2024
DOI: 10.1002/exp.20230171
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Tumor cell membrane‐based vaccines: A potential boost for cancer immunotherapy

Muyang Yang,
Jie Zhou,
Liseng Lu
et al.

Abstract: Because therapeutic cancer vaccines can, in theory, eliminate tumor cells specifically with relatively low toxicity, they have long been considered for application in repressing cancer progression. Traditional cancer vaccines containing a single or a few discrete tumor epitopes have failed in the clinic, possibly due to challenges in epitope selection, target downregulation, cancer cell heterogeneity, tumor microenvironment immunosuppression, or a lack of vaccine immunogenicity. Whole cancer cell or cancer mem… Show more

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Cited by 5 publications
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“…Membranes from different cell types are extracted to encapsulate cargos, and some of the biological functions of the original cells may be retained due to the good preservation of cell membrane structures. Tumor cell membranes are also employed in the fabrication of cancer vaccines, as both the source of tumor-specific epitopes and delivery vehicles [ 108 ]. Also following this strategy, membranes of mature DCs have been extracted in a recent study to encapsulate mRNA and achieve improved accumulation in lymphoid organs [ 109 ].…”
Section: Bio-modifications For Ln-targetingmentioning
confidence: 99%
“…Membranes from different cell types are extracted to encapsulate cargos, and some of the biological functions of the original cells may be retained due to the good preservation of cell membrane structures. Tumor cell membranes are also employed in the fabrication of cancer vaccines, as both the source of tumor-specific epitopes and delivery vehicles [ 108 ]. Also following this strategy, membranes of mature DCs have been extracted in a recent study to encapsulate mRNA and achieve improved accumulation in lymphoid organs [ 109 ].…”
Section: Bio-modifications For Ln-targetingmentioning
confidence: 99%