Tumor-Derived Membrane Vesicles Restrain Migration in Gliomas By Altering Collective Polarization
Megha Jhunjhunwala,
Lin-Sheng Yu,
Ping-Chen Kuo
et al.
Abstract:Mechanobiology is a cornerstone in physiology. However, its role in biomedical applications remains considerably undermined. In this study, we employed cell membrane vesicles (CMVs), which are currently being used as nanodrug carriers, as tactile cues for mechano-regulation of collective cell behaviors. Gliomas, which are among the most resilient brain tumors and have a low patient survival rate, were used as the cell model. We observed that mechanical responses due to the application of glioma-or microglia-de… Show more
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