Tumor Derived Extracellular Vesicles Modulate Gene Expression in T cells

Pando, Alejandro; Schorl, Christoph; Fast, Loren D.; Reagan, John L.

doi:10.1016/j.gene.2022.146920

Cited by 7 publications

(1 citation statement)

References 89 publications

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“…Elevated levels of Treg cells in peripheral blood are associated with poor outcomes in patients with AML (56). Pando et al investigated the effects of AML-derived EVs on T cell subsets by an in vitro approach to study the effects of EVs derived from the human AML cell line MOLM-14 cells on CD4 + , CD4 + CD39 + , and CD8 + T cell subsets from healthy individuals; the results showed that tumor-derived EVs modulate T cell responses by upregulating immune processes, such as immunosuppression and oncogenic gene expression (57).…”

Section: Aml-derived Exosomes Cause the Dysfunction Of Immune Cells E...mentioning

confidence: 99%

Utilizing exosomes as sparking clinical biomarkers and therapeutic response in acute myeloid leukemia

Wang,

Wu,

Zheng

et al. 2024

Front. Immunol.

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Acute myeloid leukemia (AML) is a malignant clonal tumor originating from immature myeloid hematopoietic cells in the bone marrow with rapid progression and poor prognosis. Therefore, an in-depth exploration of the pathogenesis of AML can provide new ideas for the treatment of AML. In recent years, it has been found that exosomes play an important role in the pathogenesis of AML. Exosomes are membrane-bound extracellular vesicles (EVs) that transfer signaling molecules and have attracted a large amount of attention, which are key mediators of intercellular communication. Extracellular vesicles not only affect AML cells and normal hematopoietic cells but also have an impact on the bone marrow microenvironment and immune escape, thereby promoting the progression of AML and leading to refractory relapse. It is worth noting that exosomes and the various molecules they contain are expected to become the new markers for disease monitoring and prognosis of AML, and may also function as drug carriers and vaccines to enhance the treatment of leukemia. In this review, we mainly summarize to reveal the role of exosomes in AML pathogenesis, which helps us elucidate the application of exosomes in AML diagnosis and treatment.

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Section: Aml-derived Exosomes Cause the Dysfunction Of Immune Cells E...mentioning

confidence: 99%

Utilizing exosomes as sparking clinical biomarkers and therapeutic response in acute myeloid leukemia

Wang,

Wu,

Zheng

et al. 2024

Front. Immunol.

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Exosomes derived from EphB2-overexpressing bone marrow mesenchymal stem cells regulate immune balance and repair barrier function

et al. 2023

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BackgroundDisruption of intestinal barrier function and an imbalance in intestinal immunity are crucial for the occurrence and development of ulcerative colitis. Because of their important roles in regulating in ammation and immunity, exosomes (Exos) released from bone marrow mesenchymal stem cells (BMSCs) may be useful for treating ulcerative colitis. The EphB/EphrinB signaling pathway plays a crucial role in the in ammatory process and the development and function of immune cells, and can mediate long-distance intercellular communication through extracellular vesicles. This study was conducted to explore the effects of pre-modi ed BMSC-Exos expressing EphB2 (EphB2-Exos) on immunoregulation in vitro. MethodsWe transfected a lentivirus vector encoding EphB2 into BMSCs and isolated EphB2-Exos from the culture supernatant. In ammation and oxidative damage in the human colon adenocarcinoma cell line (Caco-2) were induced by dextran sulfate sodium/hydrogen peroxide. In addition, spleen CD4 + T lymphocytes of rats were sorted in vitro. We conducted a series of experiments to explore the biological functions of EphB2-Exos. ResultsEphB2-Exos were successfully isolated and were found to signi cantly protect the activity, proliferation, and migration of Caco-2 cells that were inhibited by dextran sulfate sodium. EphB2-Exos alleviated in ammation and apoptosis and increased the activity of antioxidant enzymes while inhibiting oxidative stress in Caco-2 cells. EphB2-Exos restored barrier function by inhibiting the RhoA/ROCK pathway and regulated the polarization of CD4 + T cells. ConclusionEphB2-Exos enhanced intestinal barrier function and regulated the immune balance by inhibiting the RhoA/ROCK pathway in vitro. These ndings suggest that EphB2-Exos can be applied as a cell-free therapy for ulcerative colitis.

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Drug delivery methods for cancer immunotherapy

Pérez-Herrero

Lanier

Krishnan

et al. 2023

Drug Deliv. and Transl. Res.

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Despite the fact that numerous immunotherapy-based drugs have been approved by the FDA for the treatment of primary and metastatic tumors, only a small proportion of the population can benefit from them because of primary and acquired resistances. Moreover, the translation of immunotherapy from the bench to the clinical practice is being challenging because of the short half-lives of the involved molecules, the difficulties to accomplish their delivery to the target sites, and some serious adverse effects that are being associated with these approaches. The emergence of drug delivery vehicles in the field of immunotherapy is helping to overcome these difficulties and limitations and this review describes how, providing some illustrative examples. Moreover, this article provides an exhaustive review of the studies that have been published to date on the particular case of hematological cancers. Graphical Abstract (Created with BioRender)

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Tumor Derived Extracellular Vesicles Modulate Gene Expression in T cells

Cited by 7 publications

References 89 publications

Utilizing exosomes as sparking clinical biomarkers and therapeutic response in acute myeloid leukemia

Utilizing exosomes as sparking clinical biomarkers and therapeutic response in acute myeloid leukemia

Exosomes derived from EphB2-overexpressing bone marrow mesenchymal stem cells regulate immune balance and repair barrier function

Drug delivery methods for cancer immunotherapy

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