

Reina

et al. 2023

Rev. Colomb. Nefrol.

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Introducción: el calcio es el electrolito más abundante del cuerpo humano y la hipercalcemia es el trastorno común causado normalmente por el hiperparatiroidismo primario o malignidad, su manejo depende de la presentación y causa subyacente. Además, una proporción de casos se presentan como una emergencia, lo que conlleva a una mortalidad significativa. Objetivo: mostrar un caso inusual de presentación clínica de hipercalcemia asociada a hiperparatiroidismo primario y, asimismo, dar una breve revisión acerca del enfoque y el manejo de esta patología. Presentación del caso: paciente femenina de 32 años, antecedente de adenoma paratiroideo no resecado y pancreatitis, asiste por tres días de dolor abdominal de tipo cólico y de moderada intensidad, acompañado de episodios eméticos de contenido alimentario, paraclínicos iniciales con hipercalcemia severa, electrocardiograma con bloqueo auriculoventricular grado I, gases arteriales con alcalosis respiratoria aguda e hiperlactatemia. También se le practicó un TAC de abdomen donde este apareció con tumores pardos. Se ingreso? a la UCI para la administración de líquidos endovenosos, diuréticos de asa y cinacalcet, pero no presentó mejoría, por lo que se indicó terapia de hemodiálisis. Discusión y conclusión: la hipercalcemia es un hallazgo frecuente. El hiperparatiroidismo primario y la neoplasia maligna son las dos causas más frecuentes de aumento de los niveles de calcio sérico y, en conjunto, representan alrededor del 90?% de todos los casos, donde los valores en suero varían entre el calcio total (8,5 y 10,5 mg/dl) y el iónico (1,16-1,31). La concentración sérica de Ca 2+ esta? estrechamente relacionada por las acciones de la hormona paratiroidea y el calcitriol, donde el hiperparatiroidismo primario ocurre como resultado de adenomas, hiperplasias y carcinoma. Las manifestaciones clínicas y la severidad van a estar correlacionadas con el tiempo de duración de la enfermedad, los niveles de calcio y de PTH. Dentro del tratamiento, este será guiado por su causa, sin embargo, es posible clasificarlo en tratamiento urgente y no urgente. Además, el enfoque de la hipercalcemia aguda severa es un reto diagnóstico dadas las múltiples causas que pueden llevar a este trastorno hidroelectrolítico y la rápida instauración de tratamiento que se requiere cuando es detectada.

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Tumor budding in invasive breast cancer - An indispensable budding touchstone

Cited by 13 publications

References 9 publications

The Relationship Between Tumor Budding and Patient’s Survival in Breast Cancer

The Relationship Between Tumor Budding and Patient’s Survival in Breast Cancer

Mönckeberg sclerosis in patients with thyroid papillary carcinoma

Hipercalcemia asociada a hiperparatiroidismo primario: enfoque y manejo a partir de un caso clínico

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